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Experimental xenotransplantation: a personal history *

Experimental xenotransplantation: a personal history * In 1963, I left the Scripps Clinic and Research Foundation in La Jolla, California, to assume the position of Assistant Professor of Surgery and Director of Surgical Research at the University of California in San Francisco (UCSF). In addition, it was my clinical challenge to establish a renal transplantation program at UCSF. In the research laboratory, I continued my studies on delayed‐type hypersensitivity and on the role of antibodies in homograft (allograft) 1 rejection. I was particularly intrigued by Keith Reemtsma's 1964 report of transplanting a series of chimpanzee kidneys into humans; with standard immunosuppression, one of those kidneys functioned well for 9 months, without evidence of rejection [ 1 ]. Heterotransplantation in discordant species Dating back to the early 1900s, many organ hetero (xenotransplants) from animals into humans had been attempted [ 2–8 ]. All were unsuccessful until Reemtsma's series, which gave new impetus to research into the immunologic mechanisms involved in heterotransplantation. My first post doctoral fellow, Robert J. Perper ( Fig. 1 ), was interested in obtaining a PhD in immunology; I assigned him the project of studying experimental renal heterotransplantation. His first series of experiments examined heterotransplantation of widely divergent species, crosstransplanting the kidneys http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Experimental xenotransplantation: a personal history *

Najarian, John S.
Xenotransplantation , Volume 10 (1) – Jan 1, 2003
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References (33)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1034/j.1399-3089.2003.01082.x
Publisher site
See Article on Publisher Site

Abstract

In 1963, I left the Scripps Clinic and Research Foundation in La Jolla, California, to assume the position of Assistant Professor of Surgery and Director of Surgical Research at the University of California in San Francisco (UCSF). In addition, it was my clinical challenge to establish a renal transplantation program at UCSF. In the research laboratory, I continued my studies on delayed‐type hypersensitivity and on the role of antibodies in homograft (allograft) 1 rejection. I was particularly intrigued by Keith Reemtsma's 1964 report of transplanting a series of chimpanzee kidneys into humans; with standard immunosuppression, one of those kidneys functioned well for 9 months, without evidence of rejection [ 1 ]. Heterotransplantation in discordant species Dating back to the early 1900s, many organ hetero (xenotransplants) from animals into humans had been attempted [ 2–8 ]. All were unsuccessful until Reemtsma's series, which gave new impetus to research into the immunologic mechanisms involved in heterotransplantation. My first post doctoral fellow, Robert J. Perper ( Fig. 1 ), was interested in obtaining a PhD in immunology; I assigned him the project of studying experimental renal heterotransplantation. His first series of experiments examined heterotransplantation of widely divergent species, crosstransplanting the kidneys

Journal

Xenotransplantation – Wiley

Published: Jan 1, 2003

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