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E. Slater (1958)
The monogenic theory of schizophrenia.Acta genetica et statistica medica, 8 1
(1968)
The Transmimion of Schizophrenia
E. ESSEN-MOLLER (1955)
The calculation of morbid risk in parents of index cases, as applied to a family sample of schizophrenics.Acta genetica et statistica medica, 5 4
(1967)
Endogene Psychosen
Fitting of models of incomplete penetrance to family data BY S . R. WILSON Department of Statistics, Institute of Advanced Studies, Australian National University, Canberra This is the first of a series of papers on determining the mode of inheritance of a disease when the population incidence and familial incidences of propositi are known. In the simply inherited disorders in which some factor is necessary and sufficient for the manifestation of the disease as in the dominant and recessive conditions that have been clearly distinguished in man, the pattern of inheritance has in many cases been discovered through, and in all situations substantiated by, the statistical analysis of familial incidences and the model relevant to the particular situation has been shown to âfitâ the given observations. When the simple one-to-one map between abnormal genes and abnormal phenotypes cannot be applied, the fitting of a genetic hypothesis concerning the mode of inheritance to familial data becomes substantially more difficult. Hence the situation arises that for a large number of diseases, many theories involving one, two up to an infinite number of factors, have been put forward and substantiated by the relevant data, some to a better degree than others.
Annals of Human Genetics – Wiley
Published: Jul 1, 1971
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