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Family studies on nucleoside phosphorylase and the short arm of chromosome 14

Family studies on nucleoside phosphorylase and the short arm of chromosome 14 SUMMARY A family with two nucleoside phosphorylase‐deficient patients has been scored for the segregation of NP0 and the variable region 14p. The most likely 14p: NP recombination fraction is (M5 in males and 0–30 in females. There is no family data to assign the Pi:Gm linkage group to chromosome 14, but as immunoglobulin heavy chain has been assigned to this chromosome by somatic cell methods the most likely gene order is 14p:NP: Pi:Gm with Pi in 14q2 and Gm in 14(q23 →q32), but the order 14p:NP:Gm:Pi with Pi in 14(q24 → qter) and Gm in 14(q22 → q24) is not excluded. The available linkage data between biochemical markers on acrocentric chromosomes and their short arm markers suggest that there may be more recombination towards the ends of human chromosomes whether or not those ends carry centromeres. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Family studies on nucleoside phosphorylase and the short arm of chromosome 14

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References (30)

Publisher
Wiley
Copyright
Copyright © 1981 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1981.tb00336.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY A family with two nucleoside phosphorylase‐deficient patients has been scored for the segregation of NP0 and the variable region 14p. The most likely 14p: NP recombination fraction is (M5 in males and 0–30 in females. There is no family data to assign the Pi:Gm linkage group to chromosome 14, but as immunoglobulin heavy chain has been assigned to this chromosome by somatic cell methods the most likely gene order is 14p:NP: Pi:Gm with Pi in 14q2 and Gm in 14(q23 →q32), but the order 14p:NP:Gm:Pi with Pi in 14(q24 → qter) and Gm in 14(q22 → q24) is not excluded. The available linkage data between biochemical markers on acrocentric chromosomes and their short arm markers suggest that there may be more recombination towards the ends of human chromosomes whether or not those ends carry centromeres.

Journal

Annals of Human GeneticsWiley

Published: Jul 1, 1981

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