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Environmental enrichment and social isolation modulate inhibitory transmission and plasticity in hippocampal area CA2

Environmental enrichment and social isolation modulate inhibitory transmission and plasticity in... Environmental factors are well‐accepted to play a complex and interdependent role with genetic factors in learning and memory. The goal of this study was to examine how environmental conditions altered synaptic plasticity in hippocampal area CA2. To do this, we housed adult mice for 3 weeks in an enriched environment (EE) consisting of a larger cage with running wheel, and regularly changed toys, tunnels and treats. We then performed whole‐cell or extracellular field recordings in hippocampal area CA2 and compared the synaptic plasticity from EE‐housed mice with slices from littermate controls housed in standard environment (SE). We found that the inhibitory transmission recruited by CA3 input stimulation in CA2 was significantly less plastic in EE conditions as compared to SE following an electrical tetanus. We demonstrate that delta‐opioid receptor (DOR) mediated plasticity is reduced in EE conditions by direct application of DOR agonist. We show that in EE conditions the overall levels of GABA transmission is reduced in CA2 cells by analyzing inhibition of ErbB4 receptor, spontaneous inhibitory currents and paired‐pulse ratio. Furthermore, we report that the effect of EE of synaptic plasticity can be rapidly reversed by social isolation. These results demonstrate how the neurons in hippocampal area CA2 are sensitive to environment and may lead to promising therapeutic targets. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Environmental enrichment and social isolation modulate inhibitory transmission and plasticity in hippocampal area CA2

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Publisher
Wiley
Copyright
© 2022 Wiley Periodicals LLC.
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.23478
Publisher site
See Article on Publisher Site

Abstract

Environmental factors are well‐accepted to play a complex and interdependent role with genetic factors in learning and memory. The goal of this study was to examine how environmental conditions altered synaptic plasticity in hippocampal area CA2. To do this, we housed adult mice for 3 weeks in an enriched environment (EE) consisting of a larger cage with running wheel, and regularly changed toys, tunnels and treats. We then performed whole‐cell or extracellular field recordings in hippocampal area CA2 and compared the synaptic plasticity from EE‐housed mice with slices from littermate controls housed in standard environment (SE). We found that the inhibitory transmission recruited by CA3 input stimulation in CA2 was significantly less plastic in EE conditions as compared to SE following an electrical tetanus. We demonstrate that delta‐opioid receptor (DOR) mediated plasticity is reduced in EE conditions by direct application of DOR agonist. We show that in EE conditions the overall levels of GABA transmission is reduced in CA2 cells by analyzing inhibition of ErbB4 receptor, spontaneous inhibitory currents and paired‐pulse ratio. Furthermore, we report that the effect of EE of synaptic plasticity can be rapidly reversed by social isolation. These results demonstrate how the neurons in hippocampal area CA2 are sensitive to environment and may lead to promising therapeutic targets.

Journal

HippocampusWiley

Published: Nov 14, 2022

Keywords: environmental enrichment; hippocampal area CA2; inhibitory transmission; social isolation; synaptic plasticity

References