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(2003)
Cell cycle length in young-adult and middle-aged rat dentate gyrus granule cell precursors
P. Rakic (2002)
Adult Neurogenesis in Mammals: An Identity CrisisThe Journal of Neuroscience, 22
M. Roy, R. Sapolsky (2003)
The Exacerbation of Hippocampal Excitotoxicity by Glucocorticoids Is Not Mediated by ApoptosisNeuroendocrinology, 77
T. Palmer, Andrew Willhoite, F. Gage (2000)
Vascular niche for adult hippocampal neurogenesisJournal of Comparative Neurology, 425
S. Avishai‐Eliner, C. Hatalski, E. Tabachnik, M. Eghbal‐Ahmadi, T. Baram (1999)
Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions.Brain research. Developmental brain research, 114 2
R. Sapolsky (1992)
Do glucocorticoid concentrations rise with age in the rat?Neurobiology of Aging, 13
C. Walker, K. Scribner, C. Cascio, M. Dallman (1991)
The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time-dependent and stressor-specific fashion.Endocrinology, 128 3
J. Rodríguez, M. Montaron, K. Petry, C. Aurousseau, M. Marinelli, S. Premier, G. Rougon, G. Rougon, M. Moal, D. Abrous (1998)
Complex regulation of the expression of the polysialylated form of the neuronal cell adhesion molecule by glucocorticoids in the rat hippocampusEuropean Journal of Neuroscience, 10
E. Gould, C. Woolley, H. Cameron, D. Daniels, B. McEwen (1991)
Adrenal steroids regulate postnatal development of the rat dentate gyrus: II. Effects of glucocorticoids and mineralocorticoids on cell birthJournal of Comparative Neurology, 313
H. Cameron, E. Gould (1994)
Adult neurogenesis is regulated by adrenal steroids in the dentate gyrusNeuroscience, 61
S. Yi, T. Baram (1994)
Corticotropin-releasing hormone mediates the response to cold stress in the neonatal rat without compensatory enhancement of the peptide's gene expression.Endocrinology, 135 6
H. Praag, A. Schinder, B. Christie, N. Toni, T. Palmer, F. Gage (2002)
Functional neurogenesis in the adult hippocampusNature, 415
J. Reul, E. Kloet (1985)
Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.Endocrinology, 117 6
B. Anlar, K. Sullivan, E. Feldman (1999)
Insulin-Like Growth Factor-I and Central Nervous System DevelopmentHormone and Metabolic Research, 31
Brian Kalman, R. Spencer (2002)
Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain.Endocrinology, 143 11
S. Akana, M. Dallman (1997)
Chronic cold in adrenalectomized, corticosterone (B)-treated rats: facilitated corticotropin responses to acute restraint emerge as B increases.Endocrinology, 138 8
T. Shors, G. Miesegaes, A. Beylin, Mingrui Zhao, Tracy Rydel, E. Gould (2001)
Neurogenesis in the adult is involved in the formation of trace memoriesNature, 410
H. Cameron, R. McKay (2001)
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrusJournal of Comparative Neurology, 435
Y. Jiao, Zhiqiang Sun, Teffy Lee, F. Fusco, T. Kimble, C. Meade, S. Cuthbertson, A. Reiner (1999)
A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sectionsJournal of Neuroscience Methods, 93
E. Kloet, P. Rosenfeld, J. Eekelen, Winardi Sutanto, Seymour Levine (1988)
Stress, glucocorticoids and development.Progress in brain research, 73
S Avishai‐Eliner, M Eghbal‐Ahmadi, E Tabachnik, KL Brunson, TZ Baram (2001)
Down‐regulation of hypothalamic corticotropin‐releasing hormone messenger ribonucleic acid (mRNA) precedes early‐life experience‐induced changes in hippocampal glucocorticoid receptor mRNA, 142
K. Fabel, H. Toda, Konstanze Fabel, T. Palmer (2003)
Copernican stem cells: Regulatory constellations in adult hippocampal neurogenesisJournal of Cellular Biochemistry, 88
R. Bender, J. Lauterborn, C. Gall, W. Cariaga, T. Baram (2001)
Enhanced CREB phosphorylation in immature dentate gyrus granule cells precedes neurotrophin expression and indicates a specific role of CREB in granule cell differentiationEuropean Journal of Neuroscience, 13
E. Gould, H. Cameron, D. Daniels, C. Woolley, B. McEwen (1992)
Adrenal hormones suppress cell division in the adult rat dentate gyrus, 12
M. Åberg, N. Åberg, Helena Hedbäcker, J. Oscarsson, P. Eriksson (2000)
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat HippocampusThe Journal of Neuroscience, 20
E. Gould, P. Tanapat (1999)
Stress and hippocampal neurogenesisBiological Psychiatry, 46
M. Eghbal‐Ahmadi, S. Avishai‐Eliner, C. Hatalski, T. Baram (1999)
Differential Regulation of the Expression of Corticotropin-Releasing Factor Receptor Type 2 (CRF2) in Hypothalamus and Amygdala of the Immature Rat by Sensory Input and Food IntakeThe Journal of Neuroscience, 19
N. Hayes, R. Nowakowski (2002)
Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice.Brain research. Developmental brain research, 134 1-2
Alice Schlessinger, W. Cowan, D. Gottlieb (1975)
An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the ratJournal of Comparative Neurology, 159
P. Ambrogini, Laura Orsini, Cecilia Mancini, P. Ferri, Icaro Barbanti, R. Cuppini (2002)
Persistently High Corticosterone Levels but Not Normal Circadian Fluctuations of the Hormone Affect Cell Proliferation in the Adult Rat Dentate GyrusNeuroendocrinology, 76
M. Dallman, S. Akana, C. Cascio, D. Darlington, L. Jacobson, N. Levin (1987)
Regulation of ACTH secretion: variations on a theme of B.Recent progress in hormone research, 43
G. Kempermann, D. Gast, G. Kronenberg, M. Yamaguchi, F. Gage (2003)
Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice, 130
E. Gould, P. Tanapat, B. McEwen, G. Flügge, E. Fuchs (1998)
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress.Proceedings of the National Academy of Sciences of the United States of America, 95 6
J. Bizon, M. Gallagher (2003)
Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive declineEuropean Journal of Neuroscience, 18
R. Sloviter, Anne Sollas, Evelyn Dean, S. Neubort (1993)
Adrenalectomy‐induced granule cell degeneration in the rat hippocampal dentate gyrus: Characterization of an in vivo model of controlled neuronal deathJournal of Comparative Neurology, 330
V. Heine, S. Maslam, M. Joëls, P. Lucassen (2004)
Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus–pituitary–adrenal axis activationNeurobiology of Aging, 25
T. Seki, Y. Arai (1995)
Age‐related production of new granule cells in the adult dentate gyrusNeuroReport, 6
C. Woolley, E. Gould, R. Sakai, R. Spencer, B. McEwen (1991)
Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult ratBrain Research, 554
M. Bohn (1980)
Granule cell genesis in the hippocampus of rats treated neonatally with hydrocortisoneNeuroscience, 5
S. Avishai‐Eliner, M. Eghbal‐Ahmadi, E. Tabachnik, K. Brunson, T. Baram (2001)
Down-Regulation of Hypothalamic Corticotropin-Releasing Hormone Messenger Ribonucleic Acid (mRNA) Precedes Early-Life Experience-Induced Changes in Hippocampal Glucocorticoid Receptor mRNA** This work was supported by NIH Grants NS-28912 and NS-39307.Endocrinology, 142 1
C. Walker, S. Akana, C. Cascio, M. Dallman (1990)
Adrenalectomy in the neonate: adult-like adrenocortical system responses to both removal and replacement of corticosterone.Endocrinology, 127 2
N. Nichols, M. Zięba, N. Bye (2001)
Do glucocorticoids contribute to brain aging?Brain Research Reviews, 37
Hornsby, Grootendorst, de ER (1996)
Dexamethasone Does Not Prevent Seven-Day ADX-Induced Apoptosis in the Dentate Gyrus of the Rat Hippocampus.Stress, 1 1
Elodie Drapeau, W. Mayo, C. Aurousseau, M. Moal, P. Piazza, D. Abrous (2003)
Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesisProceedings of the National Academy of Sciences of the United States of America, 100
Delia Zquez, Juan Pez, M. Morano, S. Kwak, S. Watson, H. Akil (1998)
α, β, and γ Mineralocorticoid Receptor Messenger Ribonucleic Acid Splice Variants: Differential Expression and Rapid Regulation in the Developing Hippocampus.Endocrinology, 139 7
A. Watts, S. Tanimura, G. Sanchez‐Watts (2004)
Corticotropin-releasing hormone and arginine vasopressin gene transcription in the hypothalamic paraventricular nucleus of unstressed rats: daily rhythms and their interactions with corticosterone.Endocrinology, 145 2
H. Cameron, C. Woolley, E. Gould (1993)
Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrusBrain Research, 611
P. Eriksson, E. Perfilieva, T. Björk-Eriksson, Ann-Marie Alborn, C. Nordborg, D. Peterson, F. Gage (1998)
Neurogenesis in the adult human hippocampusNature Medicine, 4
J. Herman, P. Patel, H. Akil, S. Watson (1989)
Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat.Molecular endocrinology, 3 11
K. Brunson, Najeeb Khan, M. Eghbal‐Ahmadi, T. Baram (2001)
Corticotropin (ACTH) acts directly on amygdala neurons to down‐regulate corticotropin‐releasing hormone gene expressionAnnals of Neurology, 49
E. Kloet, J. Reul, W. Sutanto (1990)
Corticosteroids and the brainThe Journal of Steroid Biochemistry and Molecular Biology, 37
J. Altman, S. Bayer (1990)
Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cellsJournal of Comparative Neurology, 301
H. Cameron, R. McKay (1999)
Restoring production of hippocampal neurons in old ageNature Neuroscience, 2
M. Montaron, P. Piazza, C. Aurousseau, A. Urani, M. Moal, D. Abrous (2003)
Implication of corticosteroid receptors in the regulation of hippocampal structural plasticityEuropean Journal of Neuroscience, 18
V. Lemaire, M. Koehl, M. Moal, D. Abrous (2000)
Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America, 97 20
G. Kempermann, H. Kuhn, F. Gage (1998)
Experience-Induced Neurogenesis in the Senescent Dentate GyrusThe Journal of Neuroscience, 18
Becky Stein-Behrens, R. Sapolsky (1992)
Stress, glucocorticoids, and agingAging Clinical and Experimental Research, 4
H. Georg, Kuhn, Heather, Dickinson-Anson, Fred, H. Gage (1996)
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation, 16
Seymour Levine (1970)
The pituitary-adrenal system and the developing brain.Progress in brain research, 32
P. Gass, O. Kretz, D. Wolfer, S. Berger, F. Tronche, H. Reichardt, C. Kellendonk, H. Lipp, W. Schmid, G. Schütz (2000)
Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult miceEMBO reports, 1
J. Herman, R. Spencer (1998)
Regulation of Hippocampal Glucocorticoid Receptor Gene Transcription and Protein Expression In VivoThe Journal of Neuroscience, 18
J. Trejo, E. Carro, I. Torres-Alemán (2001)
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult HippocampusThe Journal of Neuroscience, 21
R. Bender, Sheila Soleymani, A. Brewster, S. Nguyen, H. Beck, G. Mathern, T. Baram (2003)
Enhanced Expression of a Specific Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN) in Surviving Dentate Gyrus Granule Cells of Human and Experimental Epileptic HippocampusThe Journal of Neuroscience, 23
D. Kornack, P. Rakić (1999)
Continuation of neurogenesis in the hippocampus of the adult macaque monkey.Proceedings of the National Academy of Sciences of the United States of America, 96 10
A. Gerth, C. Hatalski, S. Avishai‐Eliner, T. Baram (1998)
Corticotropin releasing hormone antagonist does not prevent adrenalectomy-induced apoptosis in the dentate gyrus of the rat hippocampus.Stress, 2 3
R. Lichtenwalner, M. Forbes, S. Bennett, C. Lynch, W. Sonntag, D. Riddle (2001)
Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesisNeuroscience, 107
J. Herman (1993)
Regulation of adrenocorticosteroid receptor mRNA expression in the central nervous systemCellular and Molecular Neurobiology, 13
J. Altman, G. Das (1965)
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in ratsJournal of Comparative Neurology, 124
H. Praag, B. Christie, T. Sejnowski, F. Gage (1999)
Running enhances neurogenesis, learning, and long-term potentiation in mice.Proceedings of the National Academy of Sciences of the United States of America, 96 23
W. Sonntag, C. Lynch, S. Bennett, A.S Khan, P. Thornton, P. Cooney, R. Ingram, T. McShane, J. Brunso-Bechtold (1999)
Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing ratsNeuroscience, 88
K. Brunson, M. Eghbal‐Ahmadi, R. Bender, Yuncai Chen, T. Baram (2001)
Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stressProceedings of the National Academy of Sciences of the United States of America, 98
S. Bayer, J. Yackel, P. Puri (1982)
Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life.Science, 216 4548
Dong Liu, J. Diorio, B. Tannenbaum, Christian Caldji, D. Francis, Alison Freedman, Shakti Sharma, Deborah Pearson, P. Plotsky, M. Meaney (1997)
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.Science, 277 5332
D. Merrill, R. Karim, Michael Darraq, A. Chiba, M. Tuszynski (2003)
Hippocampal cell genesis does not correlate with spatial learning ability in aged ratsJournal of Comparative Neurology, 459
R. Spencer, E. Young, P. Choo, B. McEwen (1990)
Adrenal steroid type I and type II receptor binding: estimates of in vivo receptor number, occupancy, and activation with varying level of steroidBrain Research, 514
Neurogenesis of dentate gyrus granule cells is generally considered to be negatively regulated by glucocorticoids. We tested the hypothesis that exposure to low plasma corticosteroid levels starting in the early postnatal period enhances granule cell proliferation rate during adulthood. Rat pups were adrenalectomized (ADX) on postnatal day 10 and were then “clamped” throughout life at low corticosterone levels via oral supplementation. Neurogenesis was determined using BrdU immunochemistry at 3 and 12 months in clamped rats as compared with age‐matched, sham‐operated controls. Rate of neurogenesis did not differ between the groups at either 3 or 12 months. It was significantly lower in 12‐month‐old compared with 3‐month‐old rats, despite the presence of an age‐dependent increase of plasma corticosterone only in the sham‐ADX rats. Granule cell layer volume, granule cell density, and granule cell degeneration (determined using apoptotic markers) were indistinguishable in the two groups, further supporting the comparable rate of neurogenesis under differing chronic glucocorticoid levels. In addition, whereas acute deprivation of plasma glucocorticoids (adrenalectomy) in adult rats evoked a burst of granule cell neurogenesis, complete elimination of these hormones (by stopping hormone supplementation) in adult, early‐life ADX/clamped rats did not. These data do not support a simple inverse relationship between chronic plasma glucocorticoid levels and granule cell neurogenesis. Specifically, chronic modulation of glucocorticoid levels commencing early in life evokes additional, adaptive, and compensatory mechanisms that contribute to the regulation of granule cell proliferation. © 2005 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Jan 1, 2005
Keywords: ; ; ; ;
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