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Hippocampal morphology and spatially related behavior in long‐evans and CFY rats

Hippocampal morphology and spatially related behavior in long‐evans and CFY rats Behavioral responses to novelty in an open field and spatial learning in a radial maze with four arms out of eight reinforced were tested in male and female CFY and Long‐Evans rats. Subsequently, the sizes of the total hippocampi and of various hippocampal cell layers and terminal fields at the midseptotemporal level were measured in Timm‐stained sections. No strain differences were found in the open field (except for defecation). In the radial maze, Long‐Evans rats showed better spatial reference memory capabilities than rats of the CFY strain. The relative sizes of the intra‐ and infrapyramidal mossy fiber (IIP‐MF) projections did not differ between the strains. Within the more variable CFY strain, a positive correlation between the size of the IIPMF projection and radial maze performance was found. The absolute sizes of the entire hippocampi and all hippocampal layers at the midseptotemporal level were larger in the CFY strain. The size of the suprapyramidal mossy fiber projection was related to the number of granule cells and to the ratio between granule and CA3 pyramidal cells. In contrast, the size of the IIP‐MF projection did not correlate with either of these variables. The results indicate that the size of the mossy fiber projection may be determined mainly by the available postsynaptic surface on the dendrites of CA3 pyramidal neurons. Furthermore, an increased number of granule cells and their larger projection to the apical dendrites of pyramidal neurons does not appear to result in physiological changes with behavioral consequences. The results also indicate that hippocampal size or the numbers of hippocampal neurons as shown in particular bird and rodent populations is not an indicator of spatial learning capacity in commonly used laboratory rodent strains. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Hippocampal morphology and spatially related behavior in long‐evans and CFY rats

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References (25)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.450030102
pmid
8364679
Publisher site
See Article on Publisher Site

Abstract

Behavioral responses to novelty in an open field and spatial learning in a radial maze with four arms out of eight reinforced were tested in male and female CFY and Long‐Evans rats. Subsequently, the sizes of the total hippocampi and of various hippocampal cell layers and terminal fields at the midseptotemporal level were measured in Timm‐stained sections. No strain differences were found in the open field (except for defecation). In the radial maze, Long‐Evans rats showed better spatial reference memory capabilities than rats of the CFY strain. The relative sizes of the intra‐ and infrapyramidal mossy fiber (IIP‐MF) projections did not differ between the strains. Within the more variable CFY strain, a positive correlation between the size of the IIPMF projection and radial maze performance was found. The absolute sizes of the entire hippocampi and all hippocampal layers at the midseptotemporal level were larger in the CFY strain. The size of the suprapyramidal mossy fiber projection was related to the number of granule cells and to the ratio between granule and CA3 pyramidal cells. In contrast, the size of the IIP‐MF projection did not correlate with either of these variables. The results indicate that the size of the mossy fiber projection may be determined mainly by the available postsynaptic surface on the dendrites of CA3 pyramidal neurons. Furthermore, an increased number of granule cells and their larger projection to the apical dendrites of pyramidal neurons does not appear to result in physiological changes with behavioral consequences. The results also indicate that hippocampal size or the numbers of hippocampal neurons as shown in particular bird and rodent populations is not an indicator of spatial learning capacity in commonly used laboratory rodent strains.

Journal

HippocampusWiley

Published: Jan 1, 1993

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