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Early‐life origin and prevention of chronic obstructive pulmonary diseases

Early‐life origin and prevention of chronic obstructive pulmonary diseases Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) have their roots in the womb. Together with a genetic predisposition, prenatal and early‐life factors, including maternal smoking, prematurity, and bronchopulmonary dysplasia (BPD), have a pivotal role in later respiratory health. Then, inappropriate responses to respiratory viruses (especially respiratory syncytial virus and rhinovirus) and early allergic sensitization are the strongest contributors to the inception of wheezing and early‐onset asthma. There is an urgent need for early disease biomarkers to identify profiles at higher risk of chronic respiratory conditions. Applying the “‐omic” technologies to urine, blood and breath condensate, and non‐invasive inflammometry seem promising in this regard. The description of specific risk profiles may be the key to the use of targeted personalized therapies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Early‐life origin and prevention of chronic obstructive pulmonary diseases

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References (19)

Publisher
Wiley
Copyright
Copyright © 2020 John Wiley & Sons A/S
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.13157
Publisher site
See Article on Publisher Site

Abstract

Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) have their roots in the womb. Together with a genetic predisposition, prenatal and early‐life factors, including maternal smoking, prematurity, and bronchopulmonary dysplasia (BPD), have a pivotal role in later respiratory health. Then, inappropriate responses to respiratory viruses (especially respiratory syncytial virus and rhinovirus) and early allergic sensitization are the strongest contributors to the inception of wheezing and early‐onset asthma. There is an urgent need for early disease biomarkers to identify profiles at higher risk of chronic respiratory conditions. Applying the “‐omic” technologies to urine, blood and breath condensate, and non‐invasive inflammometry seem promising in this regard. The description of specific risk profiles may be the key to the use of targeted personalized therapies.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Feb 1, 2020

Keywords: ; ;

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