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Evidence for X/X chromosome translocation in humans

Evidence for X/X chromosome translocation in humans Evidence for X / X chromosome translocation in humans BY ANIL K. SINHA AND JAMES J. NORA Departments of Pediatrics, Pathology and Division of Experimental Biology Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, U . S . A . The phenotypic effects of an X/autosome translocation in mice were among the chief sources of evidence that led to the formulation of the single-active-X hypothesis (Lyon, 1961; Russell, 1961; Russell, 1963). Even though cytological examinations of such a stock of mice have shown an X-autosome insertion (Ohno & Cattanach, 1962) rather than a typical translocation, reports are available to suggest the occurrence of X/autosome translocations in humans (Mann, Valdmanis, Capps & Puite, 1965; Mukherjee & Burdette, 1966), as well as in other stocks of mice (Ohno & Lyon, 1965). Recent studies have also shown that, in the cow, the segments of an autosome may be translocated simultaneously to an X-chromosome and an autosomal member of the complement (Gustavsson, Fraccaro, Tupolo & Lindsten, 1968). The individual X-chromosomes of all these X autosome translocation bearing mammals do not suggest a random mode of differentiation in accordance with the single-active-X hypothesis. Whether or not this hypothesis is applicable to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Evidence for X/X chromosome translocation in humans

Annals of Human Genetics , Volume 33 (2) – Oct 1, 1969

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References (24)

Publisher
Wiley
Copyright
Copyright © 1969 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1969.tb01638.x
Publisher site
See Article on Publisher Site

Abstract

Evidence for X / X chromosome translocation in humans BY ANIL K. SINHA AND JAMES J. NORA Departments of Pediatrics, Pathology and Division of Experimental Biology Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, U . S . A . The phenotypic effects of an X/autosome translocation in mice were among the chief sources of evidence that led to the formulation of the single-active-X hypothesis (Lyon, 1961; Russell, 1961; Russell, 1963). Even though cytological examinations of such a stock of mice have shown an X-autosome insertion (Ohno & Cattanach, 1962) rather than a typical translocation, reports are available to suggest the occurrence of X/autosome translocations in humans (Mann, Valdmanis, Capps & Puite, 1965; Mukherjee & Burdette, 1966), as well as in other stocks of mice (Ohno & Lyon, 1965). Recent studies have also shown that, in the cow, the segments of an autosome may be translocated simultaneously to an X-chromosome and an autosomal member of the complement (Gustavsson, Fraccaro, Tupolo & Lindsten, 1968). The individual X-chromosomes of all these X autosome translocation bearing mammals do not suggest a random mode of differentiation in accordance with the single-active-X hypothesis. Whether or not this hypothesis is applicable to

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1969

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