Access the full text.
Sign up today, get DeepDyve free for 14 days.
Dominique Toran-Allerand, X. Guan, N. MacLusky, T. Horvath, S. Diano, Meharvan Singh, E. Sander, Connolly Jr, I. Nethrapalli, A. Tinnikov, Dominique Toran-Allerand (2002)
ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain InjuryThe Journal of Neuroscience, 22
B. Czéh, T. Welt, A. Fischer, A. Erhardt, Wolfram Schmitt, M. Müller, N. Toschi, E. Fuchs, M. Keck (2002)
Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesisBiological Psychiatry, 52
C. Woolley, E. Gould, M. Frankfurt, B. McEwen (1990)
Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons, 10
Chung Bon-chu, Hu Meng-chun (2002)
Androgen Biosynthesis And Degradation
C. Isgor, S. Watson (2005)
Estrogen receptor α and β mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zoneNeuroscience, 134
W. Mayo, V. Lemaire, J. Malaterre, J. Rodríguez, M. Cayre, M. Stewart, M. Kharouby, G. Rougon, M. Moal, P. Piazza, D. Abrous (2005)
Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampusNeurobiology of Aging, 26
T. Stevenson, G. Bentley, E. Hampson, L. Arckens, S. MacDougall-Shackleton (2005)
Reproductive context and immunoreactivity of chicken gonadotropin-releasing hormones -I and -II in female house sparrows (passer domesticus)Hormones and Behavior, 48
John Morris, C. Jordan, Marc Breedlove (2004)
Sexual differentiation of the vertebrate nervous systemNature Neuroscience, 7
L. Galea, B. Mcewen (1999)
Sex and seasonal differences in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles.Neuroscience, 89 3
T. Schuurman (1980)
Hormonal correlates of agonistic behavior in adult male rats.Progress in brain research, 53
M. Pérez-Martín, Í. Azcoitia, J. Trejo, A. Sierra, L. Garcia-Segura (2003)
An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin‐like growth factor‐I in the dentate gyrus of adult female ratEuropean Journal of Neuroscience, 18
Ormerod Ormerod, Galea Galea (2003)
Reproductive status influences the survival of new cells in the dentate gyrus of adult male meadow volesNuerosci Lett, 346
P. Macdonald, J. Madden, P. Brenner, Jean Wilson, P. Siiteri (1979)
Origin of estrogen in normal men and in women with testicular feminization.The Journal of clinical endocrinology and metabolism, 49 6
Zhang Zhang, Li Li, Ma Ma, Barker Barker, Chang Chang, Zhao Zhao, Rubinow Rubinow (2002)
Dehydroepindrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing waysMolec Brain Res, 98
B. Ormerod, L. Galea (2003)
Reproductive status influences the survival of new cells in the dentate gyrus of adult male meadow volesNeuroscience Letters, 346
Philippe Absil, R. Pinxten, J. Balthazart, M. Eens (2003)
Effect of age and testosterone on autumnal neurogenesis in male European starlings (Sturnus vulgaris)Behavioural Brain Research, 143
N. Weiland, C. Orikasa, S. Hayashi, B. McEwen (1997)
Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female ratsJournal of Comparative Neurology, 388
J. Rosenblatt, A. Mayer, A. Giordano (1988)
Hormonal basis during pregnancy for the onset of maternal behavior in the ratPsychoneuroendocrinology, 13
P. Tanapat, N. Hastings, E. Gould (2005)
Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose‐ and time‐dependent mannerJournal of Comparative Neurology, 481
A. Álvarez-Buylla, J. Kirn (1997)
Birth, migration, incorporation, and death of vocal control neurons in adult songbirds.Journal of neurobiology, 33 5
D. Hemsell, J. Grodin, P. Brenner, P. Siiteri, P. Macdonald (1974)
Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age.The Journal of clinical endocrinology and metabolism, 38 3
Chawnshang Chang (2002)
Androgens and androgen receptor : mechanisms, functions, and clinical applications
C. Wood (2005)
Estrogen/Hypothalamus-Pituitary-Adrenal Axis Interactions in the Fetus: the Interplay Between Placenta and Fetal BrainJournal of the Society for Gynecologic Investigation, 12
E. Gould, B. McEwen, P. Tanapat, L. Galea, E. Fuchs (1997)
Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor ActivationThe Journal of Neuroscience, 17
J. Kerr, R. Allore, S. Beck, R. Handa (1995)
Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus.Endocrinology, 136 8
V. Pravosudov, Alicja Omanska (2005)
Dominance-related changes in spatial memory are associated with changes in hippocampal cell proliferation rates in mountain chickadees.Journal of neurobiology, 62 1
S. Rasika, F. Nottebohm, A. Álvarez-Buylla (1994)
Testosterone increases the recruitment and/or survival of new high vocal center neurons in adult female canaries.Proceedings of the National Academy of Sciences of the United States of America, 91 17
T. Shingo, C. Gregg, E. Enwere, Hirokazu Fujikawa, R. Hassam, Colleen Geary, J. Cross, S. Weiss (2003)
Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by ProlactinScience, 299
Katarzyna Kalita, S. Szymczak, L. Kaczmarek (2005)
Non‐nuclear estrogen receptor β and α in the hippocampus of male and female ratsHippocampus, 15
S. Weill‐Engerer, J. David, V. Sazdovitch, P. Liere, B. Eychenne, A. Pianos, M. Schumacher, A. Delacourte, E. Baulieu, Y. Akwa (2002)
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.The Journal of clinical endocrinology and metabolism, 87 11
C. Orikasa, B. McEwen, H. Hayashi, Y. Sakuma, S. Hayashi (2000)
Estrogen receptor alpha, but not beta, is expressed in the interneurons of the hippocampus in prepubertal rats: an in situ hybridization study.Brain research. Developmental brain research, 120 2
D. Blanchard, R. Sakai, B. McEwen, S. Weiss, R. Blanchard (1993)
Subordination stress: Behavioral, brain, and neuroendocrine correlatesBehavioural Brain Research, 58
M. Banasr, Micheline Héry, J. Brezun, A. Daszuta (2001)
Serotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrusEuropean Journal of Neuroscience, 14
A. Concas, M. Mostallino, P. Porcu, P. Follesa, M. Barbaccia, M. Trabucchi, R. Purdy, P. Grisenti, G. Biggio (1998)
Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.Proceedings of the National Academy of Sciences of the United States of America, 95 22
K. Karishma, Joe Herbert (2002)
Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone‐induced suppressionEuropean Journal of Neuroscience, 16
S. Rasika, A. Álvarez-Buylla, F. Nottebohm (1999)
BDNF Mediates the Effects of Testosterone on the Survival of New Neurons in an Adult BrainNeuron, 22
E. Gould, P. Tanapat, B. McEwen, G. Flügge, E. Fuchs (1998)
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress.Proceedings of the National Academy of Sciences of the United States of America, 95 6
Monique Vallée, Willy Mayo, Muriel Darnaudéry, C. Corpéchot, J. Young, Muriel Koehl, M. Moal, E. Baulieu, P. Robel, Hervé Simon (1997)
Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America, 94 26
Nagy Nagy, Pawluski Pawluski, Ormerod Ormerod, Mazzucco Mazzucco, Galea Galea
Estradiol‐induced enhancement in cell proliferation is mediated through estrogen receptors in the dentate gyrus of adult female ratsDrug Develop Res
H. Bimonte-Nelson, R. Singleton, M. Nelson, C. Eckman, J. Barber, Tonetta Scott, A. Granholm (2003)
Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male ratsExperimental Neurology, 181
(2005)
Neurogenesis via cell survival is not altered with motherhood
Y. Kozorovitskiy, E. Gould (2004)
Dominance Hierarchy Influences Adult Neurogenesis in the Dentate GyrusThe Journal of Neuroscience, 24
Masatoshi Suzuki, L. Wright, P. Marwah, H. Lardy, C. Svendsen (2004)
Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex.Proceedings of the National Academy of Sciences of the United States of America, 101 9
B. Ormerod, T. Lee, L. Galea (2004)
Estradiol enhances neurogenesis in the dentate gyri of adult male meadow voles by increasing the survival of young granule neuronsNeuroscience, 128
Katarzyna Kalita, S. Szymczak, L. Kaczmarek (2005)
Non-nuclear estrogen receptor beta and alpha in the hippocampus of male and female rats.Hippocampus, 15 3
K. Brännvall, L. Korhonen, D. Lindholm (2002)
Estrogen-Receptor-Dependent Regulation of Neural Stem Cell Proliferation and DifferentiationMolecular and Cellular Neuroscience, 21
G. Mckhann (2005)
VEGF Links Hippocampal Activity with Neurogenesis, Learning, and Memory.Neurosurgery, 56 1
Lei Zhang, Bing Li, Wu Ma, J. Barker, Y. Chang, Weiqin Zhao, D. Rubinow (2002)
Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways.Brain research. Molecular brain research, 98 1-2
Sd Brown, F. Johnson, SW Bottjer (1993)
Neurogenesis in adult canary telencephalon is independent of gonadal hormone levels, 13
Orikasa Orikasa, McEwen McEwen, Hayashi Hayashi, Sakuma Sakuma, Hayashi Hayashi (2000)
Estrogen receptor alpha, but not beta, is expressed in the interneurons of the hippocampus in prepubertal rats: an in situ hybridization studyDev Brain Res, 120
(2005)
Androgens enhance cell survival but not cell proliferation in adult male rats
B. Ormerod, Tiffany Lee, L. Galea, L. Galea (2003)
Estradiol initially enhances but subsequently suppresses (via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats.Journal of neurobiology, 55 2
V. Stefanski (2000)
Social stress in laboratory rats: hormonal responses and immune cell distributionPsychoneuroendocrinology, 25
P. Tanapat, N. Hastings, Alison Reeves, E. Gould (1999)
Estrogen Stimulates a Transient Increase in the Number of New Neurons in the Dentate Gyrus of the Adult Female RatThe Journal of Neuroscience, 19
J. Grodin, P. Siiteri, P. Macdonald (1973)
Source of estrogen production in postmenopausal women.The Journal of clinical endocrinology and metabolism, 36 2
L. Garcia-Segura, A. Wozniak, Í. Azcoitia, J. Rodríguez, R. Hutchison, J. Hutchison (1999)
Aromatase expression by astrocytes after brain injury: implications for local estrogen formation in brain repairNeuroscience, 89
V. Pravosudov, S. Mendoza, N. Clayton (2003)
The relationship between dominance, corticosterone, memory, and food caching in mountain chickadees (Poecile gambeli)Hormones and Behavior, 44
E. Baulieu (1997)
Neurosteroids: of the nervous system, by the nervous system, for the nervous system.Recent progress in hormone research, 52
J. Wang, P. Johnston, B. Ball, R. Brinton (2005)
The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein ExpressionThe Journal of Neuroscience, 25
N. Hastings, E. Gould (1999)
Rapid extension of axons into the CA3 region by adult‐generated granule cellsJournal of Comparative Neurology, 413
C. Fowler, M. Freeman, Zuoxin Wang (2003)
Newly proliferated cells in the adult male amygdala are affected by gonadal steroid hormones.Journal of neurobiology, 57 3
L. Galea, T. Perrot-Sinal, M. Kavaliers, K. Ossenkopp (1999)
Relations of hippocampal volume and dentate gyrus width to gonadal hormone levels in male and female meadow volesBrain Research, 821
L. Galea, B. McEwen (1999)
Sex and seasonal changes in the rate of cell proliferation in the dentate gyrus of adult wild meadow volesNeuroscience, 89
K. Brännvall, N. Bogdanovic, L. Korhonen, D. Lindholm (2005)
19‐Nortestosterone influences neural stem cell proliferation and neurogenesis in the rat brainEuropean Journal of Neuroscience, 21
Susan Lee, Bruce McEwen (2001)
Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications.Annual review of pharmacology and toxicology, 41
Jaewon Lee, W. Duan, M. Mattson (2002)
Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult miceJournal of Neurochemistry, 82
Pawluski Pawluski, Leiblich Leiblich, Shum Shum, Galea Galea
Estradiol affects cell proliferation in the dentate gyrus differentally in adult male and female ratsSynapse
M. Darnaudéry, M. Pallarés, P. Piazza, M. Moal, W. Mayo (2002)
The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in ratsBrain Research, 951
B. Ormerod, L. Galea (2001)
Reproductive status influences cell proliferation and cell survival in the dentate gyrus of adult female meadow voles: a possible regulatory role for estradiolNeuroscience, 102
P. Macdonald, C. Edman, I. Kerber, P. Siiteri (1976)
Plasma Precursors of EstrogenGynecologic and Obstetric Investigation, 7
A. Louissaint, Sudha Rao, Caroline Leventhal, S. Goldman (2002)
Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird BrainNeuron, 34
M. Blurton-Jones, P.N. Kuan, M. Tuszynski (2004)
Anatomical evidence for transsynaptic influences of estrogen on brain‐derived neurotrophic factor expressionJournal of Comparative Neurology, 468
M. Simón, B. Czéh, E. Fuchs (2005)
Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stressBrain Research, 1049
M. Vallée, W. Mayo, M. Moal (2001)
Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive agingBrain Research Reviews, 37
C. Isgor, S. Watson (2005)
Estrogen receptor alpha and beta mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone.Neuroscience, 134 3
J. Gold (1998)
Gender differences in psychiatric illness and treatments: a critical review.The Journal of nervous and mental disease, 186 12
Gonadal hormones modulate neurogenesis in the dentate gyrus (DG) of adult rodents in complex ways. Estradiol, the most potent estrogen, initially enhances and subsequently suppresses cell proliferation in the dentate gryus of adult female rodents. Much less is known about how estradiol modulates neurogenesis in the adult male rodent; however, recent evidence suggests that estradiol may have a moderate effect on cell proliferation but enhances cell survival in the DG of newly synthesized cells but only when estradiol is administered during a specific stage in the cell maturation cycle in the adult male rodent. Testosterone likely plays a role in adult neurogenesis, although there have been no direct studies to address this. However, pilot studies from our laboratory suggest that testosterone up‐regulates cell survival but not cell proliferation in the DG of adult male rats. Progesterone appears to attenuate the estradiol‐induced enhancement of cell proliferation. Neurosteroids such as allopregnalone decrease neurogenesis in adult rodents, while pregnancy and motherhood differentially regulate adult neurogenesis in the adult female rodent. Very few studies have investigated the effects of gonadal hormones on male rodents; however, studies have indicated that there is a gender difference in the response to hormone‐regulated hippocampal neurogenesis in the adult. Clearly, more work needs to be done to elucidate the effects of gonadal hormones on neurogenesis in the DG of both male and female rodents. © 2006 Wiley‐Liss Inc.
Hippocampus – Wiley
Published: Jan 1, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.