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Fitting of multifactor models to family data

Fitting of multifactor models to family data Fitting of multifactor models to family data BY S . R.WILSON Department of Probability and Statistics, the University, Shefield S 3 7RH INTRODUCTION Genetic hypotheses involving a large number of factors have been often applied t o data for normally distributed quantitative traits such as stature and intelligence. More recently they have been applied to intrafamilial data for characteristics which are apparently discontinuous, such as diabetes, cleft palate, schizophrenia and other mental disorders, in attempting to determine the mode of inheritance of such characteristics (Carter, 1969; Edwards, 1960, 1969; Falconer, 1965; Slater & Cowie, 1971; Smith, 1970). I n these analyses of data for all-or-none characteristics, under the assumption of random mating, varying approximate estimates of heritability (additive genetic variance as a proportion of phenotypic variance) have been usually determined for each group of relatives considered separately. But no direct method of determining first whether the data are compatible with the multifactorial hypothesis has been given. So in section 1, the general multifactorial model for the inheritance of a discontinuous trait is reformulated (incorporating assortative mating) and the theoretical frequencies in relatives of propositi are determined. Then, given the observed frequencies in relatives, the general method of estimating http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Fitting of multifactor models to family data

WILSON, S. R.
Annals of Human Genetics , Volume 38 (2) – Oct 1, 1974
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References (30)

Publisher
Wiley
Copyright
Copyright © 1974 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1974.tb01953.x
Publisher site
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Abstract

Fitting of multifactor models to family data BY S . R.WILSON Department of Probability and Statistics, the University, Shefield S 3 7RH INTRODUCTION Genetic hypotheses involving a large number of factors have been often applied t o data for normally distributed quantitative traits such as stature and intelligence. More recently they have been applied to intrafamilial data for characteristics which are apparently discontinuous, such as diabetes, cleft palate, schizophrenia and other mental disorders, in attempting to determine the mode of inheritance of such characteristics (Carter, 1969; Edwards, 1960, 1969; Falconer, 1965; Slater & Cowie, 1971; Smith, 1970). I n these analyses of data for all-or-none characteristics, under the assumption of random mating, varying approximate estimates of heritability (additive genetic variance as a proportion of phenotypic variance) have been usually determined for each group of relatives considered separately. But no direct method of determining first whether the data are compatible with the multifactorial hypothesis has been given. So in section 1, the general multifactorial model for the inheritance of a discontinuous trait is reformulated (incorporating assortative mating) and the theoretical frequencies in relatives of propositi are determined. Then, given the observed frequencies in relatives, the general method of estimating

Journal

Annals of Human Genetics – Wiley

Published: Oct 1, 1974

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