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Human IL‐6, IL‐17, IL‐1β, and TNF‐α differently regulate the expression of pro‐inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells

Human IL‐6, IL‐17, IL‐1β, and TNF‐α differently regulate the expression of pro‐inflammatory... AbbreviationsHUVECshuman umbilical vein endothelial cellsMAPKsmitogen‐activated protein kinasesNF‐κBnuclear factor kappa BPAECsporcine aortic endothelial cellsrhIL‐6recombinant human IL‐6rpIL‐6recombinant porcine IL‐6SLA‐Iswine leukocyte antigen class ISTATsignal transducer and activator of transcriptionIntroductionOrgan transplantation is an effective therapy for end‐stage organ failure, but a major limitation is the shortage of deceased human organs. For physiological, anatomical, economic, and ethical reasons, pigs are considered to be the most suitable animals to solve this problem. However, immune rejection is a major hurdle for xenotransplantation. Pro‐inflammatory cytokines are essential factors in the cellular immune response, and we predict that some pro‐inflammatory cytokines play an important pathological role in xenotransplantation. However, the roles of these cytokines in xenotransplantation remain unknown or uncertain.Endothelial cells (ECs) have various functions in regulating inflammatory response, coagulation, and cell survival or death. EC dysfunction has been related to various diseases, such as tumor metastasis, atherosclerosis, and persistent chronic inflammation. ECs are the first and most important line of defense because they are the first cells to be recognized by immune cells. They are the critical cells in the inflammatory and coagulation responses in xenotransplantation. ECs play a central role in allograft and xenograft injury. They are the relevant cells for xenotransplantation research.Various pro‐inflammatory cytokines are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Human IL‐6, IL‐17, IL‐1β, and TNF‐α differently regulate the expression of pro‐inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells

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References (47)

Publisher
Wiley
Copyright
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12291
pmid
28303603
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsHUVECshuman umbilical vein endothelial cellsMAPKsmitogen‐activated protein kinasesNF‐κBnuclear factor kappa BPAECsporcine aortic endothelial cellsrhIL‐6recombinant human IL‐6rpIL‐6recombinant porcine IL‐6SLA‐Iswine leukocyte antigen class ISTATsignal transducer and activator of transcriptionIntroductionOrgan transplantation is an effective therapy for end‐stage organ failure, but a major limitation is the shortage of deceased human organs. For physiological, anatomical, economic, and ethical reasons, pigs are considered to be the most suitable animals to solve this problem. However, immune rejection is a major hurdle for xenotransplantation. Pro‐inflammatory cytokines are essential factors in the cellular immune response, and we predict that some pro‐inflammatory cytokines play an important pathological role in xenotransplantation. However, the roles of these cytokines in xenotransplantation remain unknown or uncertain.Endothelial cells (ECs) have various functions in regulating inflammatory response, coagulation, and cell survival or death. EC dysfunction has been related to various diseases, such as tumor metastasis, atherosclerosis, and persistent chronic inflammation. ECs are the first and most important line of defense because they are the first cells to be recognized by immune cells. They are the critical cells in the inflammatory and coagulation responses in xenotransplantation. ECs play a central role in allograft and xenograft injury. They are the relevant cells for xenotransplantation research.Various pro‐inflammatory cytokines are

Journal

Xenotransplantation – Wiley

Published: Mar 1, 2017

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