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Efficacy and Safety of Local Intracoronary Drug Delivery in Treatment of No‐Reflow Phenomenon: A Pilot Study

Efficacy and Safety of Local Intracoronary Drug Delivery in Treatment of No‐Reflow Phenomenon: A... © 2016, Wiley Periodicals, Inc. DOI: 10.1111/joic.12318 PERCUTANEOUS CORONARY INTERVENTION Efficacy and Safety of Local Intracoronary Drug Delivery in Treatment of No-Reflow Phenomenon: A Pilot Study TAMER ABU ARAB, M.D., RAMY RAFIK, M.SC., and ADEL EL ETRIBY, M.D. From the Department of Cardiology, Ain Shams University Hospitals, Cairo, Egypt Background: Successful reopening of epicardial coronary artery does not always mean optimal myocardial reperfusion in a sizable portion of patients, mostly because of no-reflow phenomenon. Objectives: We investigated whether local injection of adrenaline verapamil in the distal coronary bed is more effective than their intracoronary (IC) injection through the guiding catheter in the treatment of no-reflow phenomenon following percutaneous coronary intervention (PCI). Methods: A total of 40 patients with no-reflow following PCI were randomized into two groups. Group 1 received IC adrenaline verapamil through a well-cannulated guiding catheter while Group 2 received the above-mentioned drugs in the distal coronary bed through a perfusion balloon or selective microcatheter. The primary end points were the achievement of TIMI III flow with MBG II or III. Secondary end points were the occurrence of hypotension, arrhythmias, and major adverse cardiac events (MACEs) during hospital stay. Results: After drug injection, the percentage of patients achieving http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Interventional Cardiology Wiley

Efficacy and Safety of Local Intracoronary Drug Delivery in Treatment of No‐Reflow Phenomenon: A Pilot Study

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References (26)

Publisher
Wiley
Copyright
© 2016 Wiley Periodicals, Inc.
ISSN
0896-4327
eISSN
1540-8183
DOI
10.1111/joic.12318
pmid
27465353
Publisher site
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Abstract

© 2016, Wiley Periodicals, Inc. DOI: 10.1111/joic.12318 PERCUTANEOUS CORONARY INTERVENTION Efficacy and Safety of Local Intracoronary Drug Delivery in Treatment of No-Reflow Phenomenon: A Pilot Study TAMER ABU ARAB, M.D., RAMY RAFIK, M.SC., and ADEL EL ETRIBY, M.D. From the Department of Cardiology, Ain Shams University Hospitals, Cairo, Egypt Background: Successful reopening of epicardial coronary artery does not always mean optimal myocardial reperfusion in a sizable portion of patients, mostly because of no-reflow phenomenon. Objectives: We investigated whether local injection of adrenaline verapamil in the distal coronary bed is more effective than their intracoronary (IC) injection through the guiding catheter in the treatment of no-reflow phenomenon following percutaneous coronary intervention (PCI). Methods: A total of 40 patients with no-reflow following PCI were randomized into two groups. Group 1 received IC adrenaline verapamil through a well-cannulated guiding catheter while Group 2 received the above-mentioned drugs in the distal coronary bed through a perfusion balloon or selective microcatheter. The primary end points were the achievement of TIMI III flow with MBG II or III. Secondary end points were the occurrence of hypotension, arrhythmias, and major adverse cardiac events (MACEs) during hospital stay. Results: After drug injection, the percentage of patients achieving

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Journal of Interventional Cardiology – Wiley

Published: Oct 1, 2016

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