Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Woo, K. Shin, S. Park, Ki Jang, Sunghwun Kang (2013)
Effects of exercise and diet change on cognition function and synaptic plasticity in high fat diet induced obese ratsLipids in Health and Disease, 12
J. Yu, J. Zheng, X.F. Liu, Zhiwei Feng, X.P. Zhang, L.L. Cao, Z. Zhou (2016)
Exercise improved lipid metabolism and insulin sensitivity in rats fed a high-fat diet by regulating glucose transporter 4 (GLUT4) and musclin expressionBrazilian Journal of Medical and Biological Research, 49
Lauren Chaby, S. Cavigelli, A. Hirrlinger, James Lim, Kendall Warg, V. Braithwaite (2015)
Chronic Stress During Adolescence Impairs and Improves Learning and Memory in AdulthoodFrontiers in Behavioral Neuroscience, 9
M. Elias, P. Elias, L. Sullivan, P. Wolf, R. D'Agostino (2005)
Obesity, diabetes and cognitive deficit: The Framingham Heart StudyNeurobiology of Aging, 26
R. Dahl (2004)
Adolescent Brain Development: A Period of Vulnerabilities and Opportunities. Keynote AddressAnnals of the New York Academy of Sciences, 1021
Morgan Radler, M. Hale, S. Kent (2014)
Calorie restriction attenuates lipopolysaccharide (LPS)-induced microglial activation in discrete regions of the hypothalamus and the subfornical organBrain, Behavior, and Immunity, 38
R. Barrientos, Emily Higgins, J. Biedenkapp, David Sprunger, Karli Wright-Hardesty, L. Watkins, J. Rudy, S. Maier (2006)
Peripheral infection and aging interact to impair hippocampal memory consolidationNeurobiology of Aging, 27
D. Neufer, M. Bamman, D. Muoio, C. Bouchard, Dan Cooper, B. Goodpaster, F. Booth, W. Kohrt, R. Gerszten, M. Mattson, R. Hepple, W. Kraus, M. Reid, S. Bodine, J. Jakicic, J. Fleg, John Williams, Lyndon Joseph, Mary Evans, Padma Maruvada, M. Rodgers, Mary Roary, Amanda Boyce, J. Drugan, James Koenig, R. Ingraham, D. Krotoski, Mary García-Cazarín, J. McGowan, M. Laughlin (2015)
Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.Cell metabolism, 22 1
T. Saunders, J. Chaput, M. Tremblay (2014)
Sedentary behaviour as an emerging risk factor for cardiometabolic diseases in children and youth.Canadian journal of diabetes, 38 1
P. Koteja, T. Garland, J. Sax, J. Swallow, P. Carter (1999)
Behaviour of house mice artificially selected for high levels of voluntary wheel runningAnimal Behaviour, 58
Margaret Broadwater, L. Spear (2014)
Tone conditioning potentiates rather than overshadows context fear in adult animals following adolescent ethanol exposure.Developmental psychobiology, 56 5
S. Beynon, F. Walker (2012)
Microglial activation in the injured and healthy brain: What are we really talking about? Practical and theoretical issues associated with the measurement of changes in microglial morphologyNeuroscience, 225
C. Sisk, J. Zehr (2005)
Pubertal hormones organize the adolescent brain and behaviorFrontiers in Neuroendocrinology, 26
M. Kodali, V. Parihar, B. Hattiangady, Vikas Mishra, B. Shuai, A. Shetty (2015)
Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial ActivationScientific Reports, 5
A. Mouihate, M. Galic, S. Ellis, S. Spencer, S. Tsutsui, Q. Pittman (2010)
Early Life Activation of Toll-Like Receptor 4 Reprograms Neural Anti-Inflammatory PathwaysThe Journal of Neuroscience, 30
Chloé Boitard, M. Maroun, Frédéric Tantot, Amandine Cavaroc, J. Sauvant, A. Marchand, S. Layé, L. Capuron, M. Darnaudéry, N. Castanon, E. Coutureau, R. Vouimba, G. Ferreira (2015)
Juvenile Obesity Enhances Emotional Memory and Amygdala Plasticity through GlucocorticoidsThe Journal of Neuroscience, 35
A. Ennaceur, J. Delacour (1988)
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral dataBehavioural Brain Research, 31
Sarah Cohen, R. Stackman (2015)
Assessing rodent hippocampal involvement in the novel object recognition task. A reviewBehavioural Brain Research, 285
Rachel Speisman, Ashok Kumar, A. Rani, T. Foster, B. Ormerod (2013)
Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging ratsBrain, Behavior, and Immunity, 28
M. Schroeder, L. Shbiro, V. Gelber, A. Weller (2010)
Post-weaning voluntary exercise exerts long-term moderation of adiposity in males but not in females in an animal model of early-onset obesityHormones and Behavior, 57
M. Stults-Kolehmainen (2013)
The interplay between stress and physical activity in the prevention and treatment of cardiovascular diseaseFrontiers in Physiology, 4
C. McPherson, Mineyoshi Aoyama, Mineyoshi Aoyama, G. Harry (2011)
Interleukin (IL)-1 and IL-6 regulation of neural progenitor cell proliferation with hippocampal injury: Differential regulatory pathways in the subgranular zone (SGZ) of the adolescent and mature mouse brainBrain, Behavior, and Immunity, 25
S. Lockie, Z. Andrews (2013)
The hormonal signature of energy deficit: Increasing the value of food reward.Molecular metabolism, 2 4
M. Elias, M. Elias, P. Elias, L. Sullivan, P. Wolf, R. D’Agostino (2003)
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart studyInternational Journal of Obesity, 27
S. Ryan, Y. Nolan (2016)
Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?Neuroscience & Biobehavioral Reviews, 61
A. Witte, Lucia Kerti, D. Margulies, A. Flöel (2014)
Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older AdultsThe Journal of Neuroscience, 34
Margaret Broadwater, Wen Liu, F. Crews, L. Spear (2014)
Persistent Loss of Hippocampal Neurogenesis and Increased Cell Death following Adolescent, but Not Adult, Chronic Ethanol ExposureDevelopmental Neuroscience, 36
K. Livak, Thomas Schmittgen (2001)
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.Methods, 25 4
L. Spear (2000)
The adolescent brain and age-related behavioral manifestationsNeuroscience & Biobehavioral Reviews, 24
(2009)
ABS Australian Social Trends 4102 . 0
Min Lee, R. Rakwal, J. Shibato, Koshiro Inoue, Hyukki Chang, H. Soya (2014)
DNA microarray‐based analysis of voluntary resistance wheel running reveals novel transcriptome leading robust hippocampal plasticityPhysiological Reports, 2
L. Straker, Anne Smith, B. Hands, T. Olds, R. Abbott (2013)
Screen-based media use clusters are related to other activity behaviours and health indicators in adolescentsBMC Public Health, 13
Mark Smith, Elizabeth Pitts (2012)
Wheel running decreases the positive reinforcing effects of heroinPharmacological Reports, 64
Wai Wong, M. Marinelli (2016)
Adolescent‐onset of cocaine use is associated with heightened stress‐induced reinstatement of cocaine seekingAddiction Biology, 21
I. Ziko, S. Luca, T. Dinan, J. Barwood, L. Sominsky, G. Cai, R. Kenny, L. Stokes, T. Jenkins, S. Spencer (2014)
Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-termBrain, Behavior, and Immunity, 41
Margaret Broadwater, L. Spear (2013)
Age differences in fear retention and extinction in male Sprague-Dawley rats: Effects of ethanol challenge during conditioningBehavioural Brain Research, 252
H. Hosoda, K. Doi, N. Nagaya, H. Okumura, E. Nakagawa, Mitsunobu Enomoto, Fumiaki Ono, K. Kangawa (2004)
Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples.Clinical chemistry, 50 6
A. Ennaceur, Kamel Meliani (1992)
A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memoryBehavioural Brain Research, 51
L. Swanson (1984)
The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5Trends in Neurosciences, 7
Margaret Broadwater, L. Spear (2013)
Consequences of ethanol exposure on cued and contextual fear conditioning and extinction differ depending on timing of exposure during adolescence or adulthoodBehavioural Brain Research, 256
R. Barrientos, M. Frank, N. Crysdale, T. Chapman, J. Ahrendsen, H. Day, S. Campeau, L. Watkins, S. Patterson, S. Maier (2011)
Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying ProcessesThe Journal of Neuroscience, 31
M. Cournot, J. Marquié, D. Ansiau, C. Martinaud, H. Fonds, J. Ferrières, J. Ruidavets (2006)
Relation between body mass index and cognitive function in healthy middle-aged men and womenNeurology, 67
P. Sengupta (2013)
The Laboratory Rat: Relating Its Age With Human'sInternational Journal of Preventive Medicine, 4
S. Sabia, M. Kivimaki, M. Shipley, M. Marmot, A. Singh‐Manoux (2009)
Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study.The American journal of clinical nutrition, 89 2
C. Piao, B. Stoica, Junfang Wu, B. Sabirzhanov, Zaorui Zhao, R. Cabatbat, David Loane, A. Faden (2013)
Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injuryNeurobiology of Disease, 54
Michael Hopkins, R. Nitecki, David Bucci (2011)
Physical exercise during adolescence versus adulthood: differential effects on object recognition memory and brain-derived neurotrophic factor levelsNeuroscience, 194
Amy Spiegel, Angila Sewal, P. Rapp (2014)
Epigenetic contributions to cognitive aging: disentangling mindspan and lifespanLearning & Memory, 21
K. Beavers, D. Beavers, B. Nesbit, W. Ambrosius, A. Marsh, B. Nicklas, W. Rejeski (2013)
Effect of an 18 month physical activity and weight loss intervention on body composition in overweight and obese older adultsObesity (Silver Spring, Md.), 22
T. Chaston, J. Dixon, P. O’Brien (2007)
Changes in fat-free mass during significant weight loss: a systematic reviewInternational Journal of Obesity, 31
K. Dorph‐Petersen, D. Lewis (2011)
Stereological Approaches to Identifying Neuropathology in PsychosisBiological Psychiatry, 69
S. Bajpeyi, C. Tanner, C. Slentz, B. Duscha, Jennifer McCartney, R. Hickner, W. Kraus, J. Houmard (2009)
Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation.Journal of applied physiology, 106 4
A. Pereira, Daniel Huddleston, A. Brickman, A. Sosunov, R. Hen, G. McKhann, R. Sloan, F. Gage, T. Brown, S. Small (2007)
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrusProceedings of the National Academy of Sciences, 104
R. Romeo, B. McEwen (2006)
Stress and the Adolescent BrainAnnals of the New York Academy of Sciences, 1094
R. Vetreno, Margaret Broadwater, Wen Liu, L. Spear, F. Crews (2014)
Adolescent, but Not Adult, Binge Ethanol Exposure Leads to Persistent Global Reductions of Choline Acetyltransferase Expressing Neurons in BrainPLoS ONE, 9
Thomas Schmittgen, K. Livak (2008)
Analyzing real-time PCR data by the comparative CT methodNature Protocols, 3
N. Achamrah, S. Nobis, J. Breton, P. Jésus, L. Belmonte, B. Maurer, R. Legrand, C. Bole-Feysot, J. Rego, A. Goichon, J. Rego, P. Déchelotte, S. Fetissov, S. Claeyssens, M. Coëffier (2016)
Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic miceScientific Reports, 6
H. Praag, G. Kempermann, F. Gage (1999)
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrusNature Neuroscience, 2
M. Christianson, W. Shen (2013)
Osteoporosis Prevention and Management: Nonpharmacologic and Lifestyle optionsClinical Obstetrics and Gynecology, 56
S. Andersen (2003)
Trajectories of brain development: point of vulnerability or window of opportunity?Neuroscience & Biobehavioral Reviews, 27
H. Praag, B. Christie, T. Sejnowski, F. Gage (1999)
Running enhances neurogenesis, learning, and long-term potentiation in mice.Proceedings of the National Academy of Sciences of the United States of America, 96 23
A. Miller, S. Spencer (2014)
Named Series : Diet , Inflammation and the Brain Obesity and neuroinflammation : A pathway to cognitive impairment
Adolescence is a period of significant brain plasticity that can be affected by environmental factors, including the degree of physical activity. Here we hypothesized that adolescent rats would be more sensitive to the beneficial metabolic and anti‐inflammatory effects of voluntary exercise than adult rats, whose more mature brains have less capacity for plasticity. We tested this by giving adolescent and adult Wistar rats four weeks' voluntary access to running wheels. At the end of this period we assessed metabolic effects, including weight and circulating leptin and ghrelin, as well as performance in a novel object recognition test of memory and central changes in neuronal proliferation, survival, synaptic density, and inflammatory markers in hippocampus. We found exercise reduced fat mass and circulating leptin levels in both adults and adolescents but suppressed total weight gain and lean mass in adults only. Exercise stimulated neuronal proliferation in the suprapyramidal blade of the dentate gyrus in both adults and adolescents without altering the number of mature neurons during this time frame. Exercise also increased dentate microglial numbers in adolescents alone and microglial numbers in this region were inversely correlated with performance in the novel object recognition test. Together these data suggest that adolescent hippocampal microglia are more sensitive to the effects of exercise than those of adults, but this leads to no apparent improvement in recognition memory. © 2016 Wiley Periodicals, Inc.
Hippocampus – Wiley
Published: Nov 1, 2016
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.