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Family studies with the chromosome 9 markers ABO, AK 1 , ACON s and 9qh

Family studies with the chromosome 9 markers ABO, AK 1 , ACON s and 9qh BY E. B. ROBSON, P. J. L. COOK M.R.C. Human Biochemical Genetics Unit, The Galton Laboratory, University College London AND K. E. BUCKTON M.R.C. Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh The ABO blood group locus ( A B O ) was shown to be linked to that for the Nail-patella syndrome ( N p )by Renwick & Lawler in 1955. No additions were made to this linkage group until 1967 when Rapley et aZ. demonstrated linkage between A B O and the locus determining the polymorphism of the red cell enzyme adenylate kinase (AK,). Both of these claims have been confirmed by further work by these and other authors. N p must be very close to A K , because no recombinants have been observed out of 61 reported opportunities (Sobel, Tiger & Gerald, 1971; Schleutermann et al. 1969). Since 1974 several laboratories have assigned A K , to chromosome 9 by the use of humanrodent somatic cell hybrids (Westerveld et al. 1976; Povey, et al. 1976; Grzeschik, 1976; Nguyen Van Cong et al. 1976).There is also evidence from hybrid studies that another adenylate kinase locus (AK,),and the locus for soluble aconitase (ACON,) may also http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Family studies with the chromosome 9 markers ABO, AK 1 , ACON s and 9qh

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References (39)

Publisher
Wiley
Copyright
Copyright © 1977 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1977.tb01961.x
Publisher site
See Article on Publisher Site

Abstract

BY E. B. ROBSON, P. J. L. COOK M.R.C. Human Biochemical Genetics Unit, The Galton Laboratory, University College London AND K. E. BUCKTON M.R.C. Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh The ABO blood group locus ( A B O ) was shown to be linked to that for the Nail-patella syndrome ( N p )by Renwick & Lawler in 1955. No additions were made to this linkage group until 1967 when Rapley et aZ. demonstrated linkage between A B O and the locus determining the polymorphism of the red cell enzyme adenylate kinase (AK,). Both of these claims have been confirmed by further work by these and other authors. N p must be very close to A K , because no recombinants have been observed out of 61 reported opportunities (Sobel, Tiger & Gerald, 1971; Schleutermann et al. 1969). Since 1974 several laboratories have assigned A K , to chromosome 9 by the use of humanrodent somatic cell hybrids (Westerveld et al. 1976; Povey, et al. 1976; Grzeschik, 1976; Nguyen Van Cong et al. 1976).There is also evidence from hybrid studies that another adenylate kinase locus (AK,),and the locus for soluble aconitase (ACON,) may also

Journal

Annals of Human Genetics – Wiley

Published: Jul 1, 1977

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