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Familial transmission of a translocation between two non‐homologous large acrocentric chromosomes. Clinical, cytogenetic and autoradiographic studies

Familial transmission of a translocation between two non‐homologous large acrocentric... BY PETREA JACOBSEN,* MARGARETA MIKKELSEN,? A. FR0LANDf AND ANNALISE DUPONT* * Institute for Mental Defectives for South-East Jutland, Brejning, Denmark, and t University Institute for Medical Genetics, Copenhagen, Denmark INTRODUCTION Penrose, Ellis & Delhanty ( 1960) demonstrated for the first time that reciprocal translocations may occur in a balanced form in man and may segregate through several generations. Since then, various types of familial reciprocal translocations have been described in which at least one chromosome of the 13-15 group has been involved (Brodie & Dallaire, 1962; Vislie, Wehn, Brprgger & Mohr, 1962; Migeon & Young, 1964; Stalder et al. 1964). Walker & Harris (1962) described a family with a translocation between two chromosomes in the 13-15 group. The abnormal chromosome was transmitted through three generations. Familial translocations of the same type were described by Pitt, Ferguson & Baikie, 19134; Grouchy, Mlynarski et al. 1963; Hamerton, Giannelli & Carter, 1963; Zergollern, Hoefnagel, Benirschke & Corcoran, 1964; and Yunis, Alter, Hook & Mayer, 1964. A similar type of famillial chromosome abnormality described was by Jagiello (1963). A new type of translocation between two chromosomes of the 13-15 group has been observed by the present authors. A preliminary report was published http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Familial transmission of a translocation between two non‐homologous large acrocentric chromosomes. Clinical, cytogenetic and autoradiographic studies

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References (36)

Publisher
Wiley
Copyright
Copyright © 1966 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1966.tb00537.x
Publisher site
See Article on Publisher Site

Abstract

BY PETREA JACOBSEN,* MARGARETA MIKKELSEN,? A. FR0LANDf AND ANNALISE DUPONT* * Institute for Mental Defectives for South-East Jutland, Brejning, Denmark, and t University Institute for Medical Genetics, Copenhagen, Denmark INTRODUCTION Penrose, Ellis & Delhanty ( 1960) demonstrated for the first time that reciprocal translocations may occur in a balanced form in man and may segregate through several generations. Since then, various types of familial reciprocal translocations have been described in which at least one chromosome of the 13-15 group has been involved (Brodie & Dallaire, 1962; Vislie, Wehn, Brprgger & Mohr, 1962; Migeon & Young, 1964; Stalder et al. 1964). Walker & Harris (1962) described a family with a translocation between two chromosomes in the 13-15 group. The abnormal chromosome was transmitted through three generations. Familial translocations of the same type were described by Pitt, Ferguson & Baikie, 19134; Grouchy, Mlynarski et al. 1963; Hamerton, Giannelli & Carter, 1963; Zergollern, Hoefnagel, Benirschke & Corcoran, 1964; and Yunis, Alter, Hook & Mayer, 1964. A similar type of famillial chromosome abnormality described was by Jagiello (1963). A new type of translocation between two chromosomes of the 13-15 group has been observed by the present authors. A preliminary report was published

Journal

Annals of Human GeneticsWiley

Published: May 1, 1966

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