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Heritabilities of liability to diabetes when sex and age at onset are considered

Heritabilities of liability to diabetes when sex and age at onset are considered BY NANCY E. SIMPSON From the Departments of Paediatrics and Biology, Queen’s University, Kingston, Ontario INTRODUCTION Many traits and diseases without obvious single-gene inheritance are thought to have some genetic basis since they occur concordantly in monozygotic twins more frequently than in dizygotic twins and they occur more frequently in families than in the general population. The alternative to a single gene hypothesis is multifactorial inheritance in which a number of genes have additive effects with or without environmental influences. I n addition, non-additive genetic effects may occur from dominance and interaction of genes at other loci to produce the phenotype. It is possible to estimate the contribution of the additive genetic variance to the total phenotypic variance for quantitative or continuous traits based on methods developed by Fisher (1918). Fisher showed that the theoretical correlation or regression coefficient between relatives is the same as the proportion of genes which they have in common. For example, parents and children have half their genes in common and, if the regression of the trait in parents on that in their children is 50 %, the characteristic could be inherited by additive genes; if the regression i s not 50 yo http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Heritabilities of liability to diabetes when sex and age at onset are considered

Annals of Human Genetics , Volume 32 (3) – Jan 1, 1969

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References (36)

Publisher
Wiley
Copyright
Copyright © 1969 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1969.tb00077.x
Publisher site
See Article on Publisher Site

Abstract

BY NANCY E. SIMPSON From the Departments of Paediatrics and Biology, Queen’s University, Kingston, Ontario INTRODUCTION Many traits and diseases without obvious single-gene inheritance are thought to have some genetic basis since they occur concordantly in monozygotic twins more frequently than in dizygotic twins and they occur more frequently in families than in the general population. The alternative to a single gene hypothesis is multifactorial inheritance in which a number of genes have additive effects with or without environmental influences. I n addition, non-additive genetic effects may occur from dominance and interaction of genes at other loci to produce the phenotype. It is possible to estimate the contribution of the additive genetic variance to the total phenotypic variance for quantitative or continuous traits based on methods developed by Fisher (1918). Fisher showed that the theoretical correlation or regression coefficient between relatives is the same as the proportion of genes which they have in common. For example, parents and children have half their genes in common and, if the regression of the trait in parents on that in their children is 50 %, the characteristic could be inherited by additive genes; if the regression i s not 50 yo

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 1969

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