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Thomas Owley, Camille Brune, Jeff Salt, Laura Walton, Stephen Guter, Nelson Ayuyao, R. Gibbons, B. Leventhal, E. Cook (2009)
A pharmacogenetic study of escitalopram in autism spectrum disordersAutism Research, 3
E. Brodkin, Andrea Hagemann, S. Nemetski, L. Silver (2004)
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Jessica Burket, W. Cannon, Luis Jacome, S. Deutsch (2010)
MK-801, a noncompetitive NMDA receptor antagonist, elicits circling behavior in the genetically inbred Balb/c mouse strainBrain Research Bulletin, 83
S. Moy, Jessica Nadler, N. Young, Antonio Perez, L. Holloway, R. Barbaro, Justin Barbaro, Lindsay Wilson, D. Threadgill, J. Lauder, Terry Magnuson, J. Crawley, J. Crawley (2007)
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strainsBehavioural Brain Research, 176
E. Billingslea, J. Mastropaolo, R. Rosse, A. Bellack, S. Deutsch (2003)
Interaction of stress and strain on glutamatergic neurotransmission: relevance to schizophreniaPharmacology Biochemistry and Behavior, 74
S. Deutsch, Jessica Burket, Luis Jacome, W. Cannon, Amy Herndon (2011)
d-Cycloserine improves the impaired sociability of the Balb/c mouseBrain Research Bulletin, 84
J. Crawley (2007)
Mouse Behavioral Assays Relevant to the Symptoms of Autism *Brain Pathology, 17
Tobias Halene, R. Ehrlichman, Yuling Liang, E. Christian, G. Jonak, T. Gur, J. Blendy, H. Dow, E. Brodkin, Frank Schneider, Frank Schneider, R. Gur, S. Siegel (2009)
Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophreniaGenes, 8
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A Mouse Model System for Genetic Analysis of Sociability: C57BL/6J Versus BALB/cJ Inbred Mouse StrainsBiological Psychiatry, 59
S. Deutsch, J. Mastropaolo, D. Powell, R. Rosse, S. Bachus (1998)
Inbred Mouse Strains Differ in Their Sensitivity to an Antiseizure Effect of MK‐801Clinical Neuropharmacology, 21
Luis Jacome, Jessica Burket, Amy Herndon, W. Cannon, S. Deutsch (2011)
D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strainBrain Research Bulletin, 84
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Inbred Mouse Strains Differ in Sensitivity to “Popping” Behavior Elicited by MK-801Pharmacology Biochemistry and Behavior, 57
Deborah Norris, J. Mastropaolo, D. O'Connor, Monica Novitzki, S. Deutsch (1992)
Glycinergic interventions potentiate the ability of MK 801 to raise the threshold voltage for tonic hindlimb extension in micePharmacology Biochemistry and Behavior, 43
Diego Mugno, L. Ruta, V. D'Arrigo, L. Mazzone (2007)
Impairment of quality of life in parents of children and adolescents with pervasive developmental disorderHealth and Quality of Life Outcomes, 5
J. Silverman, Seda Tolu, Charlotte Barkan, J. Crawley (2010)
Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEPNeuropsychopharmacology, 35
J. Crawley (2004)
Designing mouse behavioral tasks relevant to autistic-like behaviors.Mental retardation and developmental disabilities research reviews, 10 4
Deborah Norris, J. Mastropaolo, D. O'Connor, Joshua Cohen, S. Deutsch (1994)
A glycinergic intervention potentiates the antiseizure efficacies of MK-801, flurazepam, and carbamazepineNeurochemical Research, 19
Jessica Burket, Amy Herndon, S. Deutsch (2010)
Locomotor activity of the genetically inbred Balb/c mouse strain is suppressed by a socially salient stimulusBrain Research Bulletin, 83
C. McDougle, L. Scahill, M. Aman, J. McCracken, E. Tierney, M. Davies, L. Arnold, D. Posey, Andrés Martin, J. Ghuman, Bhavik Shah, Shirley Chuang, N. Swiezy, N. Gonzalez, Jill Hollway, Kathleen Koenig, J. McGough, Louise Ritz, B. Vitiello (2005)
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Mu Yang, Kayla Perry, Michael Weber, Adam Katz, J. Crawley (2011)
Social peers rescue autism‐relevant sociability deficits in adolescent miceAutism Research, 4
E. Brodkin (2007)
BALB/c mice: Low sociability and other phenotypes that may be relevant to autismBehavioural Brain Research, 176
The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor‐mediated neurotransmission. A standard procedure was used to measure sociability in 8‐week‐old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter‐rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, “stereotypic” behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and “restricted repetitive and stereotyped patterns of behavior” are independent of each other in the Balb/c strain. Autism Res 2011,4:393–400. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.
Autism Research – Wiley
Published: Dec 1, 2011
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