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Early postnatal stress alters the 5‐HTergic modulation to emotional stress at postadolescent periods of rats

Early postnatal stress alters the 5‐HTergic modulation to emotional stress at postadolescent... Several lines of evidence have shown that traumatic events during the early postnatal stage might precipitate long‐lasting alteration in the functional properties underlying emotional expression. The aim of the present study was to examine whether the early postnatal stress alters the 5‐HTergic mechanism underlying regulation of emotional stress, focusing on the 5‐HT1A receptor‐mediated synaptic responses in adult rats. Pups were exposed to aversive stimulus, footshock (FS) at the postnatal period of the second (2W) and the third week (3W). At postadolescent period (10–12‐week‐old), electrophysiological and behavioral studies were performed. The 5‐HT1A receptor agonist tandospirone (10 mg/kg body wt, i.p.) blocked the long‐term potentiation (LTP) in the hippocampal CA1 field of 3W‐FS, as well as non‐FS control, whereas this inhibition was not observed in 2W‐FS group. Fear‐related freezing behavior observed during exposure to contextual fear conditioning markedly attenuated in 2W‐FS, but not in 3W‐FS. These data suggest that aversive stress exposed at 2W is attributable to changes in the 5‐HT1A receptor‐mediated synaptic plasticity, which may be responsible for the attenuation of freezing behavior. Thus, 5‐HT1A receptors appear to play a key role in the 5‐HTergic mechanism underlying regulation of emotional stress on the postnatal development of the brain. In other words, the second postnatal week may be the “critical period” for establishing proper behavioral responses to emotional stress in adult rats. © 2005 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Early postnatal stress alters the 5‐HTergic modulation to emotional stress at postadolescent periods of rats

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References (40)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.20100
pmid
15999341
Publisher site
See Article on Publisher Site

Abstract

Several lines of evidence have shown that traumatic events during the early postnatal stage might precipitate long‐lasting alteration in the functional properties underlying emotional expression. The aim of the present study was to examine whether the early postnatal stress alters the 5‐HTergic mechanism underlying regulation of emotional stress, focusing on the 5‐HT1A receptor‐mediated synaptic responses in adult rats. Pups were exposed to aversive stimulus, footshock (FS) at the postnatal period of the second (2W) and the third week (3W). At postadolescent period (10–12‐week‐old), electrophysiological and behavioral studies were performed. The 5‐HT1A receptor agonist tandospirone (10 mg/kg body wt, i.p.) blocked the long‐term potentiation (LTP) in the hippocampal CA1 field of 3W‐FS, as well as non‐FS control, whereas this inhibition was not observed in 2W‐FS group. Fear‐related freezing behavior observed during exposure to contextual fear conditioning markedly attenuated in 2W‐FS, but not in 3W‐FS. These data suggest that aversive stress exposed at 2W is attributable to changes in the 5‐HT1A receptor‐mediated synaptic plasticity, which may be responsible for the attenuation of freezing behavior. Thus, 5‐HT1A receptors appear to play a key role in the 5‐HTergic mechanism underlying regulation of emotional stress on the postnatal development of the brain. In other words, the second postnatal week may be the “critical period” for establishing proper behavioral responses to emotional stress in adult rats. © 2005 Wiley‐Liss, Inc.

Journal

HippocampusWiley

Published: Jan 1, 2005

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