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K. Wickens, J. Lane, P. Fitzharris, R. Siebers, G. Riley, J. Douwes, J. Douwes, T. Smith, Julian Crane (2002)
Farm residence and exposures and the risk of allergic diseases in New Zealand childrenAllergy, 57
J. Douwes, S. Cheng, N. Travier, C. Cohet, A. Niesink, J. Mckenzie, C. Cunningham, G. Gros, E. Mutius, N. Pearce (2008)
Farm exposure in utero may protect against asthma, hay fever and eczemaEuropean Respiratory Journal, 32
M. Perkin, D. Strachan (2006)
Which aspects of the farming lifestyle explain the inverse association with childhood allergy?The Journal of allergy and clinical immunology, 117 6
S. Downs, G. Marks, T. Mitakakis, J. Leuppi, N. Car, J. Peat (2001)
Having lived on a farm and protection against allergic diseases in AustraliaClinical & Experimental Allergy, 31
N. Åberg (1989)
Asthma and allergic rhinitis in Swedish conscriptsClinical & Experimental Allergy, 19
M. Ege, D. Strachan, W. Cookson, M. Moffatt, I. Gut, M. Lathrop, M. Kabesch, J. Genuneit, G. Büchele, B. Sozańska, A. Boznański, P. Cullinan, E. Horak, C. Bieli, C. Braun‐Fahrländer, D. Heederik, E. Mutius (2011)
Gene-environment interaction for childhood asthma and exposure to farming in Central Europe.The Journal of allergy and clinical immunology, 127 1
Sami Remes, Juha Pekkanen, L. Soininen, M. Kajosaari, T. Husman, A. Koivikko (2002)
Does heredity modify the association between farming and allergy in children?Acta Pædiatrica, 91
J. Riedler, C. Braun‐Fahrländer, W. Eder, M. Schreuer, M. Waser, S. Maisch, D. Carr, R. Schierl, D. Nowak, E. Mutius (2001)
Exposure to farming in early life and development of asthma and allergy: a cross-sectional surveyThe Lancet, 358
L. Bråbäck, A. Hjern, F. Rasmussen (2004)
Trends in asthma, allergic rhinitis and eczema among Swedish conscripts from farming and non‐farming environments. A nationwide study over three decadesClinical & Experimental Allergy, 34
J. Hoppin, D. Umbach, S. London, P. Henneberger, G. Kullman, M. Alavanja, D. Sandler (2008)
Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.American journal of respiratory and critical care medicine, 177 1
J. Stockman (2012)
Exposure to Environmental Microorganisms and Childhood AsthmaYearbook of Pediatrics, 2012
J. Sterne, M. Egger, G. Smith (2001)
Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis.BMJ, 323 7304
U. Kiechl-Kohlendorfer, E. Horak, W. Mueller, R. Strobl, C. Haberland, F. Fink, M. Schwaiger, K. Gutenberger, H. Reich, D. Meraner, S. Kiechl (2007)
Neonatal characteristics and risk of atopic asthma in schoolchildren: results from a large prospective birth‐cohort studyActa Pædiatrica, 96
A. Schulze, R. Strien, G. Praml, D. Nowak, Katja Radon (2007)
Characterisation of asthma among adults with and without childhood farm contactEuropean Respiratory Journal, 29
C. Johnson, S. Alford (2002)
Do animals on the farm and in the home reduce the risk of pediatric atopy?Current Opinion in Allergy and Clinical Immunology, 2
W. Eder, M. Ege, E. Mutius (2006)
The asthma epidemic.The New England journal of medicine, 355 21
E. Mutius (2000)
The environmental predictors of allergic disease.The Journal of allergy and clinical immunology, 105 1 Pt 1
M. Egger, G. Smith, Martin Schneider, C. Minder (1997)
Bias in meta-analysis detected by a simple, graphical testBMJ, 315
E. Mutius, D. Vercelli (2010)
Farm living: effects on childhood asthma and allergyNature Reviews Immunology, 10
P. Burney, C. Luczynska, S. Chinn, D. Jarvis (1994)
The European Community Respiratory Health Survey IIEuropean Respiratory Journal, 21
J. Lampi, D. Canoy, D. Jarvis, A. Hartikainen, L. Keski-Nisula, M. Järvelin, J. Pekkanen (2011)
Farming environment and prevalence of atopy at age 31: prospective birth cohort study in FinlandClinical & Experimental Allergy, 41
Pierre Ernst, Y. Cormier (2000)
Relative scarcity of asthma and atopy among rural adolescents raised on a farm.American journal of respiratory and critical care medicine, 161 5
Jeroen Douwes, Noémie Travier, K. Huang, K. Huang, Soo Cheng, Joanna McKenzie, G. Gros, E. Mutius, Neil Pearce (2007)
Lifelong farm exposure may strongly reduce the risk of asthma in adultsAllergy, 62
J. Lawson, D. Rennie, A. Senthilselvan, H. McDuffie, D. Cockcroft (2007)
Occurrence of new-onset wheeze in a 3-year follow-up study of schoolchildren.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 99 6
H. Dimich‐Ward, Yat Chow, J. Chung, Catherine Trask (2006)
Contact with livestock – a protective effect against allergies and asthma?Clinical & Experimental Allergy, 36
C. Zekveld, I. Bibakis, V. Bibaki-Liakou, A. Pedioti, I. Dimitroulis, Jessica Harris, A. Taylor, P. Cullinan (2006)
The effects of farming and birth order on asthma and allergiesEuropean Respiratory Journal, 28
E. Mutius, K. Radon (2008)
Living on a farm: impact on asthma induction and clinical course.Immunology and allergy clinics of North America, 28 3
W. Midodzi, B. Rowe, C. Majaesic, A. Senthilselvan (2007)
Reduced risk of physician‐diagnosed asthma among children dwelling in a farming environmentRespirology, 12
M. Ege, R. Frei, C. Bieli, D. Schram-Bijkerk, M. Waser, M. Benz, Gertraud Weiss, F. Nyberg, M. Hage, G. Pershagen, B. Brunekreef, J. Riedler, R. Lauener, C. Braun‐Fahrländer, E. Mutius (2007)
Not all farming environments protect against the development of asthma and wheeze in children.The Journal of allergy and clinical immunology, 119 5
A. Naleway (2004)
Asthma and atopy in rural children: is farming protective?Clinical medicine & research, 2 1
Ø. Omland, C. Hjort, O. Pedersen, Martin Miller, T. Sigsgaard (2011)
New-onset asthma and the effect of environment and occupation among farming and nonfarming rural subjects.The Journal of allergy and clinical immunology, 128 4
S. Sigurdarson, J. Kline (2006)
School proximity to concentrated animal feeding operations and prevalence of asthma in students.Chest, 129 6
Kevin Tse, A. Horner (2008)
Defining a role for ambient TLR ligand exposures in the genesis and prevention of allergic diseasesSeminars in Immunopathology, 30
W. Molis, S. Bagniewski, A. Weaver, R. Jacobson, Y. Juhn (2008)
Timeliness of diagnosis of asthma in children and its predictorsAllergy, 63
E. Mutius (2007)
Asthma and allergies in rural areas of Europe.Proceedings of the American Thoracic Society, 4 3
S. Chinn, C. Luczynska, D. Jarvis, E. Khaled, Austria Popp, J. Abramson, F. Vermeire, M. Dahl, Estonia Jögi, F. Neukirch, R. Liard, I. Pin, C. Teculescu, J. Wichmann, Greece Papageorgiou, P. Avarlis, M. Gaga, C. Marossis, Iceland Gislason, India Chowgule, Ireland Prichard, S. Allwright, D. Macleod, C. Bucca, C. Romano, R. Marco, V. Cascio, C. Campello, A. Marinoni, I. Cerveri, L. Casali, S. Crane, E. Gulsvik, Portugal Avila, R. Marques, C. Loureiro, C. Chieira, R. Cordeiro, J. Marques, J. Alves, Spain Anto, J. Castellsagué, J. Sunyer, J. Soriano, M. Roca, N. Muniozguren, J. González, A. Capelastegui, J. Castillo, E. Almar, J. Pereira, J. Sánchez, J. Quirós, I. Huerta, Sweden Boman, C. Janson, E. Björnsson, L. Rosenhall, E. Norrman, B. Lundbäck, N. Lindholm, P. Plaschke, Switzerland Liebrich, N. Künzli, A. Perruchoud, United Burr, J. Layzell, R. Hall, B. Harrison, J. Stark, C. Florey, A. Pereira, R. Clark, Usa Buist, W. Vollmer, M. Osborne (1996)
Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS).The European respiratory journal, 9 4
L. Portengen, T. Sigsgaard, Ø. Omland, C. Hjort, D. Heederik, G. Doekes (2002)
Low prevalence of atopy in young Danish farmers and farming students born and raised on a farmClinical & Experimental Allergy, 32
C. Braun‐Fahrländer (2001)
The role of the farm environment and animal contact for the development of asthma and allergiesClinical & Experimental Allergy, 31
P. Ellwood, Hywel Williams, N. Aït-Khaled, Bengt Björkstén, Colin Robertson (2009)
Translation of questions: the International Study of Asthma and Allergies in Childhood (ISAAC) experience.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 13 9
Ege (2011)
Exposure to environmental microorganisms and childhood asthmaN Engl J Med, 364
M. Masley, K. Semchuk, A. Senthilselvan, H. McDuffie, P. Hanke, J. Dosman, A. Cessna, M. Crossley, D. Irvine, A. Rosenberg, L. Hagel (2000)
Health and environment of rural families: results of a Community Canvass survey in the Prairie Ecosystem Study (PECOS).Journal of agricultural safety and health, 6 2
O. Ehrenstein, E. Mutius, S. Illi, L. Baumann, O. Böhm, R. Kries (2000)
Reduced risk of hay fever and asthma among children of farmersClinical & Experimental Allergy, 30
Lewis (2000)
Animals and allergyClinical & Experimental Allergy, 30
J. Genuneit, G. Büchele, M. Waser, K. Kovács, A. Dębińska, A. Boznański, C. Strunz-Lehner, E. Horak, P. Cullinan, D. Heederik, C. Braun‐Fahrländer, E. Mutius (2011)
The GABRIEL Advanced Surveys: study design, participation and evaluation of bias.Paediatric and perinatal epidemiology, 25 5
G. Wennergren, L. Ekerljung, B. Alm, J. Eriksson, J. Lötvall, B. Lundbäck (2010)
Asthma in late adolescence – farm childhood is protective and the prevalence increase has levelled offPediatric Allergy and Immunology, 21
J. Higgins, S. Thompson (2002)
Quantifying heterogeneity in a meta‐analysisStatistics in Medicine, 21
P. Burney, C. Luczynska, S. Chinn, D. Jarvis (1994)
The European Community Respiratory Health Survey.The European respiratory journal, 7 5
Farm - ing environments and childhood atopy , wheeze , lung function , and exhaled nitric oxide
Wong (2008)
Childhood asthma epidemiology: insights from comparative studies of rural and urban populationsPediatr Pulmonol, 43
Asher, Weiland (1998)
The International Study of Asthma and Allergies in Childhood (ISAAC)Clinical & Experimental Allergy, 28
M. Asher, U. Keil, H. Anderson, R. Beasley, J. Crane, F. Martinez, E. Mitchell, N. Pearce, B. Sibbald, A. Stewart, D. Strachan, S. Weiland, H. Williams (1995)
International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods.The European respiratory journal, 8 3
B. Klintberg, N. Berglund, G. Lilja, M. Wickman, M. Hage‐Hamsten (2001)
Fewer allergic respiratory disorders among farmers' children in a closed birth cohort from Sweden.The European respiratory journal, 17 6
M. Gassner-Bachmann, B. Wüthrich (2000)
[Farmers' children suffer less from hay fever and asthma].Deutsche medizinische Wochenschrift, 125 31-32
A. Adler, I. Tager, D. Quintero (2005)
Decreased prevalence of asthma among farm-reared children compared with those who are rural but not farm-reared.The Journal of allergy and clinical immunology, 115 1
Josef Riedler, W. Eder, G. Oberfeld, M. Schreuer (2000)
Austrian children living on a farm have less hay fever, asthma and allergic sensitizationClinical & Experimental Allergy, 30
B. Leynaert, C. Neukirch, D. Jarvis, S. Chinn, P. Burney, F. Neukirch (2001)
Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood?American journal of respiratory and critical care medicine, 164 10 Pt 1
Varraso (2011)
Farming in childhood, diet in adulthood and asthma history [Internet]Eur Respir J
C. Braun‐Fahrländer, M. Gassner, L. Grize, U. Neu, F. Sennhauser, H. Varonier, J. Vuille, B. Wüthrich (1999)
Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural communityClinical & Experimental Allergy, 29
J. Merchant, A. Naleway, E. Svendsen, K. Kelly, L. Burmeister, A. Stromquist, C. Taylor, P. Thorne, S. Reynolds, W. Sanderson, E. Chrischilles (2004)
Asthma and Farm Exposures in a Cohort of Rural Iowa ChildrenEnvironmental Health Perspectives, 113
T. Alfvén, C. Braun‐Fahrländer, B. Brunekreef, E. Mutius, J. Riedler, A. Scheynius, M. Hage, M. Wickman, M. Benz, J. Budde, K. Michels, D. Schram, E. Üblagger, M. Waser, G. Pershagen (2006)
Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle – the PARSIFAL studyAllergy, 61
S. Remes, H. Koskela, K. Iivanainen, J. Pekkanen (2005)
Allergen‐specific sensitization in asthma and allergic diseases in children: the study on farmers' and non‐farmers' childrenClinical & Experimental Allergy, 35
K. Yeatts, K. Davis, M. Sotir, C. Herget, C. Shy (2003)
Who gets diagnosed with asthma? Frequent wheeze among adolescents with and without a diagnosis of asthma.Pediatrics, 111 5 Pt 1
D. Rennie, J. Dosman (1999)
Distance to Health Care and the Prevalence of Asthma in School Age ChildrenJournal of agricultural safety and health, 5
M. Kilpeläinen, E. Terho, H. Helenius, M. Koskenvuo (2000)
Farm environment in childhood prevents the development of allergiesClinical & Experimental Allergy, 30
G. Loss, Silvia Apprich, M. Waser, W. Kneifel, J. Genuneit, G. Büchele, J. Weber, B. Sozańska, H. Danielewicz, E. Horak, R. Neerven, D. Heederik, Peter Lorenzen, E. Mutius, C. Braun‐Fahrländer (2011)
The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study.The Journal of allergy and clinical immunology, 128 4
R. Varraso, M. Oryszczyn, N. Mathieu, N. Moual, M. Boutron‐Ruault, F. Chapelon, I. Romieu, F. Kauffmann (2011)
Farming in childhood, diet in adulthood and asthma historyEuropean Respiratory Journal, 39
W. Brunner, P. Lindgren, D. Langner, Allan Williams, B. Yawn (2005)
Asthma Among Rural Minnesota AdolescentsJournal of Asthma, 42
L. Smit, M. Zuurbier, G. Doekes, I. Wouters, D. Heederik, J. Douwes (2006)
Hay fever and asthma symptoms in conventional and organic farmers in The NetherlandsOccupational and Environmental Medicine, 64
Osef, Iedler, Altraud, Der, Eticia, Rize, Oyoun, Aisch, Lorian, Erlach, Arald, Enz, Rika Von, Utius
ENVIRONMENTAL EXPOSURE TO ENDOTOXIN AND ITS RELATION TO ASTHMA IN SCHOOL-AGE CHILDREN
B. Leynaert, M. Guilloud‐Bataille, D. Soussan, J. Bénessiano, Armelle Guénégou, I. Pin, F. Neukirch (2006)
Association between farm exposure and atopy, according to the CD14 C-159T polymorphism.The Journal of allergy and clinical immunology, 118 3
S. Chai, N. Nga, H. Checkoway, T. Takaro, G. Redding, M. Keifer, L. Trung, S. Barnhart (2004)
Comparison of local risk factors for children's atopic symptoms in Hanoi, VietnamAllergy, 59
G. Wong, C. Chow (2007)
State of the Art Series : Global Pediatric Pulmonary Issues Childhood Asthma Epidemiology : Insights From Comparative Studies of Rural and Urban Populations
E. Chrischilles, R. Ahrens, A. Kuehl, K. Kelly, P. Thorne, L. Burmeister, J. Merchant (2004)
Asthma prevalence and morbidity among rural Iowa schoolchildren.The Journal of allergy and clinical immunology, 113 1
L. Smit, D. Heederik, G. Doekes, C. Blom, I. Zweden, I. Wouters (2008)
Exposure–response analysis of allergy and respiratory symptoms in endotoxin-exposed adultsEuropean Respiratory Journal, 31
To cite this article: Genuneit J. Exposure to farming environments in childhood and asthma and wheeze in rural populations: a systematic review with meta‐analysis. Pediatr Allergy Immunol 2012: 23: 509–518. Asthma is a chronic respiratory disorder that has become substantially more common over the past decades. One environmental factor for which particularly strong associations with asthma and allergic diseases have been described is exposure to farming environments in childhood. The aim of this systematic review was to update and extend existing narrative reviews, test for heterogeneity of effect across studies, and conduct a meta‐analysis to report a summary effect measure. Published relevant literature was searched through PubMed including all articles added to PubMed before September 1, 2011. Articles were included if they reported an epidemiological study on the exposure to a farming environment in childhood and subsequent wheeze or asthma. Heterogeneity of effect measures across studies was evaluated using Cochran’s Q and I2. Random‐effects meta‐analysis was performed to summarize effect measures for various outcome definitions. In total, 357 retrieved abstracts revealed 52 original articles from 39 studies with data considered for the meta‐analysis. Most studies were conducted among children or on childhood onset of disease. Most data were published on doctor‐diagnosed asthma or current wheeze. The meta‐analysis showed substantial heterogeneity across studies with similar outcome definitions. Nonetheless, the combined effects were statistically significant and showed an approximate 25% lower asthma prevalence among exposed subjects compared with unexposed subjects. The protective ‘farm‐effect’ on asthma was reported in numerous studies. Its underlying factors ought to be studied, and promising efforts have been already made. However, the heterogeneity of the effect across studies should also be investigated because whatever causes it is a potential threat to valid synthesis of evidence and to the detection of specific protective factors.
Pediatric Allergy and Immunology – Wiley
Published: Sep 1, 2012
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