Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Kempermann, D. Gast, G. Kronenberg, M. Yamaguchi, F. Gage (2003)
Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice, 130
S. Ramirez, Xu Liu, Pei-Ann Lin, Junghyup Suh, Michele Pignatelli, R. Redondo, T. Ryan, S. Tonegawa (2013)
Creating a False Memory in the HippocampusScience, 341
Andrea Olson, B. Eadie, C. Ernst, B. Christie (2006)
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathwaysHippocampus, 16
G. Mckhann (2006)
Hippocampal Neurogenesis is not Required for Behavioral Effects of Environmental Enrichment.Neurosurgery, 59 2
R. Barrientos, R. O’Reilly, J. Rudy (2002)
Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context explorationBehavioural Brain Research, 134
G. Kempermann, H. Kuhn, F. Gage (1997)
More hippocampal neurons in adult mice living in an enriched environmentNature, 386
C. Clelland, M. Choi, C. Romberg, G. Clemenson, A. Fragniere, P. Tyers, S. Jessberger, L. Saksida, R. Barker, F. Gage, T. Bussey (2009)
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern SeparationScience, 325
Meshi (2006)
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichmentNat Neurosci, 9
Martina Mustroph, Shih-Fong Chen, Shalin Desai, Edward Cay, E. DeYoung, J. Rhodes (2012)
Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J miceNeuroscience, 219
J. Aimone, Janet Wiles, F. Gage (2006)
Potential role for adult neurogenesis in the encoding of time in new memoriesNature Neuroscience, 9
G. Kempermann, D. Gast, F. Gage (2002)
Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichmentAnnals of Neurology, 52
M. Fanselow (1990)
Factors governing one-trial contextual conditioningAnimal Learning & Behavior, 18
T. Kobilo, Qing-Rong Liu, Kriti Gandhi, M. Mughal, Y. Shaham, H. Praag (2011)
Running is the neurogenic and neurotrophic stimulus in environmental enrichment.Learning & memory, 18 9
E. Gould, A. Beylin, P. Tanapat, Alison Reeves, T. Shors (1999)
Learning enhances adult neurogenesis in the hippocampal formationNature Neuroscience, 2
J. Aimone, Janet Wiles, F. Gage (2009)
Computational Influence of Adult Neurogenesis on Memory EncodingNeuron, 61
A. Sierra, J. Encinas, J. Deudero, J. Chancey, G. Enikolopov, Linda Overstreet-Wadiche, S. Tsirka, M. Maletić-Savatić (2010)
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis.Cell stem cell, 7 4
A. Tashiro, Hiroshi Makino, F. Gage (2007)
Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature StageThe Journal of Neuroscience, 27
Amar Sahay, D. Wilson, R. Hen (2011)
Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory BulbNeuron, 70
H. Praag, G. Kempermann, F. Gage (1999)
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrusNature Neuroscience, 2
Wei Deng, M. Mayford, F. Gage (2013)
Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in miceeLife, 2
H. Praag, B. Christie, T. Sejnowski, F. Gage (1999)
Running enhances neurogenesis, learning, and long-term potentiation in mice.Proceedings of the National Academy of Sciences of the United States of America, 96 23
Timothy Schoenfeld, E. Gould (2012)
Stress, stress hormones, and adult neurogenesisExperimental Neurology, 233
K. Fabel, S. Wolf, D. Ehninger, H. Babu, P. Leal-Galicia, G. Kempermann (2009)
Additive Effects of Physical Exercise and Environmental Enrichment on Adult Hippocampal Neurogenesis in MiceFrontiers in Neuroscience, 3
Chunmei Zhao, Wei Deng, F. Gage (2008)
Mechanisms and Functional Implications of Adult NeurogenesisCell, 132
Carmen Vivar, M. Potter, H. Praag (2013)
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis.Current topics in behavioral neurosciences, 15
David Creer, C. Romberg, L. Saksida, H. Praag, T. Bussey (2010)
Running enhances spatial pattern separation in miceProceedings of the National Academy of Sciences, 107
M. Fanselow (1986)
Conditioned Fear‐Induced Opiate Analgesia: A Competing Motivational State Theory of Stress Analgesia aAnnals of the New York Academy of Sciences, 467
ABSTRACT Adult animals continue to modify their behavior throughout life, a process that is highly influenced by past experiences. To shape behavior, specific mechanisms of neural plasticity to learn, remember, and recall information are required. One of the most robust examples of adult plasticity in the brain occurs in the dentate gyrus (DG) of the hippocampus, through the process of adult neurogenesis. Adult neurogenesis is strongly upregulated by external factors such as voluntary wheel running (RUN) and environmental enrichment (EE); however, the functional differences between these two factors remain unclear. Although both manipulations result in increased neurogenesis, RUN dramatically increases the proliferation of newborn cells and EE promotes their survival. We hypothesize that the method by which these newborn neurons are induced influences their functional role. Furthermore, we examine how EE‐induced neurons may be primed to encode and recognize features of novel environments due to their previous enrichment experience. Here, we gave mice a challenging contextual fear‐conditioning (FC) procedure to tease out the behavioral differences between RUN‐induced neurogenesis and EE‐induced neurogenesis. Despite the robust increases in neurogenesis seen in the RUN mice, we found that only EE mice were able to discriminate between similar contexts in this task, indicating that EE mice might use a different cognitive strategy when processing contextual information. Furthermore, we showed that this improvement was dependent on EE‐induced neurogenesis, suggesting a fundamental functional difference between RUN‐induced neurogenesis and EE‐induced neurogenesis. © 2014 Wiley Periodicals, Inc.
Hippocampus – Wiley
Published: Mar 1, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.