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EM investigations of surface spread synaptonemal complexes in a human male carrier of a pericentric inversion inv(13)(p12q14): the role of heterosynapsis for spermatocyte survival

EM investigations of surface spread synaptonemal complexes in a human male carrier of a... Summary EM investigations of surface spread synaptonemal complexes of pachytene spermatocytes were performed on a human male carrier of a pericentric inv(13), ascertained through his daughter with a duplication‐deficiency of the same chromosome. The inv(13) bivalent could be unambiguously identified by either its asymmetrical kinetochores or its nucleolar association or both. There was scarcity of reversed homosynapsis of the inverted segments with inversion loops, possibly related to the small size of the inversion. The majority of pachytene spermatocytes showed the inverted segment to be either asynapsed or heterosynapsed. Generally initial homosynapsis is highly efficient with high fidelity, while heterosynapsis at the secondary pachytene pairing phase may take place with any available partner remaining unsynapsed and including the differential segments of the XY. It is suggested that survival of spermatocytes to later stages of meiosis may be ensured by heterosynapsis, and the recombinant chromosome in the offspring might be the result of a U‐type exchange. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

EM investigations of surface spread synaptonemal complexes in a human male carrier of a pericentric inversion inv(13)(p12q14): the role of heterosynapsis for spermatocyte survival

Annals of Human Genetics , Volume 50 (4) – Oct 1, 1986

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References (46)

Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1986.tb01758.x
Publisher site
See Article on Publisher Site

Abstract

Summary EM investigations of surface spread synaptonemal complexes of pachytene spermatocytes were performed on a human male carrier of a pericentric inv(13), ascertained through his daughter with a duplication‐deficiency of the same chromosome. The inv(13) bivalent could be unambiguously identified by either its asymmetrical kinetochores or its nucleolar association or both. There was scarcity of reversed homosynapsis of the inverted segments with inversion loops, possibly related to the small size of the inversion. The majority of pachytene spermatocytes showed the inverted segment to be either asynapsed or heterosynapsed. Generally initial homosynapsis is highly efficient with high fidelity, while heterosynapsis at the secondary pachytene pairing phase may take place with any available partner remaining unsynapsed and including the differential segments of the XY. It is suggested that survival of spermatocytes to later stages of meiosis may be ensured by heterosynapsis, and the recombinant chromosome in the offspring might be the result of a U‐type exchange.

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1986

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