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Effects of carbon monoxide on early dysfunction and microangiopathy following GalT‐KO porcine pulmonary xenotransplantation in cynomolgus monkeys

Effects of carbon monoxide on early dysfunction and microangiopathy following GalT‐KO porcine... AbbreviationsABGAarterial blood gas analysisCBAcytometric bead arrayCOcarbon monoxideCOHbcarboxyhemoglobinCRISPRclustered regularly interspaced short palindromic repeatsCynoscynomolgus monkeysGalT‐KOα‐1,3‐glycosyltransferase knockoutGP1bglycoprotein IbhDAFhuman decay accelerating factorHO‐1heme oxygenase‐1HPFshigh‐power fieldshTBMhuman thrombomodulinIRIischemia‐reperfusion injuryMPOmyeloperoxidasenAbnatural antibodiesNHPnon‐human primatePBMCsperipheral blood mononuclear cellspCMVporcine cytomegalovirusSEMstandard error of the meanXLTxxeno lung transplantvWFvon Willebrand FactorINTRODUCTIONLung transplant is now a generally accepted therapy for the management of various end‐stage lung diseases such as emphysema, idiopathic pulmonary fibrosis, primary pulmonary hypertension and cystic fibrosis in humans. Approximately 3900 lung transplants were performed in 2013 in centers throughout the world. However, the number of donor organs available for transplantation still remains far fewer than the number of patients with end‐stage lung disease. There were 16 301 adult patients listed for lung transplant in the United States between May 2005 and June 2013, with 11 682 (71.7%) ultimately receiving a transplant; 2350 (14.4%) patients died or were removed from the waiting list due to becoming too sick to transplant; and 1224 (7.5%) remained on the waiting list. Therefore, interspecies transplantation, or xenotransplantation, offers the benefit of a vast supply of organs.Pigs are generally considered the best candidate for xenotransplantation donors, as they are physiologically and anatomically similar to humans. The initial development of α‐1,3‐glycosyltransferase knockout (GalT‐KO) swine substantially improved the survival of xenotransplant recipients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Effects of carbon monoxide on early dysfunction and microangiopathy following GalT‐KO porcine pulmonary xenotransplantation in cynomolgus monkeys

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References (49)

Publisher
Wiley
Copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12359
pmid
29067747
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsABGAarterial blood gas analysisCBAcytometric bead arrayCOcarbon monoxideCOHbcarboxyhemoglobinCRISPRclustered regularly interspaced short palindromic repeatsCynoscynomolgus monkeysGalT‐KOα‐1,3‐glycosyltransferase knockoutGP1bglycoprotein IbhDAFhuman decay accelerating factorHO‐1heme oxygenase‐1HPFshigh‐power fieldshTBMhuman thrombomodulinIRIischemia‐reperfusion injuryMPOmyeloperoxidasenAbnatural antibodiesNHPnon‐human primatePBMCsperipheral blood mononuclear cellspCMVporcine cytomegalovirusSEMstandard error of the meanXLTxxeno lung transplantvWFvon Willebrand FactorINTRODUCTIONLung transplant is now a generally accepted therapy for the management of various end‐stage lung diseases such as emphysema, idiopathic pulmonary fibrosis, primary pulmonary hypertension and cystic fibrosis in humans. Approximately 3900 lung transplants were performed in 2013 in centers throughout the world. However, the number of donor organs available for transplantation still remains far fewer than the number of patients with end‐stage lung disease. There were 16 301 adult patients listed for lung transplant in the United States between May 2005 and June 2013, with 11 682 (71.7%) ultimately receiving a transplant; 2350 (14.4%) patients died or were removed from the waiting list due to becoming too sick to transplant; and 1224 (7.5%) remained on the waiting list. Therefore, interspecies transplantation, or xenotransplantation, offers the benefit of a vast supply of organs.Pigs are generally considered the best candidate for xenotransplantation donors, as they are physiologically and anatomically similar to humans. The initial development of α‐1,3‐glycosyltransferase knockout (GalT‐KO) swine substantially improved the survival of xenotransplant recipients

Journal

Xenotransplantation – Wiley

Published: Jan 1, 2018

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