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Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration?

Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could... Xenotransplantation 2016: 23: 370–380 © 2016 John Wiley & Sons A/S. doi: 10.1111/xen.12254 Published by John Wiley & Sons Ltd. XENOTRANSPLANTATION Original Article Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration? 1 1 Lee W, Long C, Ramsoondar J, Ayares D, Cooper DKC, Manji RA, Whayoung Lee, Cassandra Long, Hara H. Human antibody recognition of xenogeneic antigens (NeuGc Jagdeece Ramsoondar, David 2 1 and Gal) on porcine heart valves: could genetically modified pig heart Ayares, David K. C. Cooper, 3,4, valves reduce structural valve deterioration? Xenotransplantation 2016; Rizwan A. Manji * and 23: 370–380. © 2016 John Wiley & Sons A/S. Published by John Wiley 1, Hidetaka Hara * & Sons Ltd. Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, Revivicor, Abstract: Background: Glutaraldehyde-fixed bioprosthetic heart valves Blacksburg, VA, Department of Surgery, University (GBHVs) derived from wild-type (WT, genetically unmodified) pigs are 4 of Manitoba, Winnipeg, MB, Cardiac Sciences widely used clinically for heart valve replacement. There is evidence that Program, Winnipeg Regional Health Authority and their failure is related to an immune response. The use of valves from St Boniface Hospital, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration?

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References (43)

Publisher
Wiley
Copyright
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12254
pmid
27511593
Publisher site
See Article on Publisher Site

Abstract

Xenotransplantation 2016: 23: 370–380 © 2016 John Wiley & Sons A/S. doi: 10.1111/xen.12254 Published by John Wiley & Sons Ltd. XENOTRANSPLANTATION Original Article Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration? 1 1 Lee W, Long C, Ramsoondar J, Ayares D, Cooper DKC, Manji RA, Whayoung Lee, Cassandra Long, Hara H. Human antibody recognition of xenogeneic antigens (NeuGc Jagdeece Ramsoondar, David 2 1 and Gal) on porcine heart valves: could genetically modified pig heart Ayares, David K. C. Cooper, 3,4, valves reduce structural valve deterioration? Xenotransplantation 2016; Rizwan A. Manji * and 23: 370–380. © 2016 John Wiley & Sons A/S. Published by John Wiley 1, Hidetaka Hara * & Sons Ltd. Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, Revivicor, Abstract: Background: Glutaraldehyde-fixed bioprosthetic heart valves Blacksburg, VA, Department of Surgery, University (GBHVs) derived from wild-type (WT, genetically unmodified) pigs are 4 of Manitoba, Winnipeg, MB, Cardiac Sciences widely used clinically for heart valve replacement. There is evidence that Program, Winnipeg Regional Health Authority and their failure is related to an immune response. The use of valves from St Boniface Hospital,

Journal

Xenotransplantation – Wiley

Published: Sep 1, 2016

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