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Haptoglobin frequencies in Jewish communities *

Haptoglobin frequencies in Jewish communities * Summary Haptoglobin and transferrin types have been determined by starch gel electrophoresis on blood from 929 subjects belonging to various Jewish communities. The frequency of the Hp1 gene in 499 Ashkenazic Jews is 0.29 and does not differ significantly from the value of 0–26 found in 345 Jews of Oriental origin. The Hp1 frequency of Ashkenazic Jews is significantly lower than that reported for the autochthonous populations of Central and Western Europe. Two small samples collected among Sephardic Jews and among the offspring of intercommunity marriages exhibit somewhat higher frequencies of the Hp1 gene. The modified 2‐1 phenotype was found in a single subject from Baghdad. There were three cases of ahaptoglobinaemia among Ashkenazic Jews and three among the Oriental groups. No ahaptoglobinaemia was discovered in a family sample of ninety‐two Jews from Kurdistan among whom thalassaemia minor was common and the majority of whom were affeeted with G‐6‐P‐D deficiency. All transferrins were of type C. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

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References (59)

Publisher
Wiley
Copyright
Copyright © 1962 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1962.tb01307.x
Publisher site
See Article on Publisher Site

Abstract

Summary Haptoglobin and transferrin types have been determined by starch gel electrophoresis on blood from 929 subjects belonging to various Jewish communities. The frequency of the Hp1 gene in 499 Ashkenazic Jews is 0.29 and does not differ significantly from the value of 0–26 found in 345 Jews of Oriental origin. The Hp1 frequency of Ashkenazic Jews is significantly lower than that reported for the autochthonous populations of Central and Western Europe. Two small samples collected among Sephardic Jews and among the offspring of intercommunity marriages exhibit somewhat higher frequencies of the Hp1 gene. The modified 2‐1 phenotype was found in a single subject from Baghdad. There were three cases of ahaptoglobinaemia among Ashkenazic Jews and three among the Oriental groups. No ahaptoglobinaemia was discovered in a family sample of ninety‐two Jews from Kurdistan among whom thalassaemia minor was common and the majority of whom were affeeted with G‐6‐P‐D deficiency. All transferrins were of type C.

Journal

Annals of Human GeneticsWiley

Published: Sep 1, 1962

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