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General purpose probability models in histocompatibility testing. I ‘Strong’ and ‘weak’ alleles at one locus.

General purpose probability models in histocompatibility testing. I ‘Strong’ and ‘weak’ alleles... General purpose probability models in histocompatibility testing. I ‘Strong ’ and ‘weak ’ alleles at one locus. BY REGINA C . ELANDT-JOHNSON” Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, U.S.A. I . INTRODUCTION. IMMUNOGENETIC MECHANISM OF HISTOCOMPATIBILITY 1.1. The general model for allotransplantation of tissue is ‘immunogenetic ’, and its basic concepts of response are very much similar to those in blood transfusion. Where the donor possesses an antigen (or antigens), called ‘histocompatibility antigen(s) ’, which is lacking in the recipient, antibodies against the donor’s antigen(s) are manufactured (mostly in lymph nodes and spleen) and, after a certain time, the graft is rejected. But if the recipient has at least all the antigens possessed by the donor, the graft should be accepted. The tissue compatibility (histocompatibility) is under genetic control; that is, the histocompatibility antigens are the gene products. We do not attempt here to discuss the possible relations: gene-antigen-antibody, since the terminology is not clearlyestablished. There is someevidence that, for example, the relatively wellknown histocompatibility locus H-2 in mouse is really a H - 2 ‘region ’ (or ‘complex locus’). Each ‘ site ’ (or pseudo-allele) controls one antigenic specificity (or determinant) which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

General purpose probability models in histocompatibility testing. I ‘Strong’ and ‘weak’ alleles at one locus.

Annals of Human Genetics , Volume 31 (3) – Jan 1, 1968

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References (17)

Publisher
Wiley
Copyright
Copyright © 1968 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1968.tb00560.x
Publisher site
See Article on Publisher Site

Abstract

General purpose probability models in histocompatibility testing. I ‘Strong ’ and ‘weak ’ alleles at one locus. BY REGINA C . ELANDT-JOHNSON” Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, U.S.A. I . INTRODUCTION. IMMUNOGENETIC MECHANISM OF HISTOCOMPATIBILITY 1.1. The general model for allotransplantation of tissue is ‘immunogenetic ’, and its basic concepts of response are very much similar to those in blood transfusion. Where the donor possesses an antigen (or antigens), called ‘histocompatibility antigen(s) ’, which is lacking in the recipient, antibodies against the donor’s antigen(s) are manufactured (mostly in lymph nodes and spleen) and, after a certain time, the graft is rejected. But if the recipient has at least all the antigens possessed by the donor, the graft should be accepted. The tissue compatibility (histocompatibility) is under genetic control; that is, the histocompatibility antigens are the gene products. We do not attempt here to discuss the possible relations: gene-antigen-antibody, since the terminology is not clearlyestablished. There is someevidence that, for example, the relatively wellknown histocompatibility locus H-2 in mouse is really a H - 2 ‘region ’ (or ‘complex locus’). Each ‘ site ’ (or pseudo-allele) controls one antigenic specificity (or determinant) which

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 1968

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