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Human alcohol dehydrogenase ADH 1 , ADH 2 and ADH 3 loci in a mixed population of Bahia, Brazil

Human alcohol dehydrogenase ADH 1 , ADH 2 and ADH 3 loci in a mixed population of Bahia, Brazil Summary 1. The three structural gene loci of human alcohol dehydrogenase have been studied in liver, jejunum and lung from 300 newborns in a triracially mixed population of Bahia, Brazil. 2. The frequency of the ADH23 allele was 0,1392, suggesting that the ADH23 allele is less frequent in Negroes. 3. A new ADE2 variant was identified. The electrophoretic pattern was interpreted as due to a new allele which is provisionally called ADH2Bahfa. 4. By electrophoretic classification the ‘atypical’ variant was found in 2.8% of the sample. A question is raised regarding the ancestral origin of the ‘atypical’ variant in the population. Because this variant is common in Japanese it may have reached the present day population of Bahia through their American Indian ancestors. 5. Subjective estimation of the proportions of β chains by giving scores to the liver isozymes αα, αβ and βß showed a clear relationship between the fetal weight and the β chain activity. 6. The proportion of β chains in the liver is significantly less when there is no enzyme activity in the lung, indicating some synchronous ‘turning on’ mechanism for alcohol dehydrogenase synthesis in both tissues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Human alcohol dehydrogenase ADH 1 , ADH 2 and ADH 3 loci in a mixed population of Bahia, Brazil

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References (15)

Publisher
Wiley
Copyright
Copyright © 1976 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1976.tb00136.x
Publisher site
See Article on Publisher Site

Abstract

Summary 1. The three structural gene loci of human alcohol dehydrogenase have been studied in liver, jejunum and lung from 300 newborns in a triracially mixed population of Bahia, Brazil. 2. The frequency of the ADH23 allele was 0,1392, suggesting that the ADH23 allele is less frequent in Negroes. 3. A new ADE2 variant was identified. The electrophoretic pattern was interpreted as due to a new allele which is provisionally called ADH2Bahfa. 4. By electrophoretic classification the ‘atypical’ variant was found in 2.8% of the sample. A question is raised regarding the ancestral origin of the ‘atypical’ variant in the population. Because this variant is common in Japanese it may have reached the present day population of Bahia through their American Indian ancestors. 5. Subjective estimation of the proportions of β chains by giving scores to the liver isozymes αα, αβ and βß showed a clear relationship between the fetal weight and the β chain activity. 6. The proportion of β chains in the liver is significantly less when there is no enzyme activity in the lung, indicating some synchronous ‘turning on’ mechanism for alcohol dehydrogenase synthesis in both tissues.

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 1976

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