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asthma; birth cohort; children; electronic Background: Case definitions for asthma incidence in early life vary between studies medical records; epidemiology; prediction using medical records to define disease. This study assessed the impact of different approaches to using medical records on estimates of asthma incidence by age 3 and Correspondence determined the validity of early-life asthma case definitions in predicting school-age Audrey Flak Pennington, Department of asthma. Environmental Health, Rollins School of Methods: Asthma diagnoses and medications by age 3 were used to classify 7103 Public Health, Emory University, 1518 Clifton children enrolled in Kaiser Permanente Georgia according to 14 definitions of asthma. Rd NE, Mailstop 1518-002-2BB, Atlanta, GA School-age asthma was defined as an asthma diagnosis between ages 5 and 8. 30332-4201, USA Tel.: +404 712-6841 Sensitivity (probability of asthma by age 3 given school-age asthma), specificity Fax: +404 727-8744 (probability of no asthma by age 3 given no school-age asthma), positive and negative E-mail: aflak@emory.edu predictive values (probability of (no) school-age asthma given (no) asthma by age 3), and likelihood ratios (combining sensitivity and specificity) were used to determine Accepted for publication 24 April 2016 predictive ability. Results: 9.0–35.2% of children were classified as asthmatic by age 3
Pediatric Allergy and Immunology – Wiley
Published: Sep 1, 2016
Keywords: ; ; ; ; ;
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