A straightforward synthesis of pyrrolo[3,4‐c]quinoline‐1,3‐diones and 2,3‐dihydro‐1H‐pyrrolo[3,4‐c]quinolin‐1‐ones has been accomplished by the cascade reaction of isatins with α‐oxoketene‐N,S‐acetals using BF3 ⋅ Et2O in DMSO/toluene at 110 °C. The reaction offers an easy access to biologically important tricyclic N‐heterocycles via C−C/C−X bond formation.
Asian Journal of Organic Chemistry – Wiley
Published: Nov 1, 2021
Keywords: Pyrrolo[3,4- c ]quinoline-1,3-diones; 2,3-Dihydro-1 H -pyrrolo[3,4- c ]quinolin-1-ones; BF 3 ⋅ Et 2 O; Ketene N , S -acetals; Isatins