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C. Steel (1972)
A study of human lymphoblastoid cell lines in tissue culture
S. Povey, G. Corney, W. Lewis, E. Robson, J. Parrington, H. Harris (1972)
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Cytological mapping of human chromosomes. Results obtained with quinacrine fluorescence and the acetic‐saline‐Giemsa techniquesChromosoma, 35
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Assignment of the genes for human peptidase A to chromosome 18 and cytoplasmic glutamic oxaloacetate transaminase to chromosome 10 using somatic-cell hybrids.Cytogenetics and cell genetics, 12 3
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Virus containing lymphocyte cultures from cancer patients.Journal of the National Cancer Institute, 39 4
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Localisation of structural gene for human peptidase - A to chromosome 18
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Differences between the N-acetyl and dead ascites cells. E x p . Cell Res. 15, 112. human red cell Peptidase A activity
S. Povey, S. Gardiner, B. Watson, Susan Mowbray, H. Harris, E. Arthur, C. Steel, C. Blenkinsop, H. Evans (1973)
Genetic studies on human lymphoblastoid lines: isozyme analysis on cell lines from forty‐one different individuals and on mutants produced following exposure to a chemical mutagenAnnals of Human Genetics, 36
D. Swallow, D. Stokes, G. Corney, H. Harris (1974)
Differences between the N‐acetyl hexosaminidase isozymes in serum and tissuesAnnals of Human Genetics, 37
N. Davidson (1973)
Photographic techniques for recording chromosome banding patterns.Journal of Medical Genetics, 10
W. Lewis, H. Harris (1967)
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The P-locus position effect in Oenothera.Journal of genetics, 48 1
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B. Cattanach, J. Isaacson (1967)
Controlling elements in the mouse X chromosome.Genetics, 57 2
(1974)
Exclusion of the Peptidase A structural gene locus from the qllq 21 region of chromosome 18 in man
Sinha Sinha, Lewis Lewis, Corney Corney, Harris Harris (1970)
Studies on the quantitative variation of human red cell Peptidase A activityAnn. Hum. Uenet., Lond., 34
Genetic studies on human lymphoblastoid cell lines : isozyme and cytogenetic heterogeneity in a cell line, with evidence for localization of the Pep A locus in man BY ELIZABETH ARTHUR, C. M. STEEL AND H. J. EVANS Medical Research Council, Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh SUSAN POVEY, B. WATSON AND HARRY HARRIS Medical Research Council, Human Biochemical Genetics Unit, Galton Laboratory, University College London I n a series of experiments previously described (Povey et al. 1973) four possible mutations were found among the cloned progeny of a human male lymphoblastoid cell line (F137) after exposure to the chemical mutagen MNNG. We now present data from a further 133 clones (60 mutagen-treated, 73 controls) from the same line. On both cytogenetic and isosyme analysis there is evidence for genetic heterogeneity in the parent line due to the spontaneous emergence of mutant clones under normal culture conditions. This has important implications for the use of such lines in genetic experiments. Examination of the data with particular reference to the enzyme Peptidase A provides strong evidence for localization of the human Pep A structural locus on the qter region of chromosome 18 and gives the first indication
Annals of Human Genetics – Wiley
Published: Jul 1, 1975
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