Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Egorov, Bassam Hamam, E. Fransén, M. Hasselmo, A. Alonso (2002)
Graded persistent activity in entorhinal cortex neuronsNature, 420
W. Lin, A. Çelik, R. Paczynski (1999)
Regional cerebral blood volume: A comparison of the dynamic imaging and the steady state methodsJournal of Magnetic Resonance Imaging, 9
William Wu, A. Brickman, J. Luchsinger, P. Ferrazzano, P. Pichiule, M. Yoshita, T. Brown, C. DeCarli, C. Barnes, R. Mayeux, S. Vannucci, S. Small (2008)
The brain in the age of old: The hippocampal formation is targeted differentially by diseases of late lifeAnnals of Neurology, 64
C. Kawas, M. Corrada, R. Brookmeyer, A. Morrison, S. Resnick, A. Zonderman, D. Arenberg (2003)
Visual memory predicts Alzheimer’s disease more than a decade before diagnosisNeurology, 60
J. Pittman, H. Andrews, T. Tatemichi, Bruce Link, E. Struening, Y. Stern, R. Mayeux (1992)
Diagnosis of dementia in a heterogeneous population. A comparison of paradigm-based diagnosis and physician's diagnosis.Archives of neurology, 49 5
Schacter (1992)
Implicit and explicit memory for novel visual objects in older and younger adultsPsychol Aging, 7
H. Moreno, William Wu, Thomas Lee, A. Brickman, R. Mayeux, T. Brown, S. Small (2007)
Imaging the Aβ-Related Neurotoxicity of Alzheimer DiseaseJAMA Neurology, 64
Small (2004)
From the cover: Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to agingProc Natl Acad Sci USA, 101
L. Squire, C. Stark, R. Clark (2004)
The medial temporal lobe.Annual review of neuroscience, 27
J. Mandeville, J. Marota, B. Kosofsky, J. Keltner, R. Weissleder, B. Rosen, R. Weisskoff (1998)
Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulationMagnetic Resonance in Medicine, 39
M. Albert (1996)
Cognitive and neurobiologic markers of early Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America, 93 24
J. Leutgeb, S. Leutgeb, M. Moser, E. Moser (2007)
Pattern Separation in the Dentate Gyrus and CA3 of the HippocampusScience, 315
J. Belliveau, D. Kennedy, R. McKinstry, B. Buchbinder, R. Weisskoff, M. Cohen, J. Vevea, T. Brady, B. Rosen (1991)
Functional mapping of the human visual cortex by magnetic resonance imaging.Science, 254 5032
K. Nakazawa, M. Quirk, R. Chitwood, Masahiko Watanabe, M. Yeckel, L. Sun, Akira Kato, C. Carr, D. Johnston, M. Wilson, S. Tonegawa (2002)
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory RecallScience, 297
Adam Gazzaley, Steven Siegel, J. Kordower, E. Mufson, John Morrison (1996)
Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys.Proceedings of the National Academy of Sciences of the United States of America, 93 7
W. Suzuki, E. Miller, R. Desimone (1997)
Object and place memory in the macaque entorhinal cortex.Journal of neurophysiology, 78 2
E. Fransén, A. Alonso, C. Dickson, J. Magistretti, Michael Hasselmo (2004)
Ionic mechanisms in the generation of subthreshold oscillations and action potential clustering in entorhinal layer II stellate neuronsHippocampus, 14
A. Brickman, N. Schupf, J. Manly, J. Luchsinger, H. Andrews, M. Tang, C. Reitz, J. Muraskin, Amir Zahra, S. Small, R. Mayeux, C. DeCarli, T. Brown (2008)
P4-011: Brain morphology in elderly African-Americans, Caribbean Hispanics, and Caucasians from Northern ManhattanAlzheimer's & Dementia, 4
Q. Shen, H. Ren, T. Duong (2008)
CBF, BOLD, CBV, and CMRO2 fMRI signal temporal dynamics at 500‐msec resolutionJournal of Magnetic Resonance Imaging, 27
S. Small (2001)
Age-related memory decline: current concepts and future directions.Archives of neurology, 58 3
S. Small, G. Perera, R. DeLaPaz, R. Mayeux, Y. Stern (1999)
Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's diseaseAnnals of Neurology, 45
K. Schon, M. Hasselmo, M. LoPresti, Marisa Tricarico, C. Stern (2004)
Persistence of Parahippocampal Representation in the Absence of Stimulus Input Enhances Long-Term Encoding: A Functional Magnetic Resonance Imaging Study of Subsequent Memory after a Delayed Match-to-Sample TaskThe Journal of Neuroscience, 24
Y. Stern, Howard Andrews, John Pittman, Mary Sano, T. Tatemichi, R. Lantigua, R. Mayeux (1992)
Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education.Archives of neurology, 49 5
H. Moreno, William Wu, Thomas Lee, A. Brickman, R. Mayeux, T. Brown, S. Small (2007)
Imaging the Abeta-related neurotoxicity of Alzheimer disease.Archives of neurology, 64 10
Walter Sturm (2007)
Neuropsychological assessmentJournal of Neurology, 254
M. Yassa, Shauna Stark, A. Bakker, M. Albert, M. Gallagher, C. Stark (2010)
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive ImpairmentNeuroImage, 51
R. Gonzalez, Alan Fischman, Alexander Guimaraes, C. Carr, Chantal Stern, E. Halpern, J. Growdon, Bruce Rosen (1995)
Functional MR in the evaluation of dementia: correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18.AJNR. American journal of neuroradiology, 16 9
J. Mandeville, B. Jenkins, B. Kosofsky, M. Moskowitz, B. Rosen, J. Marota (2001)
Regional sensitivity and coupling of BOLD and CBV changes during stimulation of rat brainMagnetic Resonance in Medicine, 45
J. Manly, M. Tang, N. Schupf, Y. Stern, J. Vonsattel, R. Mayeux (2008)
Frequency and course of mild cognitive impairment in a multiethnic communityAnnals of Neurology, 63
C. Grady, A. McIntosh, B. Horwitz, J. Maisog, Leslie Ungerleider, M. Mentis, P. Pietrini, M. Schapiro, J. Haxby (1995)
Age-related reductions in human recognition memory due to impaired encoding.Science, 269 5221
H. Buschke, P. Fuld (1974)
Evaluating storage, retention, and retrieval in disordered memory and learningNeurology, 24
Motoharu Yoshida, E. Fransén, Michael Hasselmo (2008)
mGluR‐dependent persistent firing in entorhinal cortex layer III neuronsEuropean Journal of Neuroscience, 28
T. McHugh, Matthew Jones, J. Quinn, N. Balthasar, R. Coppari, J. Elmquist, B. Lowell, M. Fanselow, M. Wilson, S. Tonegawa (2007)
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal NetworkScience, 317
M. Albert (1997)
The ageing brain: normal and abnormal memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 352 1362
A. Brickman, N. Schupf, J. Manly, J. Luchsinger, H. Andrews, M. Tang, C. Reitz, S. Small, R. Mayeux, C. DeCarli, T. Brown (2008)
Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan.Archives of neurology, 65 8
Kelly Kent, Kenneth Hess, S. Tonegawa, S. Small (2007)
CA3 NMDA receptors are required for experience‐dependent shifts in hippocampal activityHippocampus, 17
L. Colgin, E. Moser, M. Moser (2008)
Understanding memory through hippocampal remappingTrends in Neurosciences, 31
B. Tahvildari, E. Fransén, A. Alonso, Michael Hasselmo (2007)
Switching between “On” and “Off” states of persistent activity in lateral entorhinal layer III neuronsHippocampus, 17
G. Fernández, J. Brewer, Zuo Zhao, G. Glover, J. Gabrieli (1999)
Level of sustained entorhinal activity at study correlates with subsequent cued‐recall performance: A functional magnetic resonance imaging study with high acquisition rateHippocampus, 9
Benton (1994)
Neuropsychological assessmentAnnu Rev Psychol, 45
V. Brun, S. Leutgeb, H. Wu, R. Schwarcz, M. Witter, E. Moser, M. Moser (2008)
Impaired Spatial Representation in CA1 after Lesion of Direct Input from Entorhinal CortexNeuron, 57
B. Young, T. Otto, G. Fox, H. Eichenbaum (1997)
Memory Representation within the Parahippocampal RegionThe Journal of Neuroscience, 17
M. West, P. Coleman, D. Flood, J. Troncoso (1994)
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's diseaseThe Lancet, 344
S. Resnick, K. Trotman, C. Kawas, A. Zonderman (1995)
Age-associated changes in specific errors on the Benton Visual Retention Test.The journals of gerontology. Series B, Psychological sciences and social sciences, 50 3
S. Schobel, Nicole Lewandowski, C. Corcoran, H. Moore, T. Brown, D. Malaspina, S. Small (2009)
Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders.Archives of general psychiatry, 66 9
M. Elias, A. Beiser, P. Wolf, R. Au, Roberta White, R. D’Agostino (2000)
The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort.Archives of neurology, 57 6
H. Braak, E. Braak (1996)
Evolution of the neuropathology of Alzheimer's diseaseActa Neurologica Scandinavica, 94
D. Schacter, L. Cooper, M. Valdiserri (1992)
Implicit and explicit memory for novel visual objects in older and younger adults.Psychology and aging, 7 2
Chelsea Toner, E. Pirogovsky, C. Kirwan, Paul Gilbert (2009)
Visual object pattern separation deficits in nondemented older adults.Learning & memory, 16 5
A. Bakker, C. Kirwan, Michael Miller, C. Stark, C. Stark (2008)
Pattern Separation in the Human Hippocampal CA3 and Dentate GyrusScience, 319
K. Schon, A. Atri, M. Hasselmo, Marisa Tricarico, M. LoPresti, C. Stern (2005)
Scopolamine Reduces Persistent Activity Related to Long-Term Encoding in the Parahippocampal Gyrus during Delayed Matching in HumansThe Journal of Neuroscience, 25
Recent studies suggest that individual hippocampal subregions perform distinct cognitive operations and are differentially targeted by aging and disease. Although originally developed to assess global hippocampal function, whether performance on standard memory tests used in neuropsychological batteries is associated with individual hippocampal subregions remains unknown. Here we addressed this issue by imaging 210 neuropsychologically characterized subjects using a high‐resolution variant of functional magnetic resonance imaging that generates maps reflective of basal hippocampal metabolism. Regression analysis revealed memory tests that differentially associate with two hippocampal subregions, the entorhinal cortex (EC) and the dentate gyrus (DG). Whereas performance on the delayed retention component of the Selective Reminding Test was associated with the EC, performance on the recognition component of the Benton Visual Retention Test (BVRT) was associated with the DG. Furthermore, elevation in blood glucose, previously shown to target the DG, was found to correlate selectively with the recognition component of the BVRT. These findings provide further evidence that the hippocampal subregions perform distinct roles, and, interpreted in the context of previous neuropsychological and imaging studies, confirm that aging and Alzheimer's disease target different hippocampal subregions. © 2010 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Sep 1, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.