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Xenotransplantation 2016: 23: 370–380 © 2016 John Wiley & Sons A/S. doi: 10.1111/xen.12254 Published by John Wiley & Sons Ltd. XENOTRANSPLANTATION Original Article Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration? 1 1 Lee W, Long C, Ramsoondar J, Ayares D, Cooper DKC, Manji RA, Whayoung Lee, Cassandra Long, Hara H. Human antibody recognition of xenogeneic antigens (NeuGc Jagdeece Ramsoondar, David 2 1 and Gal) on porcine heart valves: could genetically modified pig heart Ayares, David K. C. Cooper, 3,4, valves reduce structural valve deterioration? Xenotransplantation 2016; Rizwan A. Manji * and 23: 370–380. © 2016 John Wiley & Sons A/S. Published by John Wiley 1, Hidetaka Hara * & Sons Ltd. Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, Revivicor, Abstract: Background: Glutaraldehyde-fixed bioprosthetic heart valves Blacksburg, VA, Department of Surgery, University (GBHVs) derived from wild-type (WT, genetically unmodified) pigs are 4 of Manitoba, Winnipeg, MB, Cardiac Sciences widely used clinically for heart valve replacement. There is evidence that Program, Winnipeg Regional Health Authority and their failure is related to an immune response. The use of valves from St Boniface Hospital,
Xenotransplantation – Wiley
Published: Sep 1, 2016
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