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N. Mantel (1969)
Permutational Probabilities for Opening the Jackpot, 132
C. Cannings, A. Edwards (1969)
Expected genotypic frequencies in a small sample: deviation from Hardy-Weinberg equilibrium.American journal of human genetics, 21 3
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Gene frequencies and micro-differentiation among the Makiritare Indians
Cedric Smith (1970)
A note on testing the Hardy‐Weinberg LawAnnals of Human Genetics, 33
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Site distribution of cancer deaths in husband-wife and sibling pairs.Journal of the National Cancer Institute, 27
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NOTES ON BIAS IN ESTIMATIONBiometrika, 43
Rupert Miller (1964)
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Mantel Mantel, Hankey Hankey (1971)
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An exact test for randomness of matingJ. Genet., 52
Estimation and testing of a measure of non-random mating BY NATHAN MANTEL AND C. C. LI Biometry Branch, ATational Cancer Institute, Bethesda, Haryland 20014 and Department of Biostatistics, Graduate &hod of Public Heulth, University of Pittsburgh,, Pittsburgh, Pennsylvania 1526 1 The Hardy-Weinberg Law expresses the relationship between the expected relative frequencies of genotypes in a population subject to random mating. Let the relative frequencies of the three genotypes GG, Gg, and gg be D , H , and R, D + H + R = 1, so that the frequencies of the alleles G and g are p = D + aH and q = R + 3H respectively. Under random mating D = p 2 , H = 2pq, R = q2 so that D R - $ H 2 = 8 = 0. (1) Where 8 differs from zero non-random mating is occurring and, more generally, we have D = p 2 + 8 , H = 2 ( p q - 8 ) , R = p2+8. Testing whether data are consistent withâ 8 = 0 and estimating 8 and its sampling variance have received attention by various authors. Haldane (1954)provided an ingenious exact test
Annals of Human Genetics – Wiley
Published: May 1, 1974
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