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Hippocampal damage and anterograde object‐recognition in rats after long retention intervals

Hippocampal damage and anterograde object‐recognition in rats after long retention intervals Although several studies in rats have found that hippocampal damage has negligible effects on anterograde object‐recognition memory, the findings are not entirely conclusive, because most studies have used retention intervals lasting only a few hours. We assessed the effects of neurotoxic hippocampal lesions on anterograde object recognition, using a novel‐object preference test, with retention intervals that were considerably longer than in previous studies—24 h, 1 week, and 3 weeks. To promote object recognition after such long intervals, rats were familiarized with a sample object in an open field for 5 min/day for 5 consecutive days. Recognition was assessed by comparing the amount of time spent investigating the sample versus a novel object on a preference test at one of the postlearning intervals. The rats with hippocampal lesions displayed a normal novelty preference after a 3‐week interval, and their performance across the three delay conditions was not significantly different from that of control rats. The findings indicate that extensive hippocampal damage spares anterograde object recognition in rats, even after retention intervals lasting days or weeks. © 2005 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Hippocampal damage and anterograde object‐recognition in rats after long retention intervals

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References (42)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.20122
pmid
16145694
Publisher site
See Article on Publisher Site

Abstract

Although several studies in rats have found that hippocampal damage has negligible effects on anterograde object‐recognition memory, the findings are not entirely conclusive, because most studies have used retention intervals lasting only a few hours. We assessed the effects of neurotoxic hippocampal lesions on anterograde object recognition, using a novel‐object preference test, with retention intervals that were considerably longer than in previous studies—24 h, 1 week, and 3 weeks. To promote object recognition after such long intervals, rats were familiarized with a sample object in an open field for 5 min/day for 5 consecutive days. Recognition was assessed by comparing the amount of time spent investigating the sample versus a novel object on a preference test at one of the postlearning intervals. The rats with hippocampal lesions displayed a normal novelty preference after a 3‐week interval, and their performance across the three delay conditions was not significantly different from that of control rats. The findings indicate that extensive hippocampal damage spares anterograde object recognition in rats, even after retention intervals lasting days or weeks. © 2005 Wiley‐Liss, Inc.

Journal

HippocampusWiley

Published: Jan 1, 2005

Keywords: ; ; ; ;

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