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P. Massey, Ben Johnson, P. Moult, Y. Auberson, Malcolm Brown, E. Molnár, G. Collingridge, Z. Bashir (2004)
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term DepressionThe Journal of Neuroscience, 24
N. Madroñal, J. Delgado-García, A. Gruart (2007)
Differential Effects of Long-Term Potentiation Evoked at the CA3–CA1 Synapse before, during, and after the Acquisition of Classical Eyeblink Conditioning in Behaving MiceThe Journal of Neuroscience, 27
Sven Berberich, Pradeep Punnakkal, V. Jensen, V. Pawlak, P. Seeburg, Ø. Hvalby, G. Köhr (2005)
Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term PotentiationThe Journal of Neuroscience, 25
J. Larson, Darryl Wong, G. Lynch (1986)
Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiationBrain Research, 368
E. Bienenstock, L. Cooper, P. Munro (1982)
Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex, 2
A. Kemp, D. Manahan‐Vaughan (2008)
The hippocampal CA1 region and dentate gyrus differentiate between environmental and spatial feature encoding through long-term depression.Cerebral cortex, 18 4
Neal Lemon, D. Manahan‐Vaughan (2006)
Dopamine D 1 / D 5 Receptors Gate the Acquisition of Novel Information through Hippocampal Long-Term Potentiation and Long-Term Depression
B. Hogan, Jeffrey Williams (1981)
Integration of foreign genes into the mammalian germ line: genetic engineering enters a new eraNature, 294
Xiao‐lei Zhang, John Sullivan, J. Moskal, P. Stanton (2008)
A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampusNeuropharmacology, 55
U. Staubli, G. Lynch (1987)
Stable hippocampal long-term potentiation elicited by ‘theta’ pattern stimulationBrain Research, 435
W. Morishita, Wei Lu, Gordon Smith, R. Nicoll, M. Bear, R. Malenka (2007)
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depressionNeuropharmacology, 52
F. Costantini, E. Lacy (1981)
Introduction of a rabbit beta-globin gene into the mouse germ line.Nature, 294 5836
P. Nguyen, S. Duffy, J. Young (2000)
Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice.Journal of neurophysiology, 84 5
A. Gruart, J. Delgado-García (2007)
Activity‐dependent changes of the hippocampal CA3–CA1 synapse during the acquisition of associative learning in conscious miceGenes, 6
L. Grover, T. Teyler (1990)
Two components of long-term potentiation induced by different patterns of afferent activationNature, 347
Bihua Feng, R. Morley, D. Jane, D. Monaghan (2005)
The effect of competitive antagonist chain length on NMDA receptor subunit selectivityNeuropharmacology, 48
M. Korte, L. Minichiello, R. Klein, T. Bonhoeffer (2000)
Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiationNeuropharmacology, 39
P. Nguyen, E. Kandel (1997)
Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring cAMP in area CA1 of the mouse hippocampus.Learning & memory, 4 2
R. Palmiter, R. Brinster, R. Hammer, M. Trumbauer, M. Rosenfeld, N. Birnberg, R. Evans (1982)
Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genesNature, 300
Erna Aescht, Simone Büchl-Zimmermann, A. Burmester, Stefan Dänhardt-Pfeiffer, Christine Desel, C. Hamers, Guido Jach, M. Kässens, J. Makovitzky, M. Mulisch, Barbara Nixdorf-Bergweiler, Detlef Pütz, Bernd Riedelsheimer, F. Boom, Rainer Wegerhoff, U. Welsch (2010)
Romeis - Mikroskopische Technik
N. Kemp, Jane McQueen, Suzanna Faulkes, Z. Bashir (2000)
Different forms of LTD in the CA1 region of the hippocampus: role of age and stimulus protocolEuropean Journal of Neuroscience, 12
N. Madroñal, A. Gruart, O. Valverde, Isabel Espadas, R. Moratalla, J. Delgado-García (2012)
Involvement of cannabinoid CB1 receptor in associative learning and in hippocampal CA3-CA1 synaptic plasticity.Cerebral cortex, 22 3
G. Riedel, T. Seidenbecher, K. Reymann (1994)
LTP in hippocampal CA1 of urethane-narcotized rats requires stronger tetanization parametersPhysiology & Behavior, 55
S. Dudek, M. Bear (1992)
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.Proceedings of the National Academy of Sciences of the United States of America, 89
C. Stevens, J. Sullivan (1998)
Synaptic plasticityCurrent Biology, 8
A. Gruart, M. Muñoz, J. Delgado-García (2006)
Involvement of the CA3–CA1 Synapse in the Acquisition of Associative Learning in Behaving MiceThe Journal of Neuroscience, 26
(1986)
Patterned stimulation at the theta
Lidong Liu, T. Wong, M. Pozza, K. Lingenhoehl, Yushan Wang, M. Sheng, Y. Auberson, Y. Wang (2004)
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic PlasticityScience, 304
T. Straube, V. Korz, D. Balschun, J. Frey (2003)
Requirement of β‐adrenergic receptor activation and protein synthesis for LTP‐reinforcement by novelty in rat dentate gyrusThe Journal of Physiology, 552
A. Kemp, D. Manahan‐Vaughan (2005)
The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region in vivo.Cerebral cortex, 15 7
Neal Lemon, D. Manahan‐Vaughan (2011)
Dopamine D1/D5 Receptors Contribute to De Novo Hippocampal LTD Mediated by Novel Spatial Exploration or Locus Coeruleus ActivityCerebral Cortex (New York, NY), 22
T. Straube, Julietta Frey (2003)
Involvement of β-adrenergic receptors in protein synthesis-dependent late long-term potentiation (LTP) in the dentate gyrus of freely moving rats: the critical role of the LTP induction strengthNeuroscience, 119
J. Gordon, F. Ruddle (1981)
Integration and stable germ line transmission of genes injected into mouse pronuclei.Science, 214 4526
R. Malenka, M. Bear (2004)
LTP and LTD An Embarrassment of RichesNeuron, 44
K. Michaelsen, M. Zagrebelsky, J. Berndt-Huch, M. Polack, A. Buschler, M. Sendtner, M. Korte (2010)
Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neuronsEuropean Journal of Neuroscience, 32
T. Bliss, R. Schoepfer (2004)
Controlling the Ups and Downs of Synaptic StrengthScience, 304
K. Huber, J. Roder, M. Bear (2001)
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.Journal of neurophysiology, 86 1
(1992)
Homosynaptic long-term depression
Yuan Ge, Z. Dong, R. Bagot, J. Howland, A. Phillips, T. Wong, Yu Wang (2010)
Hippocampal long-term depression is required for the consolidation of spatial memoryProceedings of the National Academy of Sciences, 107
D. McGehee (2009)
Nicotine's AllureNeuron, 63
(2011)
Dopamine D1/D5 receptors
A. Kemp, D. Manahan‐Vaughan (2011)
Passive Spatial Perception Facilitates the Expression of Persistent Hippocampal Long-Term DepressionCerebral Cortex (New York, NY), 22
(2012)
Involvement of cannabinoid CB1 receptor
J. Koranda, S. Masino, J. Blaise (2008)
Bidirectional synaptic plasticity in the dentate gyrus of the awake freely behaving mouseJournal of Neuroscience Methods, 167
(1982)
Gene transfer into the mouse germline
Neal Lemon, Selcen Aydın-Abidin, K. Funke, D. Manahan‐Vaughan (2009)
Locus Coeruleus Activation Facilitates Memory Encoding and Induces Hippocampal LTD that Depends on β-Adrenergic Receptor ActivationCerebral Cortex (New York, NY), 19
A. Heynen, W. Abraham, M. Bear (1996)
Bidirectional modification of CA1 synapses in the adult hippocampus in vivoNature, 381
A. Kemp, D. Manahan‐Vaughan (2004)
Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition.Proceedings of the National Academy of Sciences of the United States of America, 101 21
(2008)
long-term potentiation induction
S. Cooke, Jianqun Wu, F. Plattner, M. Errington, M. Rowan, M. Peters, A. Hirano, K. Bradshaw, R. Anwyl, T. Bliss, K. Giese (2006)
Autophosphorylation of αCaMKII is not a general requirement for NMDA receptor‐dependent LTP in the adult mouseThe Journal of Physiology, 574
Tao Zhang, Jianrong Tang, V. Pidoplichko, J. Dani (2010)
Addictive Nicotine Alters Local Circuit Inhibition during the Induction of In Vivo Hippocampal Synaptic PotentiationThe Journal of Neuroscience, 30
Matt Jones, H. Peckham, M. Errington, T. Bliss, A. Routtenberg (2001)
Synaptic plasticity in the hippocampus of awake C57BL/6 and DBA/2 mice: Interstrain differences and parallels with behaviorHippocampus, 11
D. Manahan‐Vaughan (1997)
Group 1 and 2 Metabotropic Glutamate Receptors Play Differential Roles in Hippocampal Long-Term Depression and Long-Term Potentiation in Freely Moving RatsThe Journal of Neuroscience, 17
G. Köhr, V. Jensen, H. Koester, André Mihaljevic, J. Utvik, A. Kvello, O. Ottersen, P. Seeburg, R. Sprengel, Ø. Hvalby (2003)
Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation InductionThe Journal of Neuroscience, 23
Sven Berberich, V. Jensen, Ø. Hvalby, P. Seeburg, G. Köhr (2007)
The role of NMDAR subtypes and charge transfer during hippocampal LTP inductionNeuropharmacology, 52
Sreedharan Sajikumar, Sheeja Navakkode, J. Frey (2008)
Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1.Learning & memory, 15 2
J. Bergado, S. Frey, Jeffrey López, W. Almaguer‐Melian, J. Frey (2007)
Cholinergic afferents to the locus coeruleus and noradrenergic afferents to the medial septum mediate LTP-reinforcement in the dentate gyrus by stimulation of the amygdalaNeurobiology of Learning and Memory, 88
Z. Bashir, Z. Bortolotto, C. Davies, N. Berretta, A. Irving, Andrew Seal, J. Henley, D. Jane, J. Watkins, G. Collingridge (1993)
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptorsNature, 363
F. Costantini, E. Lacy (1981)
Introduction of a rabbit β-globin gene into the mouse germ lineNature, 294
M. Bear (1996)
A synaptic basis for memory storage in the cerebral cortex.Proceedings of the National Academy of Sciences of the United States of America, 93 24
G. Collingridge (1987)
The role of NMDA receptors in learning and memoryNature, 330
(2002)
Expression of constitutively
(2007)
Differential effects
W. Abraham, B. Logan, J. Greenwood, M. Dragunow (2002)
Induction and Experience-Dependent Consolidation of Stable Long-Term Potentiation Lasting Months in the HippocampusThe Journal of Neuroscience, 22
K. Franklin, G. Paxinos (2001)
The Mouse Brain in Stereotaxic Coordinates
M. Er̀rington, T. Bliss, R. Morris, S. Laroche, S. Davis (1997)
Long-term potentiation in awake mutant miceNature, 387
S. Popkirov, D. Manahan‐Vaughan (2010)
Involvement of the Metabotropic Glutamate Receptor mGluR5 in NMDA Receptor-Dependent, Learning-Facilitated Long-Term Depression in CA1 SynapsesCerebral Cortex (New York, NY), 21
R. Mulkey, R. Malenka (1992)
Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampusNeuron, 9
S. Neyman, D. Manahan‐Vaughan (2008)
Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitroThe European Journal of Neuroscience, 27
B. Pöschel, D. Manahan‐Vaughan (2005)
Group II mGluR-induced long term depression in the dentate gyrus in vivo is NMDA receptor-independent and does not require protein synthesisNeuropharmacology, 49
(2004)
Involvement of cannabinoid CB 1 receptor in associative learning and in hippocampal CA 3 - CA 1 synaptic plastic
Hardy Hagena, D. Manahan‐Vaughan (2011)
Learning-Facilitated Synaptic Plasticity at CA3 Mossy Fiber and Commissural–Associational Synapses Reveals Different Roles in Information ProcessingCerebral Cortex (New York, NY), 21
Christopher Fox, Kyle Russell, Y. Wang, B. Christie (2006)
Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivoHippocampus, 16
A. Hendricson, C. Miao, M. Lippmann, R. Morrisett (2002)
Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression.The Journal of pharmacology and experimental therapeutics, 301 3
S. Davis, T. Bliss, G. Dutrieux, S. Laroche, M. Er̀rington (1997)
Induction and duration of long-term potentiation in the hippocampus of the freely moving mouseJournal of Neuroscience Methods, 75
(1986)
Synaptic plasticity and learning : Selective impairment of learning rats and blockade of long - term potentiation in vivo by the N - methyl - D - aspartate receptor antagonist AP 5
A. Kulla, K. Reymann, D. Manahan‐Vaughan (1999)
Time‐dependent induction of depotentiation in the dentate gyrus of freely moving rats: involvement of group 2 metabotropic glutamate receptorsEuropean Journal of Neuroscience, 11
Neal Lemon, D. Manahan‐Vaughan (2006)
Dopamine D1/D5 Receptors Gate the Acquisition of Novel Information through Hippocampal Long-Term Potentiation and Long-Term DepressionThe Journal of Neuroscience, 26
U. Frey, H. Schroeder, H. Matthies (1990)
Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slicesBrain Research, 522
R. Morris, Elizabeth Anderson, G. Lynch, M. Baudry (1986)
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5Nature, 319
J. Goh, D. Manahan‐Vaughan (2012)
Spatial Object Recognition Enables Endogenous LTD that Curtails LTP in the Mouse HippocampusCerebral Cortex (New York, NY), 23
S. Martin, P. Grimwood, R. Morris (2000)
Synaptic plasticity and memory: an evaluation of the hypothesis.Annual review of neuroscience, 23
A. Kulla, D. Manahan‐Vaughan (2000)
Depotentiation in the dentate gyrus of freely moving rats is modulated by D1/D5 dopamine receptors.Cerebral cortex, 10 6
A. Barco, J. Alarcon, E. Kandel (2002)
Expression of Constitutively Active CREB Protein Facilitates the Late Phase of Long-Term Potentiation by Enhancing Synaptic CaptureCell, 108
(1989)
Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo
I. Wilson, J. Puoliväli, T. Heikkinen, P. Riekkinen (1999)
Estrogen and NMDA receptor antagonism: effects upon reference and working memory.European journal of pharmacology, 381 2-3
F. Costantini, E. Lacy (1982)
Gene transfer into the mouse germ‐lineJournal of Cellular Physiology, 113
A. Milner, D. Cummings, J. Spencer, K. Murphy (2004)
Bi-directional plasticity and age-dependent long-term depression at mouse CA3-CA1 hippocampal synapsesNeuroscience Letters, 367
Yan-You Huang, P. Nguyen, T. Abel, E. Kandel (1996)
Long-lasting forms of synaptic potentiation in the mammalian hippocampus.Learning & memory, 3 2-3
Jianrong Tang, J. Dani (2009)
Dopamine Enables In Vivo Synaptic Plasticity Associated with the Addictive Drug NicotineNeuron, 63
(2004)
of awake C 57 BL / 6 and DBA / 2 mice : Interstrain differences and parallels with behav
A. Kemp, D. Manahan‐Vaughan (2008)
Beta-adrenoreceptors comprise a critical element in learning-facilitated long-term plasticity.Cerebral cortex, 18 6
K. Nakazawa, T. McHugh, M. Wilson, S. Tonegawa (2004)
NMDA receptors, place cells and hippocampal spatial memoryNature Reviews Neuroscience, 5
(2004)
Role of NMDA receptor subtypes
D. Manahan‐Vaughan, K. Braunewell (1999)
Novelty acquisition is associated with induction of hippocampal long-term depression.Proceedings of the National Academy of Sciences of the United States of America, 96 15
D. Manahan‐Vaughan (2000)
Long-term depression in freely moving rats is dependent upon strain variation, induction protocol and behavioral state.Cerebral cortex, 10 5
(2003)
Requirement of b-adrenergic receptor activation and protein synthesis for LTPreinforcement by novelty in rat dentate gyrus
J. Rick, N. Milgram (1999)
Instability of Dentate Gyrus Field Potentials in Awake and Anesthetized RatsHippocampus, 9
Á. Fontán-Lozano, J. Sáez-Cassanelli, Maria Inda, Mercedes Santos-Arteaga, S. Sierra-Domínguez, G. López-Lluch, J. Delgado-García, Á. Carrión (2007)
Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA ReceptorThe Journal of Neuroscience, 27
Hippocampal synaptic plasticity in the form of long‐term potentiation (LTP) and long‐term depression (LTD) is likely to enable synaptic information storage in support of memory formation. The mouse brain has been subjected to intensive scrutiny in this regard; however, a multitude of studies has examined synaptic plasticity in the hippocampal slice preparation, whereas very few have addressed synaptic plasticity in the freely behaving mouse. Almost nothing is known about the frequency or N‐methyl‐D‐aspartate receptor (NMDAR) dependency of hippocampal synaptic plasticity in the intact mouse brain. Therefore, in this study, we investigated the forms of synaptic plasticity that are elicited at different afferent stimulation frequencies. We also addressed the NMDAR dependency of this phenomenon. Adult male C57BL/6 mice were chronically implanted with a stimulating electrode into the Schaffer collaterals and a recording electrode into the Stratum radiatum of the CA1 region. To examine synaptic plasticity, we chose protocols that were previously shown to produce either LTP or LTD in the hippocampal slice preparation. Low‐frequency stimulation (LFS) at 1 Hz (900 pulses) had no effect on evoked responses. LFS at 3 Hz (ranging from 200 up to 2 × 900 pulses) elicited short‐term depression (STD, <45 min). LFS at 3 Hz (1,200 pulses) elicited slow‐onset potentiation, high‐frequency stimulation (HFS) at 100 Hz (100 or 200 pulses) or at 50 Hz was ineffective, whereas 100 Hz (50 pulses) elicited short‐term potentiation (STP). HFS at 100 Hz given as 2 × 30, 2 × 50, or 4 × 50 pulses elicited LTP (>24 h). Theta‐burst stimulation was ineffective. Antagonism of the NMDAR prevented STD, STP, and LTP. This study shows for the first time that protocols that effectively elicit persistent synaptic plasticity in the slice preparation elicit distinctly different effects in the intact mouse brain. Persistent LTD could not be elicited with any of the protocols tested. Plasticity responses are NMDAR dependent, suggesting that these phenomena are relevant for hippocampus‐dependent learning. © 2012 Wiley Periodicals, Inc.
Hippocampus – Wiley
Published: Dec 1, 2012
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