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Ethical and practical problems of early anti‐cancer drug trials: a review of the literature

Ethical and practical problems of early anti‐cancer drug trials: a review of the literature Early clinical trials for new anti‐cancer drug treatments typically use patients with cancer as research subjects. This paper identifies some of the ethical and practical concerns that arise from the recruitment of a vulnerable group of patients and their exposure to a drug of unknown risk or benefit. This review discusses the ethical principles related to recruitment and informed consent in cancer trials, and indicates that there is a lack of consensus concerning the requirements, process and practice of informed consent. It is suggested that, as yet, little is know about patients' decision making framework in this situation, and the need for further work that concentrates on the patient's point of view is highlighted. The paper concludes by discussing some of the difficulties associated with obtaining patients’opinions, and suggests that the use of a qualitative approach may overcome some of these problems. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Cancer Care Wiley

Ethical and practical problems of early anti‐cancer drug trials: a review of the literature

European Journal of Cancer Care , Volume 5 (2) – Jun 1, 1996

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References (55)

Publisher
Wiley
Copyright
Copyright © 1996 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0961-5423
eISSN
1365-2354
DOI
10.1111/j.1365-2354.1996.tb00214.x
Publisher site
See Article on Publisher Site

Abstract

Early clinical trials for new anti‐cancer drug treatments typically use patients with cancer as research subjects. This paper identifies some of the ethical and practical concerns that arise from the recruitment of a vulnerable group of patients and their exposure to a drug of unknown risk or benefit. This review discusses the ethical principles related to recruitment and informed consent in cancer trials, and indicates that there is a lack of consensus concerning the requirements, process and practice of informed consent. It is suggested that, as yet, little is know about patients' decision making framework in this situation, and the need for further work that concentrates on the patient's point of view is highlighted. The paper concludes by discussing some of the difficulties associated with obtaining patients’opinions, and suggests that the use of a qualitative approach may overcome some of these problems.

Journal

European Journal of Cancer CareWiley

Published: Jun 1, 1996

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