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- Publisher
- Wiley
- Copyright
- © 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
- ISSN
- 2192-6506
- eISSN
- 2192-6506
- DOI
- 10.1002/cplu.201500531
- Publisher site
- See Article on Publisher Site
Abstract
Cyclodextrin‐based nanosponges are designed as new nanostructured material for drug delivery. In vitro and in vivo studies show that nanosponges can increase the effectiveness of anti‐cancer drugs encapsulated within their nanostructure. Reported is a new, cheap glutathione (GSH)‐responsive material easily obtained in high yield through a one‐step synthetic route. Effectiveness of this GSH‐responsive material was proved using several tumor cells and doxorubicin as model anticancer drug. The release of the drug was in according with the GSH content in tumor cells.
Journal
ChemPlusChem – Wiley
Published: May 1, 2016
Keywords: ; ; ; ;