Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Does size matter?

Does size matter? To the Editor:In recent years, there have been important advances towards clinical application in the use of pig cells, tissues or organs for the treatment of organ failure. These include the generation of pigs with multiple genetic modifications and the introduction of new immunosuppressive regimens, both to prevent rejection, and also the development of new sensitive detection methods and elimination programs to prevent the transmission of porcine microorganisms. At present, pig islet cells can maintain insulin‐independent normoglycemia for a maximum of 950 days in diabetic monkeys, the maximum survival time for the heterotopic transplantation of pig hearts to non‐human primates has increased to 945 days and in the field of kidney transplantation, three groups have achieved greater than 6‐month survival. A maximum survival of 90 days in orthotopic heart transplantation has been achieved recently.However, it is still unclear whether the difference in the sizes of pig organs and non‐human primate organs may contribute to earlier transplant failure. This problem is obvious when one considers that an adult pig at slaughter weighs 110‐125 kg and a baboon only 10‐30 kg. Abicht et al reported an enlargement of porcine intrathoracic cardiac xenotransplants in baboon recipients. An increase in the size of kidney xenotransplants from pigs with three http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Does size matter?

Download PDF
2 pages

Loading next page...
 
/lp/wiley/does-size-matter-lt3iBIf2wq

References (17)

Publisher
Wiley
Copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12383
pmid
29359359
Publisher site
See Article on Publisher Site

Abstract

To the Editor:In recent years, there have been important advances towards clinical application in the use of pig cells, tissues or organs for the treatment of organ failure. These include the generation of pigs with multiple genetic modifications and the introduction of new immunosuppressive regimens, both to prevent rejection, and also the development of new sensitive detection methods and elimination programs to prevent the transmission of porcine microorganisms. At present, pig islet cells can maintain insulin‐independent normoglycemia for a maximum of 950 days in diabetic monkeys, the maximum survival time for the heterotopic transplantation of pig hearts to non‐human primates has increased to 945 days and in the field of kidney transplantation, three groups have achieved greater than 6‐month survival. A maximum survival of 90 days in orthotopic heart transplantation has been achieved recently.However, it is still unclear whether the difference in the sizes of pig organs and non‐human primate organs may contribute to earlier transplant failure. This problem is obvious when one considers that an adult pig at slaughter weighs 110‐125 kg and a baboon only 10‐30 kg. Abicht et al reported an enlargement of porcine intrathoracic cardiac xenotransplants in baboon recipients. An increase in the size of kidney xenotransplants from pigs with three

Journal

Xenotransplantation – Wiley

Published: Jan 1, 2018

There are no references for this article.