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A highly efficient synthesis of unsymmetrical sulfoximine ureas is developed. The reaction unites simple NH‐sulfoximines and acyl azides by a formal Curtius rearrangement as the key step. This reaction could be easily scaled up to gram scale and omits the generation of hazardous byproducts, thus allowing a practical and environmentally benign path for the synthesis of medicinally important sulfonimidoyl unsymmetrical ureas.
Asian Journal of Organic Chemistry – Wiley
Published: Jul 1, 2017
Keywords: ; ; ;
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