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Executive function and functional and structural brain differences in middle‐age adults with autism spectrum disorder

Executive function and functional and structural brain differences in middle‐age adults with... AbbreviationsACCanterior cingulate cortexASDautism spectrum disorderCSTCcortico‐striatal‐thalamic‐corticalDMNdefault mode networkDTIdiffusion tensor imagingEFTEmbedded Figures TaskFAfractional anisotropyfMRIfunctional magnetic resonance imagingICAindependent component analysisMDmean diffusivitymPFCmedial prefrontal cortexNTneurotypicalRAVLTRey Auditory Verbal Learning TestROIregion of interestSNsalience networkSPM8Statistical Parametric Mapping 8SRS‐2Social Responsiveness Scale‐2TIVtotal intracranial volumeWCSTWisconsin Card Sorting TaskWMNworking memory network.IntroductionIt is understood that cognitive abilities change as a function of age, and many abilities decline as adults enter the middle‐age and elderly years. However, the impact of aging on the cognitive abilities of those with the developmental disorder autism spectrum disorder (ASD) is largely unknown. As the first children diagnosed with ASD are now elderly, this field of study is particularly important to the growing cohort of adults with ASD. Recent research confirmed that elderly adults with ASD, or the broader autism phenotype, report more cognitive problems than age‐matched neurotypical (NT) adults and continue to experience a low quality of life [van Heijst & Geurts, ; Wallace, Budgett, & Charlton, ]. Consequently, there is a need to further characterize cognitive and brain aging with ASD in order to inform optimal treatment and care.Aging may be particularly concerning for adults with ASD. While social communication deficits and restricted, repetitive behaviors and interest are essential, core symptoms of ASD, cognitive difficulties such http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

Executive function and functional and structural brain differences in middle‐age adults with autism spectrum disorder

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References (98)

Publisher
Wiley
Copyright
© 2017 International Society for Autism Research, Wiley Periodicals, Inc.
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.1842
pmid
28940848
Publisher site
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Abstract

AbbreviationsACCanterior cingulate cortexASDautism spectrum disorderCSTCcortico‐striatal‐thalamic‐corticalDMNdefault mode networkDTIdiffusion tensor imagingEFTEmbedded Figures TaskFAfractional anisotropyfMRIfunctional magnetic resonance imagingICAindependent component analysisMDmean diffusivitymPFCmedial prefrontal cortexNTneurotypicalRAVLTRey Auditory Verbal Learning TestROIregion of interestSNsalience networkSPM8Statistical Parametric Mapping 8SRS‐2Social Responsiveness Scale‐2TIVtotal intracranial volumeWCSTWisconsin Card Sorting TaskWMNworking memory network.IntroductionIt is understood that cognitive abilities change as a function of age, and many abilities decline as adults enter the middle‐age and elderly years. However, the impact of aging on the cognitive abilities of those with the developmental disorder autism spectrum disorder (ASD) is largely unknown. As the first children diagnosed with ASD are now elderly, this field of study is particularly important to the growing cohort of adults with ASD. Recent research confirmed that elderly adults with ASD, or the broader autism phenotype, report more cognitive problems than age‐matched neurotypical (NT) adults and continue to experience a low quality of life [van Heijst & Geurts, ; Wallace, Budgett, & Charlton, ]. Consequently, there is a need to further characterize cognitive and brain aging with ASD in order to inform optimal treatment and care.Aging may be particularly concerning for adults with ASD. While social communication deficits and restricted, repetitive behaviors and interest are essential, core symptoms of ASD, cognitive difficulties such

Journal

Autism Research – Wiley

Published: Jan 1, 2017

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