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Highly Efficient Curtius Rearrangement Approach for the Synthesis of Unsymmetrical Sulfonimidoyl Ureas

Highly Efficient Curtius Rearrangement Approach for the Synthesis of Unsymmetrical Sulfonimidoyl... A highly efficient synthesis of unsymmetrical sulfoximine ureas is developed. The reaction unites simple NH‐sulfoximines and acyl azides by a formal Curtius rearrangement as the key step. This reaction could be easily scaled up to gram scale and omits the generation of hazardous byproducts, thus allowing a practical and environmentally benign path for the synthesis of medicinally important sulfonimidoyl unsymmetrical ureas. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Highly Efficient Curtius Rearrangement Approach for the Synthesis of Unsymmetrical Sulfonimidoyl Ureas

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References (74)

Publisher
Wiley
Copyright
© 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201700248
Publisher site
See Article on Publisher Site

Abstract

A highly efficient synthesis of unsymmetrical sulfoximine ureas is developed. The reaction unites simple NH‐sulfoximines and acyl azides by a formal Curtius rearrangement as the key step. This reaction could be easily scaled up to gram scale and omits the generation of hazardous byproducts, thus allowing a practical and environmentally benign path for the synthesis of medicinally important sulfonimidoyl unsymmetrical ureas.

Journal

Asian Journal of Organic ChemistryWiley

Published: Jul 1, 2017

Keywords: ; ; ;

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