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Genetics of paraoxonase

Genetics of paraoxonase SUMMARY Danish family material comprising 1664 unrelated individuals (parents) and 3169 children, as well as 699 grandparents of the same families, were examined for paraoxonase activity. A micro‐autoanalyser method, comprising a primary testing in tris buffer at pH 7‐5 and, in the case of primarily intermediate individuals, a secondary testing at pH 10, was applied. This gave a better discrimination than testing only at pH 7.5, because individuals around the low mode of the primary activity distribution had their pH optimum at pH 10, while the optimum of individuals around the high was at pH 8.5. By this combined testing all individuals could be unequivocally classified as ‘low’ or ‘high’, and the family material was compatible with the low phenotype representing homozygosity for an autosomal recessive gene with a frequency Plow= 0–726. Out of 5532 individuals, 5 showed an almost complete lack of paraoxonase activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Genetics of paraoxonase

Annals of Human Genetics , Volume 45 (4) – Oct 1, 1981

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References (15)

Publisher
Wiley
Copyright
Copyright © 1981 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1981.tb00345.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY Danish family material comprising 1664 unrelated individuals (parents) and 3169 children, as well as 699 grandparents of the same families, were examined for paraoxonase activity. A micro‐autoanalyser method, comprising a primary testing in tris buffer at pH 7‐5 and, in the case of primarily intermediate individuals, a secondary testing at pH 10, was applied. This gave a better discrimination than testing only at pH 7.5, because individuals around the low mode of the primary activity distribution had their pH optimum at pH 10, while the optimum of individuals around the high was at pH 8.5. By this combined testing all individuals could be unequivocally classified as ‘low’ or ‘high’, and the family material was compatible with the low phenotype representing homozygosity for an autosomal recessive gene with a frequency Plow= 0–726. Out of 5532 individuals, 5 showed an almost complete lack of paraoxonase activity.

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1981

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