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Genetic markers of immunoglobulins in Japanese families Inheritance of associated markers belonging to one IgA and three IgG subclasses

Genetic markers of immunoglobulins in Japanese families Inheritance of associated markers... Genetic markers of immunoglobulins in Japanese families Inheritance of associated markers belonging to one IgA and three IgG subclasses BY ERNA VAN LOGHEM Central Laboratory of the Netherlands Red Cross Blood T r a m j w i o n Service, Amsterdam J. B. NATVIG Research Imtitute of Rheuwmtology, Oslo H. MATSUMOTO Osaka Medical College, Osaka AND Gammaglobulin chains are determined by genes in at least two independent linkage groups, Gm and Inv. The respective genes control the synthesis of heavy and light chains respectively. For each linkage group several alleles are known (van Loghem & Mh-tensson, 1967; Natvig & Kunkel, 1968). There are at least four y-cistrons which determine the four IgG subclasses: IgG 1 , IgG2, IgG3 and IgG4 (in earlier nomenclature called y,,,, yay yZcand y2dor We, Ne, Vi and Ge).In three of these IgG subclasses, genetic markers are known. Likewise the class of IgA immunoglobulinscomprises more than one subclass of IgA molecules, distinguished by different heavy chains so that several a-cistrons determine the respective IgA subclasses (Feinstein & Franklin, 1966; Kunkel & Prendergast, 1966; Vmrman & Heremans, 1966).Recently a new genetic marker for heavy chains of IgA, molecules, Am,, has been described (Kunkel, Smith http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Genetic markers of immunoglobulins in Japanese families Inheritance of associated markers belonging to one IgA and three IgG subclasses

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References (22)

Publisher
Wiley
Copyright
Copyright © 1970 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1970.tb01661.x
Publisher site
See Article on Publisher Site

Abstract

Genetic markers of immunoglobulins in Japanese families Inheritance of associated markers belonging to one IgA and three IgG subclasses BY ERNA VAN LOGHEM Central Laboratory of the Netherlands Red Cross Blood T r a m j w i o n Service, Amsterdam J. B. NATVIG Research Imtitute of Rheuwmtology, Oslo H. MATSUMOTO Osaka Medical College, Osaka AND Gammaglobulin chains are determined by genes in at least two independent linkage groups, Gm and Inv. The respective genes control the synthesis of heavy and light chains respectively. For each linkage group several alleles are known (van Loghem & Mh-tensson, 1967; Natvig & Kunkel, 1968). There are at least four y-cistrons which determine the four IgG subclasses: IgG 1 , IgG2, IgG3 and IgG4 (in earlier nomenclature called y,,,, yay yZcand y2dor We, Ne, Vi and Ge).In three of these IgG subclasses, genetic markers are known. Likewise the class of IgA immunoglobulinscomprises more than one subclass of IgA molecules, distinguished by different heavy chains so that several a-cistrons determine the respective IgA subclasses (Feinstein & Franklin, 1966; Kunkel & Prendergast, 1966; Vmrman & Heremans, 1966).Recently a new genetic marker for heavy chains of IgA, molecules, Am,, has been described (Kunkel, Smith

Journal

Annals of Human Genetics – Wiley

Published: May 1, 1970

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