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Summary Many studies on diseases associated with the major histocompatibility system rest on the hypothesis of a genetic susceptibility locus closely linked with the HLA complex in linkage disequilibrium. An alternative model is proposed which assumes an epistasis effect between the disease gene and the HLA system. Such a model is shown to give familial distribution which may simulate genetic linkage in a sample. The results are illustrated using data on insulin dependent diabetes.
Annals of Human Genetics – Wiley
Published: Oct 1, 1980
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