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Editor's Choice

Editor's Choice Growth curves of “normal” serum total IgE levels throughout childhood: a quantile analysis in a birth cohortImmunoglobulin E (IgE) was discovered in the late 1960s and soon associated with allergies. Several studies proposed different thresholds of total IgE (t‐IgE) concentration in the serum to discriminate normal from pathologic levels. However, the use of t‐IgE as a diagnostic tool for allergic diseases was soon abandoned because the frequency distribution slopes of t‐IgE levels among normal or allergic subjects overlap widely. A previous study in the “Multicentre Allergy Study” (MAS), suggested that a longitudinal pattern study of t‐IgE levels may provide more useful information than one determination at a single time point. The MAS birth cohort scheduled several peripheral blood drawings up to age 20 years, providing us with a unique opportunity to investigate serum IgE responses in childhood and adolescence.In their study based on the MAS birth cohort database, Sacco C., Perna S. et al. modeled quantile growth curves of serum total IgE levels in children never developing specific IgE against common airborne and foodborne allergen extracts from birth until age 20 years. A novel and simple chart of “normal” values has been elaborated as a tool to monitor t‐IgE levels. This chart may http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Editor's Choice

Pediatric Allergy and Immunology , Volume 28 (6) – Sep 1, 2017
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References (3)

Publisher
Wiley
Copyright
Copyright © 2017 John Wiley & Sons A/S
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.12763
Publisher site
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Abstract

Growth curves of “normal” serum total IgE levels throughout childhood: a quantile analysis in a birth cohortImmunoglobulin E (IgE) was discovered in the late 1960s and soon associated with allergies. Several studies proposed different thresholds of total IgE (t‐IgE) concentration in the serum to discriminate normal from pathologic levels. However, the use of t‐IgE as a diagnostic tool for allergic diseases was soon abandoned because the frequency distribution slopes of t‐IgE levels among normal or allergic subjects overlap widely. A previous study in the “Multicentre Allergy Study” (MAS), suggested that a longitudinal pattern study of t‐IgE levels may provide more useful information than one determination at a single time point. The MAS birth cohort scheduled several peripheral blood drawings up to age 20 years, providing us with a unique opportunity to investigate serum IgE responses in childhood and adolescence.In their study based on the MAS birth cohort database, Sacco C., Perna S. et al. modeled quantile growth curves of serum total IgE levels in children never developing specific IgE against common airborne and foodborne allergen extracts from birth until age 20 years. A novel and simple chart of “normal” values has been elaborated as a tool to monitor t‐IgE levels. This chart may

Journal

Pediatric Allergy and Immunology – Wiley

Published: Sep 1, 2017

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