Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/exploration-of-triple-helical-fragments-crystallization-and-jTwUmTPTbt
References (12)
-
L. Meervelt, D. Vlieghe, A. Dautant, B. Gallois, G. Précigoux, T. Singh (1995)
High-resolution structure of a DNA helix forming (C·G)*G base tripletsNature, 374
-
(2001)
Bioorg -
(1996)
Acta Cryst -
L. Griffin, L. Kiessling, P. Beal, Paul Gillespie, P. Dervan (1992)
Recognition of all four base pairs of double-helical DNA by triple-helix formation: design of nonnatural deoxyribonucleosides for pyrimidine•purine base pair bindingJournal of the American Chemical Society, 114
-
S. Gryaznov (1999)
Oligonucleotide N3'-->P5' phosphoramidates as potential therapeutic agents.Biochimica et biophysica acta, 1489 1
-
K. Hecke, P. Nam, Minh Nguyen, L. Meervelt (2005)
Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculationsThe FEBS Journal, 272
-
R. Gottlob, R. May (1986)
Methods and Results -
(1995)
Nature (London), 374, 742–744 -
K. Uytterhoeven, J. Šponer, L. Meervelt (2002)
Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG).European journal of biochemistry, 269 12
-
(1992)
Jnt CCP 4 / ESF – EACBM Newsl -
D. Vlieghe, J. Šponer, L. Meervelt (1999)
Crystal structure of d(GGCCAATTGG) complexed with DAPI reveals novel binding mode.Biochemistry, 38 50
-
D. Vlieghe, L. Meervelt, A. Dautant, B. Gallois, G. Précigoux, T. Singh (1996)
Parallel and Antiparallel (G·GC)2 Triple Helix Fragments in a Crystal StructureScience, 273
- Publisher
- Wiley
- Copyright
- Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1744-3091
- eISSN
- 1744-3091
- DOI
- 10.1107/S1744309106054522
- pmid
- 17183175
- Publisher site
- See Article on Publisher Site
Abstract
The nonamer d(GCGAATTCG) and decamer d(GGCCAATTGG), containing one and two overhanging guanines, respectively, form G·GC triplets in their crystal packing. In order to introduce a third subsequent T·AT triplet, the decamer was further extended by one overhanging thymine residue. Two different crystal morphologies of the sequence d(TGGCCTTAAGG) were obtained by hanging‐drop vapour diffusion and diffracted to 2.5 and 2.3 Å resolution, respectively. However, both crystals belong to the orthorhombic space group P212121, with similar unit‐cell parameters. Therefore, the two data sets could be merged to a resolution of 2.4 Å with unit‐cell parameters a = 26.97, b = 41.12, c = 52.72 Å.
Journal
Acta Crystallographica Section F – Wiley
Published: Jan 1, 2007