Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Efficient Iron‐Catalyzed Reductive N‐Alkylation of Aromatic Amines with Carboxylic Acid and Phenylsilane

Efficient Iron‐Catalyzed Reductive N‐Alkylation of Aromatic Amines with Carboxylic Acid and... The development of efficient catalysts for the alkylation of amines with carboxylic acids is attracting much attention. Herein, we would like to report an earth‐abundant iron‐catalyzed protocol for the N‐alkylation of anilines using carboxylic acid as alkyl source and phenylsilane as reducing agent. With Fe2(CO)9 as a catalyst, a broad range of primary and secondary anilines are successfully converted to the corresponding tertiary anilines. Furthermore, this N‐alkylation mainly goes through the amide pathway; while the aldehyde pathway can not be ruled out. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Efficient Iron‐Catalyzed Reductive N‐Alkylation of Aromatic Amines with Carboxylic Acid and Phenylsilane

Loading next page...
 
/lp/wiley/efficient-iron-catalyzed-reductive-n-alkylation-of-aromatic-amines-VAkpLkbSS5

References (46)

Publisher
Wiley
Copyright
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201800420
Publisher site
See Article on Publisher Site

Abstract

The development of efficient catalysts for the alkylation of amines with carboxylic acids is attracting much attention. Herein, we would like to report an earth‐abundant iron‐catalyzed protocol for the N‐alkylation of anilines using carboxylic acid as alkyl source and phenylsilane as reducing agent. With Fe2(CO)9 as a catalyst, a broad range of primary and secondary anilines are successfully converted to the corresponding tertiary anilines. Furthermore, this N‐alkylation mainly goes through the amide pathway; while the aldehyde pathway can not be ruled out.

Journal

Asian Journal of Organic ChemistryWiley

Published: Sep 1, 2018

Keywords: ; ; ; ;

There are no references for this article.