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References (19)
-
S. Doralp, L. Leung (2008)
Cholinergic modulation of hippocampal CA1 basal-dendritic long-term potentiationNeurobiology of Learning and Memory, 90
-
P. Buckmaster, P. Schwartzkroin (1995)
Interneurons and inhibition in the dentate gyrus of the rat in vivo, 15
-
V. Wilsch, T. Behnisch, T. Jäger, K. Reymann, D. Balschun (1998)
When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?The Journal of Neuroscience, 18
-
L. Bernstein, Suneela Ramineni, C. Hague, W. Cladman, P. Chidiac, A. Levey, J. Hepler (2004)
RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling*Journal of Biological Chemistry, 279
-
J. Saugstad, Michael Marino, Julie Folk, J. Hepler, P. Conn (1998)
RGS4 Inhibits Signaling by Group I Metabotropic Glutamate ReceptorsThe Journal of Neuroscience, 18
-
N. Breakwell, M. Rowan, R. Anwyl (1996)
Metabotropic glutamate receptor dependent EPSP and EPSP-spike potentiation in area CA1 of the submerged rat hippocampal slice.Journal of neurophysiology, 76 5
-
K. Jun, G. Choi, S. Yang, K. Choi, H. Kim, G. Chan, D. Storm, C. Albert, G. Mayr, C. Lee, H. Shin (1998)
Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice.Learning & memory, 5 4-5
-
S. Heximer, N. Watson, M. Linder, K. Blumer, J. Hepler (1997)
RGS2/G0S8 is a selective inhibitor of Gqα functionProceedings of the National Academy of Sciences of the United States of America, 94
-
Jing Han, M. Mark, Xiang Li, Mian Xie, Sayumi Waka, J. Rettig, S. Herlitze (2006)
RGS2 Determines Short-Term Synaptic Plasticity in Hippocampal Neurons by Regulating Gi/o- Mediated Inhibition of Presynaptic Ca2+ ChannelsNeuron, 51
-
T. Kaibara, Ls Leung (1993)
Basal versus apical dendritic long-term potentiation of commissural afferents to hippocampal CA1: a current-source density study, 13
-
A. Roy, C. Nunn, Hong Ming, Min-Xu Zou, J. Penninger, L. Kirshenbaum, S. Dixon, P. Chidiac (2006)
Up-regulation of Endogenous RGS2 Mediates Cross-desensitization between Gs and Gq Signaling in Osteoblasts*Journal of Biological Chemistry, 281
-
T. Ingi, Y. Aoki (2002)
Expression of RGS2, RGS4 and RGS7 in the developing postnatal brainEuropean Journal of Neuroscience, 15
-
Fabian Kloosterman, Pascal Péloquin, L. Leung (2001)
Apical and basal orthodromic population spikes in hippocampal CA1 in vivo show different origins and patterns of propagation.Journal of neurophysiology, 86 5
-
S. Sinnarajah, C. Dessauer, Deepa Srikumar, Jun Chen, Johnny Yuen, Solomon Yilma, J. Dennis, E. Morrison, V. Vodyanoy, J. Kehrl (2001)
RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase IIINature, 409
-
W. Cladman, P. Chidiac (2002)
Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated GiMolecular Pharmacology, 62
-
T. Ingi, A. Krumins, P. Chidiac, G. Brothers, S. Chung, B. Snow, C. Barnes, A. Lanahan, D. Siderovski, E. Ross, A. Gilman, P. Worley (1998)
Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal PlasticityThe Journal of Neuroscience, 18
-
A. Cohen, C. Coussens, C. Raymond, W. Abraham (1999)
Long-lasting increase in cellular excitability associated with the priming of LTP induction in rat hippocampus.Journal of neurophysiology, 82 6
-
A. Oliveira-dos-Santos, G. Matsumoto, B. Snow, D. Bai, F. Houston, I. Whishaw, S. Mariathasan, T. Sasaki, A. Wakeham, P. Ohashi, J. Roder, C. Barnes, D. Siderovski, J. Penninger (2000)
Regulation of T cell activation, anxiety, and male aggression by RGS2.Proceedings of the National Academy of Sciences of the United States of America, 97 22
-
E. Ross, T. Wilkie (2000)
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.Annual review of biochemistry, 69
- Publisher
- Wiley
- Copyright
- Copyright © 2009 Wiley‐Liss, Inc.
- ISSN
- 1050-9631
- eISSN
- 1098-1063
- DOI
- 10.1002/hipo.20582
- pmid
- 19294649
- Publisher site
- See Article on Publisher Site
Abstract
RGS2 is a member of the regulator of G‐protein signaling (RGS) family and has been implicated in cellular mechanisms associated with neuronal plasticity. Long‐term potentiation (LTP) of RGS2 knockout and wild‐type mice was examined at the Schaffer collaterals to CA1 pathway in urethane‐anesthetized mice in vivo to examine RGS2's possible role in the regulation of potentiation. As compared to wild‐type mice, RGS2 knockouts demonstrated much stronger LTP of the extracellular population spikes at the somatic and dendritic layers in CA1 region and more pronounced LTP of the population excitatory postsynaptic current sink. Under baseline conditions, RGS2 knockouts showed lower paired‐pulse facilitation of the excitatory postsynaptic potentials and associated current sinks in vivo as compared with wild‐type mice. The data show for the first time that RGS2 deficient mice in vivo differ from wild‐type mice in both short‐term and long‐term synaptic plasticity suggesting that RGS2 serves as a negative regulator of long‐term synaptic plasticity. © 2009 Wiley‐Liss, Inc.
Journal
Hippocampus – Wiley
Published: Aug 1, 2009