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Evaluation of a screening test for detection of IgA antigliadin antibodies in coeliac disease

Evaluation of a screening test for detection of IgA antigliadin antibodies in coeliac disease The reliability of antigliadin antibodies of IgA and IgG classes for the diagnosis and follow‐up of coeliac disease was evaluated by ELISA tests. Forty coeliac patients, 41 patients with other gastrointestinal diseases and 50 healthy subjects were studied. IgA antigliadin antibodies were detected in all patients on unrestricted diet and in those on a challenge with a gluten‐containing diet. A low incidence of positivities was found in patients on a gluten free‐diet, while no positivity was found in controls or gastrointestinal patients. IgG determination, in contrast, showed poor specificity. Our data suggest that a positive IgA antigliadin test may be a reliable marker for the presence of active coeliac disease, which should be confirmed by intestinal biopsy; it is, moreover, a good marker for monitoring patients, since elevated values might suggest non‐compliance with the diet. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Evaluation of a screening test for detection of IgA antigliadin antibodies in coeliac disease

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References (12)

Publisher
Wiley
Copyright
Copyright © 1991 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1991.tb00186.x
Publisher site
See Article on Publisher Site

Abstract

The reliability of antigliadin antibodies of IgA and IgG classes for the diagnosis and follow‐up of coeliac disease was evaluated by ELISA tests. Forty coeliac patients, 41 patients with other gastrointestinal diseases and 50 healthy subjects were studied. IgA antigliadin antibodies were detected in all patients on unrestricted diet and in those on a challenge with a gluten‐containing diet. A low incidence of positivities was found in patients on a gluten free‐diet, while no positivity was found in controls or gastrointestinal patients. IgG determination, in contrast, showed poor specificity. Our data suggest that a positive IgA antigliadin test may be a reliable marker for the presence of active coeliac disease, which should be confirmed by intestinal biopsy; it is, moreover, a good marker for monitoring patients, since elevated values might suggest non‐compliance with the diet.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Jun 1, 1991

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