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Robert Ross, Harold Nelson, Ira Finegold (2000)
Effectiveness of specific immunotherapy in the treatment of asthma: a meta-analysis of prospective, randomized, double-blind, placebo-controlled studies.Clinical therapeutics, 22 3
A. Custovic, A. Woodcock (2000)
Clinical effects of allergen avoidanceClinical Reviews in Allergy & Immunology, 18
M. Abramson, R. Puy, J. Weiner (1995)
Is allergen immunotherapy effective in asthma? A meta-analysis of randomized controlled trials.American journal of respiratory and critical care medicine, 151 4
Michael Abramson, R. Puy, J. Weiner (1999)
Immunotherapy in asthma: an updated systematic reviewAllergy, 54
(1998)
House dust mite control measures and the management of asthma: metaanalysis
(2001)
House dust mite control measures for asthma (Cochrane Review)
(2001)
Sensitization, asthma, and a modified Th-2 response in children exposed to cat allergen: a population based cross-sectional study
A. Nowak‐Wegrzyn (2002)
Prevention of New Sensitizations in Asthmatic Children Monosensitized to House Dust Mite by Specific Immunotherapy: A 6-Year Follow-Up StudyPediatrics
(2000)
Evidence Based Medicine, 2nd edn
Evidence‐based medicine has been defined as ‘the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. It requires the integration of clinical expertise, external evidence, and patients’ values and expectations' ( 1 ). This clearly is the ideal but what happens when evidence conflicts with the clinical experience of the allergist and, indeed, the expectation and values of the patient? This dilemma is well‐exemplified by recent systematic Cochrane‐based reviews of allergen avoidance and immunotherapy. All our readers will be aware of the widely published and, indeed, criticized Cochrane review of house dust mite control measures for asthma, published in 1998 ( 2 ). The conclusion of that review was that ‘chemical and physical methods for eradication of mites or reducing exposure to mites seemed to be ineffective and cannot be recommended as prophylactic treatment for asthma patients who are sensitive to mites’. Indeed, the paper went so far as to suggest that it was doubtful whether conducting further similar trials would be worthwhile and suggested that new avoidance measures were required. There was a fairly vocal response to this publication, with numerous letters appearing in the British Medical Journal
Pediatric Allergy and Immunology – Wiley
Published: Dec 1, 2001
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