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ISSN 0905-6157 Early sensitisation to food antigens â when and how? ¨ Ë Strannegard O. Early sensitisation to food antigens â when and how?. Pediatr Allergy Immunol 2001: 12(suppl 14): 20â23. # Munksgaard 2001. ¨ Ë Orjan Strannegard ¨ Department of Clinical Virology, Goteborg University, Sweden Key words: sensitisation; food allergen; Th1; Th2; DTH; IgE; IgA; IgG; IL-4; IL-12; IFN-gamma; LPS ¨ Ë Orjan Strannegard, Department of Clinical Virology, Sahlgrenska Hospital, Guldhedsgatan ¨ 10B, SE-413 46 Goteborg, Sweden Introduction Generally, the normal immunological response to orally introduced food antigens involves induction of tolerance, leading to unresponsiveness upon further exposure to the antigen. Thus, allergic sensitisation to a food antigen may be regarded as a failure of immunological tolerance. The mechanisms underlying allergic sensitisation to food allergens would then be supposed to be intimately related to those of tolerance induction. Development of tolerance can be readily demonstrated following antigen feeding in animal experiments. In humans the existence of oral tolerance was ï¬rst demonstrated in 1994, when it was shown that feeding with keyhole limpet haemocyanin induced T cell but not B cell tolerance (1. . ) Mechanisms of tolerance and sensitisation According to current concepts immunological tolerance may be
Pediatric Allergy and Immunology – Wiley
Published: May 1, 2001
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