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Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated diseases

Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated... Summary Many studies on diseases associated with the major histocompatibility system rest on the hypothesis of a genetic susceptibility locus closely linked with the HLA complex in linkage disequilibrium. An alternative model is proposed which assumes an epistasis effect between the disease gene and the HLA system. Such a model is shown to give familial distribution which may simulate genetic linkage in a sample. The results are illustrated using data on insulin dependent diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated diseases

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References (15)

Publisher
Wiley
Copyright
Copyright © 1980 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1980.tb00958.x
Publisher site
See Article on Publisher Site

Abstract

Summary Many studies on diseases associated with the major histocompatibility system rest on the hypothesis of a genetic susceptibility locus closely linked with the HLA complex in linkage disequilibrium. An alternative model is proposed which assumes an epistasis effect between the disease gene and the HLA system. Such a model is shown to give familial distribution which may simulate genetic linkage in a sample. The results are illustrated using data on insulin dependent diabetes.

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1980

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