Access the full text.
Sign up today, get DeepDyve free for 14 days.
T. Kojima, M. Matsumoto, H. Togashi, K. Tachibana, O. Kemmotsu, M. Yoshioka (2003)
Fluvoxamine suppresses the long-term potentiation in the hippocampal CA1 field of anesthetized rats: an effect mediated via 5-HT1A receptorsBrain Research, 959
S. Korte, B. Buwalda, O. Meijer, E. Kloet, B. Bohus (1995)
Socially defeated male rats display a blunted adrenocortical response to a low dose of 8-OH-DPAT.European journal of pharmacology, 272 1
M. Toth (2003)
5-HT1A receptor knockout mouse as a genetic model of anxiety.European journal of pharmacology, 463 1-3
M. Phillips, E. Szabadi, C. Bradshaw (1999)
The effects of the novel anxiolytic drug lesopitron, a full and selective 5-HT1A receptor agonist, on pupil diameter and oral temperature in man: comparison with buspironeJournal of Psychopharmacology, 13
L. Rueter, B. Jacobs (1996)
A microdialysis examination of serotonin release in the rat forebrain induced by behavioral/environmental manipulationsBrain Research, 739
S. Beck, S. Birnstiel, K. Choi, W. Pouliot (1997)
Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells.The Journal of pharmacology and experimental therapeutics, 281 1
Lin Xu, R. Anwyl, M. Rowan (1997)
Behavioural stress facilitates the induction of long-term depression in the hippocampusNature, 387
M. Matsumoto, H. Togashi, S. Ohashi, K. Tachibana, Taku Yamaguchi, M. Yoshioka (2004)
Serotonergic modulation of psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 fieldBrain Research, 1022
L. Heisler, H. Chu, T. Brennan, Jean Danao, Preetpaul Bajwa, L. Parsons, L. Tecott (1998)
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.Proceedings of the National Academy of Sciences of the United States of America, 95 25
M. Fanselow (1980)
Conditional and unconditional components of post-shock freezingThe Pavlovian Journal of Biological Science : Official Journal of the Pavlovian, 15
S. Gartside, Daniel Johnson, M. Leitch, C. Troakes, C. Ingram (2003)
Early life adversity programs changes in central 5‐HT neuronal function in adulthoodEuropean Journal of Neuroscience, 17
J. Feighner, W. Boyer (1989)
Serotonin-1A anxiolytics: an overview.Psychopathology, 22 Suppl 1
D. Vázquez, R. Eskandari, C. Zimmer, S. Levine, J. Lopez (2002)
Brain 5-HT receptor system in the stressed infant rat: implications for vulnerability to substance abusePsychoneuroendocrinology, 27
W. Drevets, E. Frank, J. Price, D. Kupfer, Phil Greer, C. Mathis (1999)
Pet imaging of serotonin 1A receptor binding in depressionBiological Psychiatry, 46
D. Paterson, R. Belliveau, F. Trachtenberg, H. Kinney (2004)
Differential development of 5‐HT receptor and the serotonin transporter binding in the human infant medullaJournal of Comparative Neurology, 472
E. Sibille, C. Pavlides, D. Benke, M. Toth (2000)
Genetic Inactivation of the Serotonin1A Receptor in Mice Results in Downregulation of Major GABAA Receptor α Subunits, Reduction of GABAA Receptor Binding, and Benzodiazepine-Resistant AnxietyThe Journal of Neuroscience, 20
J. Lopez, D. Chalmers, K. Little, S. Watson (1998)
Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of DepressionBiological Psychiatry, 43
K. Mori, H. Togashi, T. Kojima, M. Matsumoto, S. Ohashi, K. Ueno, M. Yoshioka (2001)
Different effects of anxiolytic agents, diazepam and 5-HT1A agonist tandospirone, on hippocampal long-term potentiation in vivoPharmacology Biochemistry and Behavior, 69
M. Matsumoto, H. Togashi, K. Mori, K. Ueno, S. Ohashi, T. Kojima, Mitsuhiro Yoshioka (2001)
Evidence for involvement of central 5-HT(4) receptors in cholinergic function associated with cognitive processes: behavioral, electrophysiological, and neurochemical studies.The Journal of pharmacology and experimental therapeutics, 296 3
D. Vázquez, J. Lopez, Helga Hoers, S. Watson, S. Levine (2000)
Maternal deprivation regulates serotonin 1A and 2A receptors in the infant ratBrain Research, 855
R. McAllister-Williams, I. Ferrier, A. Young (1998)
Mood and neuropsychological function in depression: the role of corticosteroids and serotoninPsychological Medicine, 28
Y. Iga, H. Arisawa, M. Ise, H. Yasuda, Y. Takeshita (1996)
Modulation of rhythmical slow activity, long-term potentiation and memory by muscarinic receptor agonists.European journal of pharmacology, 308 1
R. García (2001)
Stress, hippocampal plasticity, and spatial learningSynapse, 40
M. Yoshioka, M. Matsumoto, H. Togashi, H. Saito (1995)
Effects of conditioned fear stress on 5-HT release in the rat prefrontal cortexPharmacology Biochemistry and Behavior, 51
J. Béïque, Esther Chapin‐Penick, Ljiljana Mladenović, R. Andrade (2004)
Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortexThe Journal of Physiology, 556
C. Heim, C. Nemeroff (2001)
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studiesBiological Psychiatry, 49
R. Corradetti, N. Laaris, N. Hanoun, A. Laporte, E. Poul, M. Hamon, L. Lanfumey (1998)
Antagonist properties of (−)‐pindolol and WAY 100635 at somatodendritic and postsynaptic 5‐HT1A receptors in the rat brainBritish Journal of Pharmacology, 123
S. Modell, C. Lauer, W. Schreiber, J. Huber, J. Krieg, F. Holsboer (1998)
Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective DisordersNeuropsychopharmacology, 18
K Tada, K Kasamo, T Suzuki, Y Matsuzaki, T Kojima (2004)
Endogenous 5‐HT inhibits firing activity of hippocampal CA1 pyramidal neurons during contextual fear conditioning‐induced freezing behavior through stimulating 5‐HT1A receptors, 14
A. Shakesby, R. Anwyl, M. Rowan (2002)
Overcoming the Effects of Stress on Synaptic Plasticity in the Intact Hippocampus: Rapid Actions of Serotonergic and Antidepressant AgentsThe Journal of Neuroscience, 22
K. Tada, K. Kasamo, Tadashi Suzuki, Y. Matsuzaki, T. Kojima (2004)
Endogenous 5‐HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress‐induced freezing behavior through stimulating 5‐HT1A receptorsHippocampus, 14
A. Neumeister, E. Bain, A. Nugent, R. Carson, O. Bonne, D. Luckenbaugh, W. Eckelman, P. Herscovitch, D. Charney, W. Drevets (2004)
Reduced Serotonin Type 1A Receptor Binding in Panic DisorderThe Journal of Neuroscience, 24
Marian L, Wouter Hesen, E. Kloet (1991)
Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons, 11
A. Young, R. Dow, G. Goodwin, G. Fink (1993)
The effects of adrenalectomy and ovariectomy on the behavioural and hypothermic responses of rats to 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT)Neuropharmacology, 32
C. Gross, X. Zhuang, K. Stark, S. Ramboz, R. Oosting, L. Kirby, L. Santarelli, S. Beck, R. Hen (2002)
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adultNature, 416
(1996)
A microdialyaia examination of serotonin
M. Roche, K. Commons, A. Peoples, R. Valentino (2003)
Circuitry Underlying Regulation of the Serotonergic System by Swim StressThe Journal of Neuroscience, 23
J. Béïque, B. Campbell, Paul Perring, M. Hamblin, P. Walker, Ljiljana Mladenović, R. Andrade (2004)
Serotonergic Regulation of Membrane Potential in Developing Rat Prefrontal Cortex: Coordinated Expression of 5-Hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7 ReceptorsThe Journal of Neuroscience, 24
A. Papaioannou, Urania Dafni, F. Alikaridis, S. Bolaris, F. Stylianopoulou (2002)
Effects of neonatal handling on basal and stress-induced monoamine levels in the male and female rat brainNeuroscience, 114
S. Clapcote, T. Lipina, J. Millar, Shaun Mackie, S. Christie, Fumiaki Ogawa, J. Lerch, Y. Sakuraba, T. Shiroishi, J. Sled, Y. Gondo, D. Porteous, J. Roder (1998)
Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.Proceedings of the National Academy of Sciences of the United States of America, 95 24
Several lines of evidence have shown that traumatic events during the early postnatal stage might precipitate long‐lasting alteration in the functional properties underlying emotional expression. The aim of the present study was to examine whether the early postnatal stress alters the 5‐HTergic mechanism underlying regulation of emotional stress, focusing on the 5‐HT1A receptor‐mediated synaptic responses in adult rats. Pups were exposed to aversive stimulus, footshock (FS) at the postnatal period of the second (2W) and the third week (3W). At postadolescent period (10–12‐week‐old), electrophysiological and behavioral studies were performed. The 5‐HT1A receptor agonist tandospirone (10 mg/kg body wt, i.p.) blocked the long‐term potentiation (LTP) in the hippocampal CA1 field of 3W‐FS, as well as non‐FS control, whereas this inhibition was not observed in 2W‐FS group. Fear‐related freezing behavior observed during exposure to contextual fear conditioning markedly attenuated in 2W‐FS, but not in 3W‐FS. These data suggest that aversive stress exposed at 2W is attributable to changes in the 5‐HT1A receptor‐mediated synaptic plasticity, which may be responsible for the attenuation of freezing behavior. Thus, 5‐HT1A receptors appear to play a key role in the 5‐HTergic mechanism underlying regulation of emotional stress on the postnatal development of the brain. In other words, the second postnatal week may be the “critical period” for establishing proper behavioral responses to emotional stress in adult rats. © 2005 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Jan 1, 2005
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.