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- Publisher
- Wiley
- Copyright
- Copyright © 2013 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 2193-5807
- eISSN
- 2193-5815
- DOI
- 10.1002/ajoc.201300010
- Publisher site
- See Article on Publisher Site
Abstract
The diastereoselective tandem N‐alkylation‐Mannich reaction of α‐imino esters has been achieved by using three sequential reactions: N‐ethylation with diethylaluminum chloride and ethylaluminum chloride, oxidation with benzoyl peroxide (BPO), and addition of lithium enolates or ketene silyl acetals, in which “E”‐ and “Z”‐lithium enolates or E‐ and Z‐ketene silyl acetals give the syn and anti products, respectively. DME=1,2‐dimethoxyethane; PMP=p‐methoxyphenyl.
Journal
Asian Journal of Organic Chemistry – Wiley
Published: Mar 1, 2013
Keywords: ; ; ; ;