Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Xu, C. Luo, JS Richardson, XM Li (2004)
Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxineThe Pharmacogenomics Journal, 4
T. Palmer, Andrew Willhoite, F. Gage (2000)
Vascular niche for adult hippocampal neurogenesisJournal of Comparative Neurology, 425
S. Hsu, L. Raine, H. Fanger (1981)
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 29
H. Scharfman, J. Goodman, Ad Macleod, Sudarshan Phani, Cara Antonelli, S. Croll (2005)
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult ratsExperimental Neurology, 192
E. Gascon, L. Vutskits, Huanxiang Zhang, M. Barral‐Moran, P. Kiss, Christophe Mas, J. Kiss (2005)
Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone‐derived neuronal progenitors in vitroEuropean Journal of Neuroscience, 21
B. Genç, E. Ulupınar, R. Erzurumlu (2005)
Differential Trk expression in explant and dissociated trigeminal ganglion cell cultures.Journal of neurobiology, 64 2
M. Yamaguchi, H. Saito, M. Suzuki, K. Mori (2000)
Visualization of neurogenesis in the central nervous system using nestin promoter‐GFP transgenic miceNeuroReport, 11
Mikko Sairanen, G. Lucas, P. Ernfors, M. Castrén, E. Castrén (2005)
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate GyrusThe Journal of Neuroscience, 25
T. Tervonen, F. Ajamian, Joris Wit, J. Verhaagen, E. Castrén, M. Castrén (2006)
Overexpression of a truncated TrkB isoform increases the proliferation of neural progenitorsEuropean Journal of Neuroscience, 24
Jason Brown, S. Couillard-Després, C. Cooper-Kuhn, J. Winkler, L. Aigner, H. Kuhn (2003)
Transient expression of doublecortin during adult neurogenesisJournal of Comparative Neurology, 467
A. Giuliani, G. D’Intino, M. Paradisi, L. Giardino, L. Calzà (2004)
p75NTR-Immunoreactivity in the subventricular zone of adult male rats: Expression by cycling cellsJournal of Molecular Histology, 35
D. Lagace, J. Yee, C. Bolaños, A. Eisch (2006)
Juvenile Administration of Methylphenidate Attenuates Adult Hippocampal NeurogenesisBiological Psychiatry, 60
Sten Linnarsson, Christopher Willson, Patrik Ernfors (2000)
Cell death in regenerating populations of neurons in BDNF mutant mice.Brain research. Molecular brain research, 75 1
R. Mullen, C. Buck, Alan Smith (1992)
NeuN, a neuronal specific nuclear protein in vertebrates.Development, 116 1
N. Hastings, E. Gould (1999)
Rapid extension of axons into the CA3 region by adult‐generated granule cellsJournal of Comparative Neurology, 413
A. Eisch, M. Barrot, C. Schad, D. Self, Eric Nestler (2000)
Opiates inhibit neurogenesis in the adult rat hippocampus.Proceedings of the National Academy of Sciences of the United States of America, 97 13
R. Duman, L. Monteggia (2006)
A Neurotrophic Model for Stress-Related Mood DisordersBiological Psychiatry, 59
C. Mandyam, Rebekah Norris, A. Eisch (2004)
Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zoneJournal of Neuroscience Research, 76
M. Lachyankar, P. Condon, P. Quesenberry, N. Litofsky, L. Recht, A. Ross (1997)
Embryonic Precursor Cells That Express Trk Receptors: Induction of Different Cell Fates by NGF, BDNF, NT-3, and CNTFExperimental Neurology, 144
Daniel Lowensteinl, Lynn Arsenaultl (1996)
The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons, 16
G. Kronenberg, K. Reuter, B. Steiner, M. Brandt, S. Jessberger, M. Yamaguchi, G. Kempermann (2003)
Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuliJournal of Comparative Neurology, 467
Jaewon Lee, W. Duan, M. Mattson (2002)
Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult miceJournal of Neurochemistry, 82
M. Donovan, Umar Yazdani, Rebekah Norris, D. Games, D. German, A. Eisch (2006)
Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's diseaseJournal of Comparative Neurology, 495
A. Russo-Neustadt, H. Alejandre, C. Garcia, Autumn Ivy, Michael Chen (2004)
Hippocampal Brain-Derived Neurotrophic Factor Expression Following Treatment with Reboxetine, Citalopram, and Physical ExerciseNeuropsychopharmacology, 29
(1999)
Analyzing data with GraphPad Prism
Q. Yan, M. Radeke, C. Matheson, J. Talvenheimo, A. Welcher, Stuart Felnstein (1997)
Immunocytochemical localization of TrkB in the central nervous system of the adult ratJournal of Comparative Neurology, 378
C. Drake, T. Milner, S. Patterson (1999)
Ultrastructural Localization of Full-Length trkB Immunoreactivity in Rat Hippocampus Suggests Multiple Roles in Modulating Activity-Dependent Synaptic PlasticityThe Journal of Neuroscience, 19
Dennis Rickman, C. Rickman (1996)
Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina.Proceedings of the National Academy of Sciences of the United States of America, 93 22
Scale bar in (a) =100μm. Scale bar in (c) =10μm and applies to b-c (except orthogonal)
G. Kempermann, S. Jessberger, B. Steiner, G. Kronenberg (2004)
Milestones of neuronal development in the adult hippocampusTrends in Neurosciences, 27
Brain‐derived neurotrophic factor (BDNF) is implicated in the regulation of adult hippocampal neurogenesis, presumably via its primary receptor, TrkB. However, controversy exists about how BDNF affects neurogenesis (e.g., proliferation vs. survival/differentiation). This controversy arises, in part, due to the lack of information about whether and when TrkB is expressed on adult neural precursors in vivo. We utilized multiple methods to analyze proliferating and maturing cells in the adult mouse subgranular zone (SGZ) for TrkB protein. Using bromodeoxyuridine (BrdU) to “birthdate” cells, we found that the proportion of proliferating cells that were TrkB‐immunoreactive (IR) was low and remained low for at least 1 week, but increased with further survival after BrdU labeling. Use of the nestin‐GFP transgenic mouse and the immature neuron marker, doublecortin (Dcx), revealed that the likelihood of being TrkB‐IR increased with presumed maturity of the cell type. Stem‐like cells, which rarely divide, were likely to express TrkB protein. However, early progenitors (GFP+/Dcx−) and late progenitors (GFP+/Dcx+), both of which are still in the cell cycle, were unlikely to be TrkB‐IR. Immature neuroblasts (GFP−/Dcx+) were more likely to express TrkB, especially as they presented a more mature morphology. Taken together, these findings emphasize that expression of TrkB protein is closely linked to progression toward neuronal maturity. This provides evidence that maturing, but not proliferating, cells in the adult mouse SGZ have the molecular machinery necessary to respond directly to BDNF. Furthermore, these findings lay critical groundwork for further exploration of the role of BDNF‐TrkB signaling in regulation of adult hippocampal neurogenesis. © 2008 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: May 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.